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Yang, Yuna,Nam, Sungju,Lee, Won-Yong Elsevier 2018 Microchemical journal Vol.142 No.-
<P><B>Abstract</B></P> <P>A highly sensitive tris(2,2′-bipyridyl)ruthenium(II) [Ru(bpy)<SUB>3</SUB> <SUP>2+</SUP>] electrogenerated chemiluminescence (ECL) biosensor for the detection of ethanol based on ADH and NAD<SUP>+</SUP> cofactor with ionic liquid (IL) doped sol-gel titania-Nafion composite film has been developed. Regardless of the type of the ILs, the incorporation of IL in the composite resulted in the enhancement in both the electron transfer and diffusion rates in the composite modified electrode, thus leading to dramatic increase in ECL intensity. Among several ILs tested, 1-butyl-3-methylimidazolium with chloride counter anion was most effective for the construction of the Ru(bpy)<SUB>3</SUB> <SUP>2+</SUP> ECL biosensor. Two-layer system with the inner layer of Ru(bpy)<SUB>3</SUB> <SUP>2+</SUP> immobilized in IL-titania-Nafion composite film and the outer layer of ADH immobilized in titania-Nafion composite film has been used to maintain the activity of the enzyme and the overall stability of the ECL biosensor. The present biosensor exhibited linear response towards ethanol with a linear dynamic range of 1.2 × 10<SUP>−5</SUP> M–2.5 × 10<SUP>−1</SUP> M and a detection limit of 5.0 × 10<SUP>−6</SUP> M (S/N = 3). The outstanding dynamic range showed the applicability of the present biosensor for ethanol detection not only in human blood but also in a variety of different fields such as alcoholic beverages or other commercially available products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The ECL ethanol biosensor has been developed. </LI> <LI> Ionic liquid was incorporated in sol-gel titania-Nafion composite film. </LI> <LI> 1-Butyl-3-methylimidazolium with chloride was most effective. </LI> <LI> ECL biosensor showed high sensitivity towards ethanol. </LI> <LI> ECL biosensor was applied for ethanol detection in real sample. </LI> </UL> </P>
초등 1학년 발달성 난독 아동의 낱말 해독, 음운인식, 빠른 이름대기, 자소 지식
양유나(Yang, Yuna),배소영(Pae, Soyeong) 한국음성학회 2018 말소리와 음성과학 Vol.10 No.2
This study aims to compare the word decoding skills, phonological awareness (PA), rapid automatized naming (RAN) skills, and letter knowledge of first graders with developmental dyslexia (DD) and those who were typically developing (TD). Eighteen children with DD and eighteen TD children, matched by nonverbal intelligence and discourse ability, participated in the study. Word decoding of Korean language-based reading assessment(Pae et al., 2015) was conducted. Phoneme-grapheme correspondent words were analyzed according to whether the word has meaning, whether the syllable has a final consonant, and the position of the grapheme in the syllable. Letter knowledge asked about the names and sounds of 12 consonants and 6 vowels. The children’s PA of word, syllable, body-coda, and phoneme blending was tested. Object and letter RAN was measured in seconds. The decoding difficulty of non-words was more noticeable in the DD group than in the TD one. The TD children read the syllable initial and syllable final position with 99% correctness. Children with DD read with 80% and 82% correctness, respectively. In addition, the DD group had more difficulty in decoding words with two patchims when compared with the TD one. The DD group read only 57% of words with two patchims correctly, while the TD one read 91% correctly. There were significant differences in body-coda PA, phoneme level PA, letter RAN, object RAN, and letter-sound knowledge between the two groups. This study confirms the existence of Korean developmental dyslexics, and the urgent need for the inclusion of a Korean-specific phonics approach in the education system.
Yang, Jae-Wook,Lee, Do-Kyung,Kim, Yuna,Kang, Byung-Yong,Kim, Kyung-Jae,Ha, Nam-Joo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Enterococcus faecalis and Enterococcus faecium isolated from Korea patients in 1998 and 2005 were tested for susceptibility to nine different antimicrobial agents, including vancomycin and teicoplanin. Polymerase chain reaction (PCR) was used for the detection of several van-comycin resistance genes such as vanA('high level'), varB ('moderate high level'), vanC1 and vanC2 ('low level'). Both E. faecalis and E. faecalis exhibited a resistance of 80% and more than 60% to synercid and mupirocin, respectively. Moreover, an average of 76% of all isolates was resistant to ciprofloxacin, gentamicin, lincomycin, cefotaxime, and meropenem, confirm-ing the multiple drug resistance of most of the isolates. No resistance to vancomycin or teicoplanin was observed in the 998 E. faecalis and E. faecium isolates. However, the 2005 E. faecalis and E. faecium isolates exhibited resistance of 16% and 12% to vancomycin and teicoplanin, respectively. In addition, vanA gene was detected in 4 strains of 2005 E. faecium lisolates, thus showing a high resistance to vancomycin. No other vancomycin resistancegenes, including vanB, vanC1, and varC2, were found in our isolates. In this study, we com-pared the occurrence of antimicrobial resistance and the presence of specific resistance genes in E. faecalis and E. faecalis. The results showed that the 2005 isolates were usually more resistant than the 1998 isolates.