No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

Hu, Zheng-Hui,Lin, Yi-Wei,Xu, Xin,Chen, Hong,Mao, Ye-Qing,Wu, Jian,Xu, Xiang-Lai,Zhu, Yi,Li, Shi-Qi,Zheng, Xiang-Yi,Xie, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma. Methods: We searched PubMed, Web of Science and Scopus between 1970 and November 2012. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Twelve epidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. In a meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overall relative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidence interval [CI] 0.89-1.21). In subgroup meta-analyses by study design, there was no significant association between tea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI 0.84-1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95, 95% CI 0.81-1.12). Conclusion: Our findings do not support the conclusion that tea consumption is related to decreased risk of renal cell carcinoma. Further prospective cohort studies are required.

3D Model Retrieval Based on A Colour+Geometry Signature

Yi-Fu Zheng,Lu Lv,Yong-Jin Liu (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8

Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B

Zheng, Yi,Ye, Lin-Bai,Liu, Jing,Jing, Wei,Timani, Khalid A.,Yang, Xiao-Jun,Yang, Fan,Wang, Wei,Gao, Bo,Wu, Zhen-Hui Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.2

By a cDNA array representing 2308 signal transduction related genes, we studied the expression profiles of HeLa cells stably transfected by Hepatitis C virus nonstructural protein 4B (HCV-NS4B). The alterations of the expression of four genes were confirmed by real-time quantitative RT-PCR; and the aldo-keto reductase family 1, member C1 (AKR1C1) enzyme activity was detected in HCV-NS4B transiently transfected HeLa cells and Huh-7, a human hepatoma cell line. Of the 2,308 genes we examined, 34 were up-regulated and 56 were down-regulated. These 90 genes involved oncogenes, tumor suppressors, cell receptors, complements, adhesions, transcription and translation, cytoskeletion and cellular stress. The expression profiling suggested that multiple regulatory pathways were affected by HCV-NS4B directly or indirectly. And since these genes are related to carcinogenesis, host defense system and cell homeostatic mechanism, we can conclude that HCV-NS4B could play some important roles in the pathogenesis mechanism of HCV.

Software safety in the evolution of autonomous cars

Yi Zheng 한국자동차공학회 2014 한국자동차공학회 Workshop Vol.2014 No.10

Hepatitis C Virus Non-structural Protein NS4B Can Modulate an Unfolded Protein Response

Zheng Yi,Gao Bo,Ye Li,Kong Lingbao,Jing Wei,Yang Xiaojun,Wu Zhenghui,Ye Linbai The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.6

Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing $\alpha-mannosidase-like$ protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1-XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.

Solubility of D(−)-p-Hydroxyphenylglycine dane salt in binary methanol+isopropanol solvent mixtures

Zheng-Ming Yi,Qun-Sheng Li,Wei-Zhong Liu,Xu-Feng Sun 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.3

The solubility of D(−)-p-Hydroxyphenylglycine Dane Salt (HPGDane Salt) in binary methanol and isopropanol solvent mixtures was measured using a laser technique with the temperature range from 283.15 K to 323.15 K and mole fraction (x2) range from 0.0000 to 1.0000. The results were correlated with a semi-empirical equation.

