전류에 관한 오개념 교정을 위한 비유수업의 효과

박윤배,박윤선 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-

The purpose of this study was to examine the effect of analogy instruction for correcting middle school students' misconceptions on electric current. A total of 23 subjects ranged from 7 to 9 grade were sampled as volunteer from an urban area middle school. Two group pretest-posttest design was used. A formative test was also administered to check the subjects' understanding about the treatment instruction. An automatic doll analogy was developed for this study. As result, the analogy instruction was effective for correcting most misconceptions on electric current, especially SF(sequential flow) idea, RI(resistance irrelevant) idea, and DP(current at direct circuit greater than at pararrel circuit) idea.

Association between exhaled volatile organic compounds and eosinophil count in chronic obstructive pulmonary disease

( Yune Young Shin ),( Ho Il Yoon ),( Choon-taek Lee ),( Jae Ho Lee ),( Young-jae Cho ),( Jong Sun Park ),( Yeon Joo Lee ),( Eun Sun Kim ),( Sung Yoon Lim ),( Byung Soo Kwon ),( Yong Hee Lee ),( Sun Yo 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Introduction: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients respond differently to treatment. Blood eosinophil count can serve as a predictive biomarker for the efficacy of inhaled corticosteroid treatment. Analysis of exhaled breath for volatile organic compounds (VOCs) also offers the possibility of noninvasive diagnosis and biomarker for underlying inflammation in various diseases. The aim of this study was to evaluate the association between exhaled VOCs and blood eosinophil count in patients with COPD. Methods: We conducted a prospective study on 108 patients with stable COPD recruited from the tertiary-care academic hospital. End-tidal exhalation breath of every enrolled patients was collected and analyzed by using gas chromatography- mass spectrometry to identify specific VOCs. All patients checked VOCs more than one time in different days to minimize bias and the difference of VOCs between room air and the exhaled gas was calculated. Results: In this prospective study, the average age was 71.7 ± 8.2 years and 97.2% (105) were male. Patients were divided into two groups based on the eosinophil count: those involving eosinophil counts of less than 300 (n=22) and those involving counts of 300 or more (n=86). Three VOCs were significantly lower in the group with high eosinophil count: Undecane (108800.7 ± 109230.2, p=0.017), Phthalicanhydride (69315.2 ± 57919.6, p=0.038) and Ethylbenzene (60378.3 ± 57227.3, p=0.032). Among these VOCs, ROC analysis for Udecane showed high sensitivity (57.1%) and specificity (88.0%) for high eosinophil count in patients with COPD. Conclusion: In this prospective cohort study, Udecane among VOCs can be used as the predictive marker for high serum eosinophil level.

High-performance field emission of carbon nanotube paste emitters fabricated using graphite nanopowder filler

Sun, Yuning,Yun, Ki Nam,Leti, Guillaume,Lee, Sang Heon,Song, Yoon-Ho,Lee, Cheol Jin IOP 2017 Nanotechnology Vol.28 No.6

<P>Carbon nanotube (CNT) paste emitters were fabricated using graphite nanopowder filler. The CNT paste emitters consist of CNTs as the emitting material, graphite nanopowder as the filler and a graphite rod as the cathode. Rather than metal or inorganic materials, graphite nanopowder was adapted as a filler material to make the CNT paste emitters. After fabricating the emitters, sandpaper treatment was applied to increase the density of emission sites. The CNT paste emitters showed a high field emission performance, for example a high emission current of 8.5 mA from a cylindrical emitter with a diameter of?0.7 mm (corresponding to a current density of 2.2 A cm<SUP>−2</SUP>) and an extremely stable emission current at 1 mA (260 mA cm<SUP>−2</SUP> for 20 h). Interestingly, after a number of electrical arcing events, the emitters still showed a high emission current of 5–8 mA (higher than 1 A cm<SUP>−2</SUP>). In addition to the sound electrical and thermal properties of the graphite filler, effective mechanical adhesion of the CNTs onto the graphite cathode induced by the use of the graphite nanopowder filler contributed the excellent field emission properties of the CNT paste emitters.</P>

Development of Ground Organic Monolith Particles as Packing Material in High Performance Liquid Chromatography

Yune Sung Kim,Jeong Soo Kim,Genlin Sun,Won Jo Cheong 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.2

Organic monolith particles and their chromatography performance.

