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Hu, Zheng-Hui,Lin, Yi-Wei,Xu, Xin,Chen, Hong,Mao, Ye-Qing,Wu, Jian,Xu, Xiang-Lai,Zhu, Yi,Li, Shi-Qi,Zheng, Xiang-Yi,Xie, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma. Methods: We searched PubMed, Web of Science and Scopus between 1970 and November 2012. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Twelve epidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. In a meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overall relative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidence interval [CI] 0.89-1.21). In subgroup meta-analyses by study design, there was no significant association between tea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI 0.84-1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95, 95% CI 0.81-1.12). Conclusion: Our findings do not support the conclusion that tea consumption is related to decreased risk of renal cell carcinoma. Further prospective cohort studies are required.
Microbial CRISPRi and CRISPRa Systems for Metabolic Engineering
Yi Zheng,Tianyuan Su,Qingsheng Qi 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.4
Transcriptional regulation is essential for maintaining the natural cell metabolism of microbes and therefore important for metabolic engineering. The development of non-native transcriptional regulation tools in engineered microbes may change the gene expression and metabolic flux, and shall benefit the product titer and yield in bioprocess. CRISPR interference (CRISPRi), as an artificial transcriptor which may regulate any gene at different scales, has rapidly gained popularity for metabolic engineering strains. This article briefly describes the mechanism and development of CRISPRi, including inhibition and activation of two forms of action and several different sources of dCas9 protein. And we summarize the applications of CRISPRi in regulating the metabolic pathway, changing the physiological state of the host, and genomic screening. Finally, we analyze a few limitations of the CRISPRi system and summarize some ways to improve them.
Solubility of D(−)-p-Hydroxyphenylglycine dane salt in binary methanol+isopropanol solvent mixtures
Zheng-Ming Yi,Qun-Sheng Li,Wei-Zhong Liu,Xu-Feng Sun 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.3
The solubility of D(−)-p-Hydroxyphenylglycine Dane Salt (HPGDane Salt) in binary methanol and isopropanol solvent mixtures was measured using a laser technique with the temperature range from 283.15 K to 323.15 K and mole fraction (x2) range from 0.0000 to 1.0000. The results were correlated with a semi-empirical equation.
yi Zheng,전성곤 경희대학교(국제캠퍼스) 국제지역연구원 2016 아태연구 Vol.23 No.4
In the Japanese earthquake this argument through narrative analysis of the Parties to the disaster experience. And then how to presents what is associated with pre-disaster recovery development of the dictionary. To this end, the first chapter in history and reviewed the relevance of the narrative. Especially individuals who can not fall of experience in the flow of history and review historical revisionism methodology that mean to the excitement about memory. It was a memory for ham to the ‘process’ of representation Post-narrative voice’ the history of the problem. Indicate this is conscious of hot new and memories of past experiences in the narrative in chapter 4 cover ‘substance’ offered logic that must free ourselves from memory. It was a national standpoint, and institutional sharing of historical ‘awareness of transplant’ that is not taken into consideration in order to deploying. Is a disaster memory of awareness by ‘human tolerance’ that was made by narrative. 본 논고에서는 동일본대지진 경험자인 당사자 내러티브 분석을 통해, 재해의 경험이나 기억이 어떤 의미에서 역사화되는가에 대한 문제를 고찰한다. 이를 위해 제1장에서는 역사와 내러티브의 관련성에 대해 다루어본다. 특히 역사학의 흐름에서 빠질 수 없는 개인의 경험과 기억에 대한 역사수정주의 방법론의 등장이 갖는 의미를 검토했다. 또한 내러티브(narrative)가 ‘현재적 의미에서 과거를 재현하는 것’이라는 의미를 갖는 역사성을 살펴보았다. 제2장에서는 사실로서 존재했던 ‘동일본대지진’과 ‘동일본대지진 내러티브’가 사회적 패러다임으로 자리를 잡아가는 논리의 문제점을 검토했다. 제3장에서는 내러티브 속에서 나타나는 기억의 재현이 갖는 한계점과 가능성을 고찰했다. 즉, 기억의 재현이라는 것이 사물들에 의해 지배되는 것이 아니라, 새롭게 자아를 발견하는 것임을 제시했다. 마지막으로는 새로운 내러티브 텍스트가 발생되어 화자와 청취자의 내부에서 공동으로 발견되는 ‘상호적 자아 내부의 타자성’이라는 제3의 인식이 창출될 가능성을 고찰했다.
Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B
( Yi Zheng ),( Lin Bai Ye ),( Jing Liu ),( Wei Jing ),( Khalid A. Timani ),( Xiao Jun Yang ),( Fan Yang ),( Wei Wang ),( Bo Gao ),( Zhen Hui Wu ) 생화학분자생물학회 2005 BMB Reports Vol.38 No.2
By a cDNA array representing 2308 signal transductionrelated genes, we studied the expression profiles of HeLa cells stably transfected by Hepatitis C virus nonstructural protein 4B (HCV-NS4B). The alterations of the expression of four genes were confirmed by real-time quantitative RT PCR; and the aldo-keto reductase family 1, member Cl (AKR1C1) enzyme activity was detected in HCV-NS4B transiently transfected HeLa cells and Huh-7, a human hepatoma cell line. Of the 2,308 genes we examined, 34 were up-regulated and 56 were down-regulated. These 90 genes involved oncogenes, tumor suppressors, cell receptors, complements, adhesions, transcription and translation, cytoskeletion and cellular stress. The expression profiling suggested that multiple regulatory pathways were affected by HCV-NS4B directly or indirectly. And since these genes are related to carcinogenesis, host defense system and cell homeostatic mechanism, we can conclude that HCV-NS4B could play some important roles in the pathogenesis mechanism of HCV.
Hepatitis C Virus Non-structural Protein NS4B Can Modulate an Unfolded Protein Response
Yi Zheng,Bo Gao,Li Ye,Lingbao Kong,Wei Jing,Xiaojun Yang,Zhenghui Wu,Linbai Ye 한국미생물학회 2005 The journal of microbiology Vol.43 No.6
Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing α-mannosidase-like protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1- XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.