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Yung-Fu Chang,Sung Jae Shin,유한상,Sean P. McDonough 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.2
Eighty-five complex (85A, 85B and 85C), 35-kDa and superoxide dismutase (SOD) were cloned, expressed and purified as antigens in an enzyme-linked immunosorbent assay (ELISA) to compare the serological reactivity of cows with different shedding levels of Mycobacterium avium subsp. paratuberculosis (MPT). Antibody responses to all recombinant antigens positively increased depending on shedding levels. In particular, antibody responses to the 35 kDa were higher than those to the others in all shedder groups. Also, the mean of O. D. values among Ag 85 complex, 85B showed slightly higher response than others with high sensitivity and specificity in all shedder groups. In receiver operating characteristic (ROC) curve analysis, the result of 35 kDa ELISA yielded an area under the curve value of 0.945 (95% confidence interval = 0.895 − 0.996), which indicated that this 35 kDa is more accurate indicator of MPT infection than other antigens. At the cut-off point recommended by the ROC curve analysis, the sensitivity and specificity of 35 kDa ELISA were higher than those of other antigens with 93.3% and 86.4%, respectively. Finally, a commercially available ELISA kit was used to clarify 200 positive and 200 negative sera. We then re-tested these serum samples with our ELISA test using the 35-kDa antigens. 35 kDa ELISA and commercial kit showed almost similar results in ROC curve analysis even though two of positive sera in commercial kit were negative in 35 kDa ELISA. The sera, which showed difference in the comparison with commercial ELISA kit, they also did not react with 35 kDa in Western blot. These results suggest that a 35-kDa based ELISA can be useful for detecting MPT infection. Eighty-five complex (85A, 85B and 85C), 35-kDa and superoxide dismutase (SOD) were cloned, expressed and purified as antigens in an enzyme-linked immunosorbent assay (ELISA) to compare the serological reactivity of cows with different shedding levels of Mycobacterium avium subsp. paratuberculosis (MPT). Antibody responses to all recombinant antigens positively increased depending on shedding levels. In particular, antibody responses to the 35 kDa were higher than those to the others in all shedder groups. Also, the mean of O. D. values among Ag 85 complex, 85B showed slightly higher response than others with high sensitivity and specificity in all shedder groups. In receiver operating characteristic (ROC) curve analysis, the result of 35 kDa ELISA yielded an area under the curve value of 0.945 (95% confidence interval = 0.895 − 0.996), which indicated that this 35 kDa is more accurate indicator of MPT infection than other antigens. At the cut-off point recommended by the ROC curve analysis, the sensitivity and specificity of 35 kDa ELISA were higher than those of other antigens with 93.3% and 86.4%, respectively. Finally, a commercially available ELISA kit was used to clarify 200 positive and 200 negative sera. We then re-tested these serum samples with our ELISA test using the 35-kDa antigens. 35 kDa ELISA and commercial kit showed almost similar results in ROC curve analysis even though two of positive sera in commercial kit were negative in 35 kDa ELISA. The sera, which showed difference in the comparison with commercial ELISA kit, they also did not react with 35 kDa in Western blot. These results suggest that a 35-kDa based ELISA can be useful for detecting MPT infection.
REVISITING CONSUMER CONTAMINATION: INFLUENCES OF PROXIMITY AND SCOPE OF CONTACT
Fu-Yung Kuan,En-Chi Chang,Sin-Yao Chen 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.8
According to theory of consumer contamination (Argo, Dahl & Morales, 2006), a product, after being touched by a customer, will be disgusted and devalued by the following customer. However, Argo, et al. (2006) considered only a high salience of contact product, i.e., T-shirts, and did not consider low salience of contact products. This study extended the study of Argo, et al. (2006) and examined whether perception of consumer contamination varies between products of different saliences of contact. The gender difference was also considered. The result from an experiment showed that consumers’ reactions to ‘contaminated’ products vary, depending on the salience of contact. The result also shows that female consumers tend to be more sensitive to consumer contamination.
REVISITING CONSUMER CONTAMINATION: INFLUENCES OF PROXIMITY AND SCOPE OF CONTACT
Fu-Yung Kuan,En-Chi Chang,Sin-Yao Chen 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
According to theory of consumer contamination (Argo, Dahl & Morales, 2006), a product, after being touched by a customer, will be disgusted and devalued by the following customer. However, Argo, et al. (2006) considered only a high salience of contact product, i.e., T-shirts, and did not consider low salience of contact products. This study extended the study of Argo, et al. (2006) and examined whether perception of consumer contamination varies between products of different saliences of contact. The gender difference was also considered. The result from an experiment showed that consumers’ reactions to ‘contaminated’ products vary, depending on the salience of contact. The result also shows that female consumers tend to be more sensitive to consumer contamination.
Association of a functional IRF7 variant with systemic lupus erythematosus
Fu, Qiong,Zhao, Jian,Qian, XiaoXia,Wong, Jonathan L. H.,Kaufman, Kenneth M.,Yu, C. Yung,Mok, Mo Yin,Harley, John B.,Guthridge, Joel M.,Song, Yeong Wook,Cho, Soo-Kyung,Bae, Sang-Cheol,Grossman, Jennife Wiley (John WileySons) 2011 Vol.63 No.3
<P>A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE). This study was undertaken to investigate whether genetic polymorphism within IRF7 is a risk factor for the development of SLE.</P>
Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice
Fu, Yan,Tsauo, Jiaywei,Sun, Yucheng,Wang, Zhe,Kim, Kun Yung,Lee, Seung-Hwan,Kim, Dong-Young,Jing, Feifeng,Lim, Dahae,Song, Ho-Young,Hyun, Hoon,Choi, Eun Young Elsevier 2018 Biochemical and biophysical research communication Vol.500 No.3
<P><B>Abstract</B></P> <P>Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons. Del-1-deficient mice had a higher incidence of adhesions, and their adhesions had higher quality and tenacity scores. Del-1 deficiency also led to enhanced inflammation mediators and collagen production. Finally, Del-1 supplementation decreased the incidence and severity of postoperative peritoneal adhesions. Taken together, these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation.</P>
Adult-Onset Genetic Leukoencephalopathies With Movement Disorders
Fu Mu-Hui,Chang Yung-Yee 대한파킨슨병및이상운동질환학회 2023 Journal Of Movement Disorders Vol.16 No.2
Genetic leukoencephalopathies (GLEs) are a group of white matter abnormalities with heterogeneous radiological and phenotypic features. Although these conditions have mostly been described in children, adult-onset cases are increasingly recognized owing to the widespread use of neuroimaging and advances in molecular genetic testing. The disease course is often progressive with a varied spectrum of presentations, trapping neurologists in the dilemma of differential diagnosis. Movement disorders are among the most common symptoms, and their diversity makes diagnosis challenging. In this review, we focus on adult-onset GLEs with movement disorders and offer a step-by-step diagnostic approach by clarifying the phenomenology of movement, advising investigations for acquired causes, describing the clinical and radiological clues to each disease, emphasizing the limitations of advanced molecular testing, and discussing the future application of artificial intelligence. We provide a list summarizing the leukoencephalopathies associated with different categories of movement disorders. In addition to guiding clinicians on how to narrow the list of differential diagnoses with the tools currently available, another aim of this review is to emphasize the inevitable trend toward applying advanced technology in diagnosing these difficult diseases.