교회와 그 헌법

박윤선(Yune Sun Park) 합동신학대학원대학교 출판부 1986 신학정론 Vol.4 No.2

우리 기독자들의 만족

박윤선(Yune Sun Park) 합동신학대학원대학교 출판부 1985 신학정론 Vol.3 No.1

Change of Clostridium difficile Colitis during Recent 10 Years in Korea

Lee, Yune Jeong,Choi, Myung Gyu,Lim, Chul Hyun,Jung, Woong Ryong,Cho, Hyun Sun,Sung, Hye Young,Nam, Kwan Woo,Chang, Jae Hyuck,Cho, Yu Kyung,Park, Jae Myung,Kim, Sang Woo,Chung, In Sik The Korean Society of Gastroenterology 2010 대한소화기학회지 Vol.55 No.3

<P>Background/Aims: Our clinical experience and recent published literatures suggest that Clostridium difficile colitis (CDC) has become more common and potentially more pathogenic in recent years. The aim of study was to evaluate changes in the epidemiological features of CDC in hospitalized patients in Korea. Methods: We retrospectively reviewed all patients of CDC diagnosed at Kangnam St. Mary Hospital from 1998 to 2007. CDC was defined as having a positive C. difficile cytotoxicity assay, or endoscopic or pathologic evidence of CDC. Results: A total of 189 cases (male 73, female 116, mean age 63.3 years) of CDC were diagnosed during the study period. The prevalence of CDC increased from 1.9/10,000 patient admissions in 1998-1999 to 8.82/10,000 patient admissions in 2006-2007. One hundred sixty three indication for cases (86.2%) of patients identified a prior use of antibiotics in the 2 months preceding diagnosis. The most common antibiotic use was prophylactic use during perioperational period (33.3%) followed by pneumonia (23.3%). The overall response rate to initial antibiotics was 82.7%. One hundred seventy two (91%) patients were initially treated with metronidazole. The response rate was 84.3%. All patients with initial failure to metronidazole were successfully treated by vancomycin. The response rate of vancomycin as first treatment was 80%. Three deaths were associated with CDC despite the use of combination of metronidazole and vancomycin. Conclusions: The prevalence of CDC in hospitalized patients in Korea significantly increased from 1998 to 2007.</P>

화평과 성결

박윤선(Yune Sun Park) 합동신학대학원대학교 출판부 1983 신학정론 Vol.1 No.2

최근 10년간 Clostridium difficile 대장염의 임상 양상 변화

이윤정 ( Yune Jeong Lee ),최명규 ( Myung Gyu Choi ),임철현 ( Chul Hyun Lim ),정웅룡 ( Woong Ryong Jung ),조현선 ( Hyun Sun Cho ),성혜영 ( Hye Young Sung ),남관우 ( Kwan Woo Nam ),장재혁 ( Jae Hyuck Chang ),조유경 ( Yu Kyung Cho 대한소화기학회 2010 대한소화기학회지 Vol.55 No.3

