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Sungok Kim,Jisuk Jeung,Eunjoo H. Lee,Yunghyun Choi 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study investigated the effects of Corni Fructus water extract (CFE) against oxidative stress-induced cell damage in C2C12. The results demonstrated that preincubation of C2C12 with CFE prior to H₂O₂ stimulation inhibited cytotoxicity, comet tail formation, chromatin condensation and phospho-histone γH2AX expression, suggesting that it prevents H₂O₂-induced ROS accumulation, cellular DNA damage and apoptotic cell death. CFE also restored H₂O₂-induced mitochondrial dysfunction and prevented apoptosis by Bax/Bcl-2 ratio and inducing cytosolic release of cytochrome c and degradation of caspase and PARP in H₂O₂-stimulated C2C12. Interestingly, the expression of Nrf2 was significantly increased by CFE in the presence of H₂O₂, which was associated with a marked increase in expression of HO-1. Additionally, the preventive effects of CFE were significantly abolished by zinc protoporphyrin, a HO-1 specific inhibitor, indicating that CFE activates the Nrf2/HO-1 axis in C2C12 to protect against oxidative stress. These findings suggest that CFE may protect muscle cells against oxidative stress-induced injury through activation of the Nrf2/HO-1 signaling pathway.