The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

Tao Zheng,유진호,오민희,Zhou Zhu 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.2

Atopic dermatitis (AD) is an inflammatory disease characterized by pruritic skin lesions. The pathogenesis of AD may include disrupted epidermal barrier function, immunodysregulation, and IgE-mediated sensitization to food and environmental allergens. AD is also part of a process called the atopic march, a progression from AD to allergic rhinitis and asthma. This has been supported by multiple cross-sectional and longitudinal studies and experimental data. Research on the mechanisms of AD has been centered on the adaptive immune system with an emphasis on the T-helper 1 (Th1)-Th2 paradigm. Recently, the conceptual focus has largely shifted to include a primary defect in the epithelial barrier as an initial event in AD providing a significant insight into the disease initiation and pointing to a complex secondary interplay of environmental and immunological sequelae with barrier disruption. Further understanding of AD will help the development of more effective treatment for AD and ultimately, preventative algorithms for the atopic march. In this review we highlight recent advances in our understanding of the pathogenesis of AD and the atopic march.

Exploiting corpus-related ontologies for conceptualizing document corpora

Zheng, Hai-Tao,Borchert, Charles,Kim, Hong-Gee Wiley Subscription Services, Inc., A Wiley Company 2009 JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SC Vol.60 No.11

<P>As a greater volume of information becomes increasingly available across all disciplines, many approaches, such as document clustering and information visualization, have been proposed to help users manage information easily. However, most of these methods do not directly extract key concepts and their semantic relationships from document corpora, which could help better illuminate the conceptual structures within given information. To address this issue, we propose an approach called “Clonto” to process a document corpus, identify the key concepts, and automatically generate ontologies based on these concepts for the purpose of conceptualization. For a given document corpus, Clonto applies latent semantic analysis to identify key concepts, allocates documents based on these concepts, and utilizes WordNet to automatically generate a corpus-related ontology. The documents are linked to the ontology through the key concepts. Based on two test collections, the experimental results show that Clonto is able to identify key concepts, and outperforms four other clustering algorithms. Moreover, the ontologies generated by Clonto show significant informative conceptual structures.</P>

Icariside II Promotes the Differentiation of Adipose Tissue-Derived Stem Cells to Schwann Cells to Preserve Erectile Function after Cavernous Nerve Injury

Zheng, Tao,Zhang, Tian-biao,Wang, Chao-liang,Zhang, Wei-xing,Jia, Dong-hui,Yang, Fan,Sun, Yang-yang,Ding, Xiao-ju,Wang, Rui Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.6

Icariside II (ICA II) is used in erectile dysfunction treatment. Adipose tissue-derived stem cells (ADSCs) are efficient at improving erectile function. This study aimed to explore the action mechanism of ADSCs in improving erectile function. ADSCs were isolated from the adipose tissues of rats. Cell proliferation was determined using the Cell Counting Kit-8 (CCK-8) assay. The expressions of mRNA and protein were determined separately through qRT-PCR and western blot. The endogenous expressions of related genes were regulated using recombinant plasmids and cell transfection. A Dual-Luciferase Reporter Assay was performed to determine the interaction between miR-34a and STAT3. Rat models with bilateral cavernous nerve injuries (BCNIs) were used to assess erectile function through the detection of mean arterial pressure (MAP) and intracavernosal pressure (ICP). ICA II promoted ADSCs' proliferation and differentiation to Schwann cells (SCs) through the inhibition of miR-34a. Suppressed miR-34a promoted the differentiation of ADSCs to SCs by upregulating STAT3. ICA II promoted the differentiation of ADSCs to SCs through the miR-34a/STAT3 pathway. The combination of ICA II and ADSCs preserved the erectile function of the BCNI model rats. ADSCs treated with ICA II markedly preserved the erectile function of the BCNI model rats, which was reversed through miR-34a overexpression. ICA II promotes the differentiation of ADSCs to SCs through the miR34a/STAT3 pathway, contributing to erectile function preservation after the occurrence of a cavernous nerve injury.

