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Song, Jong- Hwan,Kim, Sun-Gi,No, Zae-Sung,Hyun, Young-Lan,Jeon, Dong-Ju,Kim, Ik-Yon Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.8
The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.
Direct Access to Various 1-Substituted-imidazo[1,5-a]pyridine-3(2H)-thione Derivatives.
Kim, Ikyon,Lee, Ge Hyeoung,No, Zae Sung WILEY-VCH Verlag 2007 Chem Inform Vol.38 No.34
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.</P>
Son, Mee-Young,Kim, Tae-Jeong,Kweon, Kwang-In,Park, Jong-Il,Park, Chung,Lee, Young-Chul,No, Zae-Sung,Ahn, Jong-Woong,Yoon, Wan-Hee,Park, Seung-Kiel,Lim, Kyu,Hwang, Byung-Doo 충남대학교 암연구소 2003 암연구소 업적집 Vol.3 No.-
DNA topoisomerase IIα (Topo IIα) is regulated in late S phase-dependent manner. To identify late S phase-dependent cisacting elements of Topo IIα gene, we have investigated the synchronized HeLa cells with chloramphenicol acetyltransferase and DNase I footprinting assays. The level of Topo IIα mRNA increased after release from aphidicolin block and reached a maximum in 8 h (late S phase) in HeLa cells, and Topo II unknotting activity was also in parallel with the level of Topo IIα mRNA. The late S phase-regulatory element was found to be located in the region containing ATF-binding element between -290 and-90 bp and the region was required for a maximal stimulation during late S phase. DNase I footprinting assay showed that ATF-binding element and novel cis-acting element (Topo IIα-specific sequence) were the principal protein-binding sites and the proteins interacting with these elements were induced during late S phase. One DNA-protein complex was formed by DNA mobility shift assay when ATF-binding site was incubated with nuclear extract prepared from late S phase cells, but no protein bound in non-S phase cells. Taken together, these results suggest that ATF may be essential transacting factor for maximal expression of Topo IIα gene during late S phase in HeLa cells.