목적: 최근 수년간의 임상 경험과 최근 발표들은 Clostridium difficile 대장염(CDC)이 더욱 흔해지고 병인성이 강해짐을 시사한다. 이 연구의 목적은 한국에서 입원 환자의 CDC의 역학적인 특징 변화를 조사하는 것이다. 대상 및 방법: 1998년 1월부터 2007년 12월까지 강남성모병원에서 CDC로 진단받은 환자를 전향 조사했다. Clostridium difficile 세포독성검사에서 양성이거나 내시경 또는 병리 증거가 존재할 경우 CDC로 정의했다. 결과: 연구 기간 동안 총 189명(남자 73명, 여자 116명)이 CDC로 진단되었다. 평균 연령은 63.3세였다. 65세 초과 환자는 103명(54.4%)이었다. 1998년부터 2007년까지 CDC의 유병률은 유의하게 증가했다. CDC의 유병률은 1997-1998년 입원환자 10,000명당 1.9명에서 2006-2007년 입원환자 10,000명당 8.82명으로 증가했다. 163건(86.2%)에서 진단 2개월 이내에 항생제 사용을 확인했다. 사용한 항생제는 평균 2.1종류였고 항생제 사용 기간은 평균 18.8일(1-240일)이었다. Cephalosporin이 가장 많은 131명(80.4%)에서 투여되었고, 다음으로 aminoglycoside는 85명(52.1%), fluoroquinolone은 24명(14.7%), macrolide는 20명(12.3%) 순으로 사용되었다. 가장 많은 항생제 사용 원인으로 수술 전후 예방적 투여(33.3%)와 폐렴(23.3%)이었다. CDC에 대한 초기 항생제 치료 반응률은 82.7% (153/184)였다. Metronidazole에 대한 반응률은 84.3%(145/172)였다. Metronidazole 초치료에 실패한 모든 환자는 vancomycin으로 성공적으로 치료되었다. Vancomycin으로 1차 치료 시 반응률은 80%(4/5)였다. 3명의 환자가 metronidazole과 vancomycin복합 치료에도 불구하고 CDC와 관련하여 사망했다. 결론: 1998년부터 2007년까지 한국에서 입원 환자의 CDC 유병률이 유의하게 증가했다. Background/Aims: Our clinical experience and recent published literatures suggest that Clostridium difficile colitis (CDC) has become more common and potentially more pathogenic in recent years. The aim of study was to evaluate changes in the epidemiological features of CDC in hospitalized patients in Korea. Methods: We retrospectively reviewed all patients of CDC diagnosed at Kangnam St. Mary Hospital from 1998 to 2007. CDC was defined as having a positive C. difficile cytotoxicity assay, or endoscopic or pathologic evidence of CDC. Results: A total of 189 cases (male 73, female 116, mean age 63.3 years) of CDC were diagnosed during the study period. The prevalence of CDC increased from 1.9/10,000 patient admissions in 1998-1999 to 8.82/10,000 patient admissions in 2006-2007. One hundred sixty three indication for cases (86.2%) of patients identified a prior use of antibiotics in the 2 months preceding diagnosis. The most common antibiotic use was prophylactic use during perioperational period (33.3%) followed by pneumonia (23.3%). The overall response rate to initial antibiotics was 82.7%. One hundred seventy two (91%) patients were initially treated with metronidazole. The response rate was 84.3%. All patients with initial failure to metronidazole were successfully treated by vancomycin. The response rate of vancomycin as first treatment was 80%. Three deaths were associated with CDC despite the use of combination of metronidazole and vancomycin. Conclusions: The prevalence of CDC in hospitalized patients in Korea significantly increased from 1998 to 2007. (Korean J Gastroenterol 2010;55:169-174)

Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH-SY5Y cells against oxidative stress

Kim, Sun J.,Yune, Tae Y.,Han, Ching T.,Kim, Young C.,Oh, Young J.,Markelonis, George J.,Oh, Tae H. Wiley Subscription Services, Inc., A Wiley Company 2007 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.85 No.1

<P>The neuroprotective effect of mitochondrial isocitrate dehydrogenase (IDPm), an enzyme involved in the reduction of NADP<SUP>+</SUP> to NADPH and the supply of glutathione (GSH) in mitochondria, was examined using SH-SY5Y cells overexpressing IDPm (S1). S1 cells showed higher NADPH and GSH levels than vector transfectant (V) cells and were more resistant to staurosporine-induced cell death than controls. Staurosporine-induced cytochrome c release, caspase-3 activation, and production of reactive oxygen species (ROS) were significantly attenuated in S1 cells as compared to V cells and reduced by antioxidants, trolox and GSH-ethyl ester (GSH-EE). Staurosporine-induced the release of Mcl-1 from mitochondria that formed a complex with Bim. Mcl-1 was then cleaved to a shortened form in a caspase-3 dependent manner; its release was attenuated far more in S1 than in V cells after staurosporine treatment. Finally, the staurosporine-induced decrease in mitochondrial membrane potential (Δψ<SUB>m</SUB>) was correlated with the time of mitochondrial Mcl-1 release; the loss of Δψ<SUB>m</SUB> was attenuated significantly in S1 cells as compared to that in V cells. These results suggest that the neuroprotective effect of IDPm may result from increases in NADPH and GSH levels in the mitochondria. This, in turn, inhibits mitochondrial ROS production after cytochrome c release, which seems to be mediated through Mcl-1 release. © 2006 Wiley-Liss, Inc.</P>