기억 내러티브의 이중성과 역사화의 탈정치성

yi Zheng,전성곤 경희대학교(국제캠퍼스) 국제지역연구원 2016 아태연구 Vol.23 No.4

In the Japanese earthquake this argument through narrative analysis of the Parties to the disaster experience. And then how to presents what is associated with pre-disaster recovery development of the dictionary. To this end, the first chapter in history and reviewed the relevance of the narrative. Especially individuals who can not fall of experience in the flow of history and review historical revisionism methodology that mean to the excitement about memory. It was a memory for ham to the ‘process’ of representation Post-narrative voice’ the history of the problem. Indicate this is conscious of hot new and memories of past experiences in the narrative in chapter 4 cover ‘substance’ offered logic that must free ourselves from memory. It was a national standpoint, and institutional sharing of historical ‘awareness of transplant’ that is not taken into consideration in order to deploying. Is a disaster memory of awareness by ‘human tolerance’ that was made by narrative. 본 논고에서는 동일본대지진 경험자인 당사자 내러티브 분석을 통해, 재해의 경험이나 기억이 어떤 의미에서 역사화되는가에 대한 문제를 고찰한다. 이를 위해 제1장에서는 역사와 내러티브의 관련성에 대해 다루어본다. 특히 역사학의 흐름에서 빠질 수 없는 개인의 경험과 기억에 대한 역사수정주의 방법론의 등장이 갖는 의미를 검토했다. 또한 내러티브(narrative)가 ‘현재적 의미에서 과거를 재현하는 것’이라는 의미를 갖는 역사성을 살펴보았다. 제2장에서는 사실로서 존재했던 ‘동일본대지진’과 ‘동일본대지진 내러티브’가 사회적 패러다임으로 자리를 잡아가는 논리의 문제점을 검토했다. 제3장에서는 내러티브 속에서 나타나는 기억의 재현이 갖는 한계점과 가능성을 고찰했다. 즉, 기억의 재현이라는 것이 사물들에 의해 지배되는 것이 아니라, 새롭게 자아를 발견하는 것임을 제시했다. 마지막으로는 새로운 내러티브 텍스트가 발생되어 화자와 청취자의 내부에서 공동으로 발견되는 ‘상호적 자아 내부의 타자성’이라는 제3의 인식이 창출될 가능성을 고찰했다.

Hepatitis C Virus Non-structural Protein NS4B Can Modulate an Unfolded Protein Response

Yi Zheng,Bo Gao,Li Ye,Lingbao Kong,Wei Jing,Xiaojun Yang,Zhenghui Wu,Linbai Ye 한국미생물학회 2005 The journal of microbiology Vol.43 No.6

Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing α-mannosidase-like protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1- XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.

Microbial CRISPRi and CRISPRa Systems for Metabolic Engineering

Yi Zheng,Tianyuan Su,Qingsheng Qi 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.4

Transcriptional regulation is essential for maintaining the natural cell metabolism of microbes and therefore important for metabolic engineering. The development of non-native transcriptional regulation tools in engineered microbes may change the gene expression and metabolic flux, and shall benefit the product titer and yield in bioprocess. CRISPR interference (CRISPRi), as an artificial transcriptor which may regulate any gene at different scales, has rapidly gained popularity for metabolic engineering strains. This article briefly describes the mechanism and development of CRISPRi, including inhibition and activation of two forms of action and several different sources of dCas9 protein. And we summarize the applications of CRISPRi in regulating the metabolic pathway, changing the physiological state of the host, and genomic screening. Finally, we analyze a few limitations of the CRISPRi system and summarize some ways to improve them.