Icariside II Promotes the Differentiation of Adipose Tissue-Derived Stem Cells to Schwann Cells to Preserve Erectile Function after Cavernous Nerve Injury

Tao Zheng,Tian-biao Zhang,Chao-liang Wang,Wei-xing Zhang,Dong-hui Jia,Fan Yang,Yang-yang Sun,Xiao-ju Ding,Rui Wang 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.6

Icariside II (ICA II) is used in erectile dysfunction treatment. Adipose tissue-derived stem cells (ADSCs) are efficient at improving erectile function. This study aimed to explore the action mechanism of ADSCs in improving erectile function. ADSCs were isolated from the adipose tissues of rats. Cell proliferation was determined using the Cell Counting Kit-8 (CCK-8) assay. The expressions of mRNA and protein were determined separately through qRT-PCR and western blot. The endogenous expressions of related genes were regulated using recombinant plasmids and cell transfection. A Dual-Luciferase Reporter Assay was performed to determine the interaction between miR-34a and STAT3. Rat models with bilateral cavernous nerve injuries (BCNIs) were used to assess erectile function through the detection of mean arterial pressure (MAP) and intracavernosal pressure (ICP). ICA II promoted ADSCs’ proliferation and differentiation to Schwann cells (SCs) through the inhibition of miR-34a. Suppressed miR-34a promoted the differentiation of ADSCs to SCs by up-regulating STAT3. ICA II promoted the differentiation of ADSCs to SCs through the miR-34a/STAT3 pathway. The combination of ICA II and ADSCs preserved the erectile function of the BCNI model rats. ADSCs treated with ICA II markedly preserved the erectile function of the BCNI model rats, which was reversed through miR-34a overexpression. ICA II pro-motes the differentiation of ADSCs to SCs through the miR-34a/STAT3 pathway, contributing to erectile function preservation after the occurrence of a cavernous nerve injury.

Research on Torque Ripple Suppression of Position Sensorless Brushless DC Motor during Commutation

Yang Tao,Li Quan-feng,Wang Shi-tao,Lu Zheng-yu 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

Position sensorless PM brushless DC motor generates pilsating current in the course of nature commutation, which causes torque ripple. In order to reduce the torque ripple, the current during commutation is controlled by certain methods which need current sensors usually. This paper proposed a novel and low cost method which can reduce torque ripple by changing the duty cycle during comutation. Experimental results show that this method is easily used to reduce the pulsating current and torque ripple during comutation without current sensors.

LLC 공진형 컨버터를 사용한 다용도 Nd:YAG 레이저 전원장치 설계

정도(Tao Zheng),김희제(Hee-Je Kim),이재철(Jae-cheol Lee),허국성(Guo-Cheng Xu) 대한전기학회 2015 전기학회논문지 Vol.64 No.6

LLC resonant converter has been widely used because of its high efficiency and high energy density. In this paper, we designed a LLC resonant converter as the main power supply of the Nd:YAG pulse laser. First harmonic approximation (FHA) is used to model the LLC resonant converter. FHA equivalent circuit model and the transfer function of the LLC resonant converter is proposed. Soft start technology is also used to suppress the surge current. The laser output simulation test result is identical with the practical test, the laser energy of every pulse can reach up to 2.5J, and the pulse per second (PPS) can be adjusted from 6 to 18. The power system is verified stable and reliable by both of the simulation and experiment results.

Dual‑mode control strategy based on DC‑bus voltage for dual‑active bridge converter in marine electromagnetic transmitter system

Haijun Tao,Changshun Du,Guopeng Zhang,Zheng Zheng 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.2

The marine electromagnetic detection method is the main method for the exploration of marine oil and gas resources. At present, the controlled source circuit of the electromagnetic transmitter is a unidirectional flow of electric energy. When the emission electrodes release the stored energy, the energy cannot be fed back, resulting in an increased DC bus and switch device voltages. The stress increases and the filter capacitors and switch devices are burned, which cannot guarantee the long-term reliable operation of the underwater devices body in the deep sea. A dual-active bridge converter is presented for the controlled source circuit of the electromagnetic transmitter. First, the topology, operating principle, and soft-switching constraints are introduced in detail. Then, a dual-mode control strategy is designed. The inductor current stress optimization control is adopted to ensure a steady-state operation, and the univariate extended phase-shifting sliding mode control is applied to achieve fast energy feedback of the inductive load. Simulation and experimental results show that the proposed circuit significantly reduces the bus voltage effect and switch device voltage stress, improves the efficiency and dynamic performance of the system, and satisfies the needs of deep-sea oil and gas resource exploration.

