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Yunju Lee(Yunju Lee) J-INSTITUTE 2022 Public Value Vol.7 No.2
Purpose: The purpose of this study is to not only explore, in regards to the international students studying in Korea, the influence of external motivation for studying abroad on the academic adjustment and the educational satisfaction, but also the infrastructure services, which are currently various external motivations for the inter-national students at each university, thereby preparing the basic data needed to build the customized practical cases appropriate for the future society. Method: In this study, from November 2019 to January 2020, 450 international students enrolled at universi-ties in Daegu and Gyeongbuk were surveyed, and the cluster sampling method was used, and the survey was conducted using the self-administration method. Among the collected questionnaires, 322 questionnaires were used as a valid sample, excluding the data in which the responses were insincere or some of the contents of the survey were omitted, and a questionnaire was conducted on the external motivation, academic adjustment, and educational satisfaction among the international students. For the data processing of the study, using the SPSS 23.0, frequency analysis, Cronbach's α coefficient calculation, factor analysis, correlation analysis, and the mul-tiple regression depending on the purpose of data analysis were used. Results: As a result of the factor analysis and reliability test for external motivation in factor analysis and reliability test, the eigenvalue and reliability of the factor turned out to be 2.873(α=.832) and 2.801(α=.806), and the academic adjustment turned out to be an adjustment factor of 2.942(α=.825), educational satisfaction turned out to be a facility/administrative factor of 2.531(α=.776), and a teaching/class factor of 2.149(α=.766). Overall, it turned out that the external motivation affects the academic adjustment and the educational satisfaction. Conclusion: It is significant in that it examines the correlations between 'motivation to study abroad', 'study adaptation', and 'educational satisfaction' of the international students from the perspective of transnationalism which leads to 'study-employment-immigration'. Accordingly, in order for the international students to adapt to their studies and satisfy their education, the infrastructure services, which are motives outside of studying abroad, must be strengthened.
Kim, Yunju,Sim, Sung Hoon,Park, Boram,Lee, Keun Seok,Chae, In Hye,Park, In Hae,Kwon, Youngmi,Jung, So-Youn,Lee, Seeyoun,Ko, Kyounglan,Kang, Han-Sung,Lee, Chan Wha,Lee, Eun Sook Elsevier 2018 Clinical breast cancer Vol.18 No.6
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>To investigate the diagnostic performance of magnetic resonance imaging (MRI) for predicting pathologic complete response after neoadjuvant chemotherapy (NAC) depending on subtypes of breast cancer using different interpretation thresholds of MRI negativity.</P> <P><B>Patients and Methods</B></P> <P>A total of 353 women with breast cancer who had undergone NAC were included. Pathologic examination after complete surgical excision was the reference standard. Tumors were divided into 4 subtypes on the basis of expression of hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2). Tumor enhancement was assessed on early and late phases of MRI. MRI negativity was divided into radiologic complete response (rCR, complete absence of enhancement on both early and late phases) and near-rCR (no discernible early enhancement but observed late enhancement).</P> <P><B>Results</B></P> <P>Ninety (25.5%) of 353 patients experienced pathologic complete response. When analyzing the data of all patients, sensitivity of MRI was higher for rCR versus near-rCR (97.72% vs. 90.49%, <I>P</I> < .0001), whereas specificity was lower for rCR versus near-rCR (44.44% vs. 72.22%, <I>P</I> < .0001). Accuracy was equivalent (84.14% vs. 85.84%). In HR−HER2<SUP>+</SUP> tumors, 100% sensitivity and negative predictive value were achieved by assessing early enhancement only. In HR<SUP>+</SUP>HER2− tumors, sensitivity of MRI was higher for rCR versus near-rCR (96.12% vs. 86.82%, <I>P</I> = .0005).</P> <P><B>Conclusion</B></P> <P>Diagnostic performance of MRI after NAC differs in accordance with the subtypes and threshold of MRI negativity. MRI assessment with consideration of tumor subtypes is required, along with standardization of MRI interpretation criteria in the NAC setting.</P>
Polysulfide rejection layer from alpha-lipoic acid for high performance lithium-sulfur battery
Song, Jongchan,Noh, Hyungjun,Lee, Hongkyung,Lee, Je-Nam,Lee, Dong Jin,Lee, Yunju,Kim, Chul Hwan,Lee, Yong Min,Park, Jung-Ki,Kim, Hee-Tak The Royal Society of Chemistry 2015 Journal of Materials Chemistry A Vol.3 No.1
<P>The polysulfide shuttle has been an impediment to the development of lithium-sulfur batteries with high capacity and cycling stability. Here, we report a new strategy to remedy the problem that uses alpha-lipoic acid (ALA) as an electrolyte additive to form a polysulfide rejection layer on the cathode surface<I>via</I>the electrochemical and chemical polymerization of ALA and a stable solid electrolyte interface (SEI) layer on the Li metal anode during the first discharge. The poly(ALA) layer formed<I>in situ</I>effectively prevents the polysulfide shuttle and consequently enhances the discharge capacity and cycling stability, owing to the Donnan potential developed between the polysulfide-concentrated cathode and the fixed negative charge-concentrated poly(ALA) layer. Also, the SEI layer additionally prevents the chemical reaction of the polysulfide and Li metal anode. The approach, based on the double effect, encompasses a new scientific strategy and provides a practical methodology for high performance lithium-sulfur batteries.</P>
고성능 리튬 설퍼 전지 구현을 위한 폴리설파이드 억제막
( Hee-tak Kim ),( Jongchan Song ),( Hyungjun Noh ),( Hongkyung Lee ),( Je-nam Lee ),( Dong Jin Lee ),( Yunju Lee ),( Chul Hwan Kim ),( Yong Min Lee ),( Jung-ki Park ) 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
The polysulfide shuttle has been an impediment to the development of lithium-sulfur batteries with high capacity and cycling stability. Here, we report a new strategy to remedy the problem that uses alpha-lipoic acid (ALA), as an electrolyte additive to form a polysulfide rejection layer on the cathode surface via the electrochemical and chemical polymerization of ALA during the first discharge. The poly(ALA) layer formed in situ effectively prevents the polysulfide shuttle and consequently enhances the discharge capacity and cycling stability, owing to the Donnan potential developed between the polysulfide-concentrated cathode and the fixed negative charge-concentrated poly(ALA) layer. The approach, based on a thermodynamic equilibrium and a natural material, encompasses a new scientific strategy and provides a practical methodology for high performance lithium-sulfur batteries.