일본유교와 "황국(皇國) 국체" 이데올로기

( Zheng Yi ),전성곤 ( Sung Kon Jun ) 한국세계지역학회 2015 世界地域硏究論叢 Vol.33 No.2

서구와 동양을 접목시켜 새롭게 이론을 창출하는 ‘탈구축’ 이론 속에는 ‘서구와 동양의 내용 양자’를 통합하여 외부 위치로 새롭게 재구성해 내는 것이라고 보는 시각이 존재한다. 그렇지만 이 탈구축 이론은 실은 오카와 슈메이(大川周明)의 논리에서 보면 ‘반쪽 탈구축’이었다. 오카와 슈메이의 탈구축 이론 속에는 ‘제3의 입장에서’ 심급을 통해 양쪽을 무효화 시키면서 그 구조 자체를 논하기 보다는 전혀 다른 구조를 찾아내는 것으로서 나머지 반쪽 탈구축을 통해 ‘완전한 내적 공동체 논리로서 천황제’를 탈구축해 냈다. 그것은 일본의 ‘우익적사고’가 전통적 탈구축 이론과 다른 구조를 찾아내는 의미에서의 탈구축이 접목되는 특성을 가졌다는 것을 설명해 주는 것이다. 이에 대표적인 사상가가 바로 오카와 슈메이였다. 오카와 슈메이는 『대학』과 『중용』을 ‘유교사상’적 측면에서 관심을 가지면서도 종교철학적 시대적 흐름 속에서 이를 재해석해 냈다. 물론 오카와 슈메이가 사상가인가 철학자인가라는 문제라기보다는, 대학과 중용을 해독하는 방법론에서, 유교가 ‘종교, 도덕, 정치’가 공통적으로 갖고 있는 것을 ‘도(道)’라고 규정하면서 출발하는데, 그것은 종교학이나 종교사 연구에서 ‘모든 종교의 공통적 특성’을 극대화시킨 작업과 연결된다는 점이었다. 이를 통해 새롭게 학문의 지평을 여는 방식을 ‘원리’를 체현해 냈다. 오카와 슈메이는 대학에서는 ‘친민(親民)’을 ‘신민(新民)’이라고 해석하면서 수도(修道)의 ‘수(修)’를 ‘수양한다’가 아니라 ‘수양해야 하는것’으로 다르게 해석한다. 그런데 중요한 것은 개인 개인에게 모두 선험적으로 주어진 도는 수양이 중요하기 때문이었다. 그것은 바로 개인의 수양과 신민을 통한 새로운 사회 구현이 필요했기 때문이다. 이것에는 도의 수양과 성이 핵심으로 작용한다고 보았다. 이를 통해 오카와 슈메이는 유교가 서구 학자들이 주장하는 개인과 사회의 관계를 통합해주고, 유교 내부에서의 논쟁을 극복해 냈다. 그 과정에서 중(中)은, 시대적 흐름에 변화하지 않는 보편성을 가진 것으로 동시에 자아와 타자를 초월하여 존재 것을 자각하는 ‘경지’로 설명된다. 그것은 중국에서는 없어진 ‘전통과 황통이 일본의 ‘신도’ 속에 그것이 모두 포함된다고 주장했다. 그것은 바로 ‘자연적인 것=천사상과 도덕적인 것=성과 덕 그리고 평등한 것=천지인’을 통해, 황국 국체가 『대학』과 『중용』에서 찾을 수 있다는 ‘중용이데올로기’를 창출해 낸 것이었다. In the theory of “deconstruction” that creates a new theory by grafting the west and the orient, there is the point of view that ‘both sides of the west and the orient’is combined and newly restructured to “outer” location. However, this deconstruction theory was ‘half deconstruction’ in the logic of Okawa Shumei. The theory of deconstruction of Okawa Shumei did not discuss the structure itself by nullifying both sides through the instance ‘from the stance of the third party’, but found a whole new structure, deconstructing ‘the Emperor system as a ‘logic of complete internal community’ through the half deconstruction. One of the representative theorists was Okawa Shumei. He not only took an interest into “Daehak” and “Jungyong” from the aspect of ‘Confucian ideas’ but also reinterpreted the theories in a philosophy of religion and stream of times. Of course, rather than the issue that Shumei is a theorist or philosopher, the issue starts from describing the common values of ‘religion, ethics and politics’ of Confucianism as ‘morality’. This is linked to the works maximized the ‘common characteristics of all religions’ in researches on science of religion or religious history. By doing so, he materialized the ‘principle’ of how to open a new prospect in the field of the study. Okawa Shumei interpreted ‘citizens(親民)’ as ‘subjects(新民)’in Daehak and ‘ascetic(修)’ of ascetic practice(修道) as ‘have to cultivate’ rather than ‘cultivate’. Because what’s important was self-discipline of morality intuitively given to individuals. This indicated that self-discipline of morality and sincerity played a key role. By doing so, Okawa Shumei showed that Confucianism integrated the relationship between individuals and nation argued by the western scholars and overcome the disputes within Confucianism. Middle during the process has universality that does not change by the stream of times and at the same time is explained as a ‘level’ to recognize presence by transcending ego and others. It was argued that the lost ‘tradition and imperial line’ in China were all included in Japanese Shinto. In other words, based on the idea of ‘something natural = heavens thought and something moral = sincerity and virtue and something equal = heaven, land, benevolence(仁)’, the forms of the empire created ‘Jungyong ideology’ that can be found in “Daehak” and “Jungyong”.