슈퍼 커패시터 및 태양전지를 이용한 로봇청소기용 양방향 충전시스템 설계

정도(Tao Zheng),박성욱(Sheng-Xu Piao),권대환(Dae-Hwan Kwon),구위경(Wei-Jing Qiu),김희제(Hee-Je Kim) 대한전기학회 2016 전기학회논문지 Vol.65 No.1

In this paper, a bidirectional power supply charger is proposed. This system used a solar cell panel to generate electricity and used super capacitors to store these energies, which can be used for the robot cleaner or some other electronic products. This system include a phase-shift controlled bidirectional dual active bridge (DAB) converter, solar panel super capacitors and DSP controller. In the daytime it can charge to the super capacitors to store the energy generated by the solar cell panel and in the night it will release the energy stored in the super capacitors to loads. A prototype of the proposed bidirectional power supply charger system was designed which can achieve 18V to 30V input, 10V/20W output to super capacitors and 9V/6.5W output when it acts as a charger for the robot cleaner. The system is verified to be sTable and reliable by both the simulation and experimental results.

Characterization of a novel variant HMW‐glutenin gene from Elymus canadensis

Qian‐Tao Jiang,Yu‐Ming Wei,Tao Liu,Ji‐Rui Wang,Zhi‐En Pu,Xiu‐Jin Lan,You‐Liang Zheng,Zhen‐Xiang Lu 한국유전학회 2010 Genes & Genomics Vol.32 No.4

High molecular weight (HMW) glutenin subunits (GS) play a key role in the determination of end‐use quality of wheat and other cereal crops. In this study, we report the isolation and characterization of both promoter region and ORF of novel HMW‐GS allele 1St1.3 from a perennial Triticeae species,Elymus canadensis. The amino acid (AA) sequences of E. canadensis 1St1.3 were deduced as 434 aa. Its protein primary structure comprises a signal peptide with a conserved N‐terminal domain, a central repetitive domain and a C‐terminal domain. E. canadensis 1St 1.3 possesses several distinct characteristics which are different from those of wheat HMW‐GSs. The N‐terminal domains of E. canadensis 1St 1.3 resemble that of y‐type subunits, while their C‐terminal domains are more similar to x‐type subunits. The deletion of 85 bp fragment has been observed in promoter region of 1St 1.3, however which has not interrupted the expression of this gene. Our results indicate that 1St 1.3 is novel HMW‐GS variants which will be valuable for enhancing our understanding of structural differentiation and the evolutionary relationship among HMW‐GSs in Triticeae species.

Acetylcholinesterase Inhibitive Activity-Guided Isolation of Two New Alkaloids from Seeds of Peganum Nigellastrum Bunge by an In Vitro TLC- Bioautographic Assay

Xi-yuan Zheng,Chang-hong Wang,Zi-jia Zhang,Gui-xin Chou,Tao Wu,Xue-mei Cheng,Zheng-tao Wang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9

Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to show significant inhibitory activity of acetylcholinesterase enzyme (AChE) using an in vitro TLC-bioautographic assay. In further studies to seed of P. nigellastrum Bunge, activity-guided fractionation led to the isolation of two new alkaloids nigellastrine Ⅰ (9) and nigellastrine Ⅱ (10), and along with eight known alkaloids, vasicinone (1), vasicine (2), harmine (3), deoxyvasicinone (4), deoxyvasicine (5), harmaline (6), harmol (7), harman (8), in which harmol and harman were first isolated from species P. nigellastrum Bunge. As active constituents, all compounds showed good inhibitory activities against AChE. The results of in vitro semi-quality TLC-bioautographic assay showed that harmine, harmaline and harmol displayed a similar AChE inhibitive activities comparing to galanthamine. These results indicated that these alkaloids in P. nigellastrum Bunge could be a potent class of AChEIs.