Lee, Seungmin,Lee, Youngjun,Park, Sungwon,Kim, Yunju,Lee, Ju Dong,Seo, Yongwon American Chemical Society 2012 The Journal of physical chemistry B Vol.116 No.30
<P>The precise nature and unique pattern of the double tetra-<I>n</I>-butylammonium fluoride (TBAF) semiclathrates with a guest gas (CH<SUB>4</SUB> or CO<SUB>2</SUB>) was closely investigated through thermodynamic and spectroscopic analyses. The three-phase equilibria of semiclathrate (H), liquid water (L<SUB>W</SUB>), and vapor (V) for the ternary CH<SUB>4</SUB> + TBAF + water and CO<SUB>2</SUB> + TBAF + water mixtures with various TBAF concentrations were experimentally measured in order to determine the stability conditions of the double TBAF semiclathrates. The double CH<SUB>4</SUB> (or CO<SUB>2</SUB>) + TBAF semiclathrates showed remarkably enhanced thermal stability when compared with pure CH<SUB>4</SUB> (or CO<SUB>2</SUB>) hydrate. The highest stabilization effect was observed at the stoichiometric concentration of pure TBAF semiclathrate, which is 3.3 mol %. Gas uptake measurements were undertaken in order to estimate the amount of gas consumed during double semiclathrate formation. CH<SUB>4</SUB> was found to be a relatively more favorable guest for the 5<SUP>12</SUP> cages of the double TBAF semiclathrate than CO<SUB>2</SUB>. From the results of the NMR and Raman spectroscopic analyses it was identified that the guest gas molecules (CH<SUB>4</SUB> or CO<SUB>2</SUB>) were enclathrated in the 5<SUP>12</SUP> cages of the double TBAF semiclathrates. The overall results given in this study are useful for understanding the fundamental guest gas enclathration behavior in the double semiclathrates.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpcbfk/2012/jpcbfk.2012.116.issue-30/jp302647c/production/images/medium/jp-2012-02647c_0001.gif'></P>
LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Lee Jibeom,Kim Hyeonhui,Kang Yun-Won,Kim Yumin,Park Moon-young,Song Ji-Hong,Jo Yunju,Dao Tam,Ryu Dongryeol,Lee Junguee,Oh Chang-Myung,Park Sangkyu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade, NAFLD prevalence and incidence have risen globally. There are currently no effective licensed drugs for its treatment. Thus, further study is required to identify new targets for NAFLD prevention and treatment. In this study, we fed C57BL6/J mice one of three diets, a standard chow diet, high-sucrose diet, or high-fat diet, and then characterized them. The mice fed a high-sucrose diet had more severely compacted macrovesicular and microvesicular lipid droplets than those in the other groups. Mouse liver transcriptome analysis identified lymphocyte antigen 6 family member D (Ly6d) as a key regulator of hepatic steatosis and the inflammatory response. Data from the Genotype-Tissue Expression project database showed that individuals with high liver Ly6d expression had more severe NAFLD histology than those with low liver Ly6d expression. In AML12 mouse hepatocytes, Ly6d overexpression increased lipid accumulation, while Ly6d knockdown decreased lipid accumulation. Inhibition of Ly6d ameliorated hepatic steatosis in a diet-induced NAFLD mouse model. Western blot analysis showed that Ly6d phosphorylated and activated ATP citrate lyase, which is a key enzyme in de novo lipogenesis. In addition, RNA- and ATAC-sequencing analyses revealed that Ly6d drives NAFLD progression by causing genetic and epigenetic changes. In conclusion, Ly6d is responsible for the regulation of lipid metabolism, and inhibiting Ly6d can prevent diet-induced steatosis in the liver. These findings highlight Ly6d as a novel therapeutic target for NAFLD.