http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Imaging of pulmonary vasculitis.
Chung, Man Pyo,Yi, Chin A,Lee, Ho Yun,Han, Joungho,Lee, Kyung Soo Radiological Society of North America 2010 Radiology Vol.255 No.2
<P>The presence of pulmonary vasculitis can be suggested by a clinical presentation that includes diffuse pulmonary hemorrhage, acute glomerulonephritis, chronic refractory sinusitis or rhinorrhea, imaging findings of nodules or cavities, mononeuritis multiplex, multisystemic disease, and palpable purpura. Serologic tests, including the use of cytoplasmic antineutrophil cytoplasmic antibody (ANCA) and perinuclear ANCA, are performed for the differential diagnosis of the diseases. A positive cytoplasmic ANCA test result is specific enough to make a diagnosis of ANCA-associated granulomatous vasculitis if the clinical features are typical. Perinuclear ANCA positivity raises the possibility of Churg-Strauss syndrome or microscopic polyangiitis. Imaging findings of pulmonary vasculitis are diverse and often poorly specific. The use of a pattern-based approach to the imaging findings may help narrow the differential diagnosis of various pulmonary vasculitides. Integration of clinical, laboratory, and imaging findings is mandatory for making a reasonably specific diagnosis.</P>
정인용,정현우,김태환,진수일,윤택구 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.1
국내 原子力 産業의 施設增大로 放射線核種汚染의 가능성이 날로 증가되고 있음에도 불구하고 종사자 및 인근주민에 대한 診療對策에 관한 연구가 전무한 실정에 있어 이에 대한 기초자려마련의 일환인 應急處置方案을 수립코자 58CoCl2 1μCi를 마우스 (NIH-(GP))의 腹腔內에 投與한 후 CoNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, saline 5ml등을 각각 投與하였으며, cobalt의 全身殘存量, 體內分布 및 尿內 含有된 量을 測定하기 위해 投與 後 4, 8, 12, 48시간, 그리고 7일에 MCA의 Ge-detector로 放射能을 計測하였고, 또한 각 實質臟器內 殘存된 cobalt의 放射能을 測定하기 위하여 각 group당 6마리의 마우스를 屠殺解體하여 測定하였던바 다음과 같은 결론을 얻었다. CoNa3 DTPA 處置群에서는 汚染된 放射性 cobalt의 全身殘存率의 減少 및 排泄率 增加에 유효한 效果가 있었으며, system contamination에 대한 방어효과는 CoNa3 DTPA, CoNa3 DTPA 그리고 saline 順으로 유효하였다. 결론적으로 본 실험결과로 볼 때 放射性 cobalt의 體內汚染에 대한 緊扱措置는 CoNa3 DTPA와 다량의 물을 동시에 投與함으로써 體內汚染된 放射性 cobalt의 排泄을 促進시킬 것으로 사료된다. In case of the acute intake of radionuclide, an early medical treatment may be necessary, but the little is established the procedures to decontaminate the victims of internal contamination in Korea. The purpose of the present investigation is to study chemical agents to remove radiocobalt from the victims and to provide a more reliable procedure for the treatment. The removals of radiocobalt from the NIH-(GP)mice injected intraperitoneally with lμCi of 58Co as CoCl2 were investigated with doses of either CaNa3 DTPA 8.4mg/0.2ml saline, CoNa3 DTPA 8.4mg/0.2ml saline, or saline 5ml. The radioactivity was determined by MCA and Ge-detector on 4, 8, 12, 48 hours and 7 days for the whole body, organ distribution and urine excretion. Six mice per each group were sacrificed for the measurement of cobalt retention in the parenchymal tissue. The cobalt trisodium chelate had a pronounced effect on reducing the whole body retention and increasing the excretion rate. Regarding to the systemic protective effects, CoNa3 DTPA, CaNa3 DTPA and saline were effected significantly in order. In conclusion, the extrapolations from these results to human were suggested that the rapid administration of cobalt trisodium chelate and an amount of saline to the contaminated person after internal contamination of radiocobalt were markedly increasing the decontamination effects.
Cortisone의 局所投與가 免疫家兎淋巴結節에 미치는 影響에 關한 實驗的硏究
尹重鎭 고려대학교 의과대학 1964 고려대 의대 잡지 Vol.1 No.2
There have been numerous investigations and report concerning effects of antibody production which bases upon number of plasmacell. The purpose of this study is to investigate the pathohistological changes of the affected lymohnodes and alteration of the lymphfluid in rabbits which might be influenced by concurrent administration of the cortisone and the antigen. Materials and Methods The animal used for this study is healthy white rabbits, weighing around 2.5Kg. For immunization, 0.2 cc. of horse serum is injected into the subcutaneous tissue of the right foot pad 3 times every other day. After 7 days from the completion of the initial immunization, 0.2 cc horse serum was reinjected for the purpose of producing for reimmunization. Another Set of experiment consisted of mixed injection of cortison acetate and horse serum into the right food pad as same methods. After the completion of injection, animals were examined for lymphfluid at regular intervals of 1 day, 2 days, 4 days, 7 days, 10 days and 14 days respectively. Smear and imprinted specimens were made. This specimens were fixed in Methanol and 10 % neutral formaline. The tissues were stained routinley with hematoxylin & eosin and Unna-Pappenheim, and the smears & imprinted specimens ,were stained with Giemsa and Unna-Pappenheim. Results and Summary 1. The result of study showed marked increasing of W.B.C., plasmacyte, preplasmacyte and plasmablast in simple immunized group. However, No notable alteration in cortisone treated group. 2. Macroscopically, the lymphnodes were swelling in simple group, but not remarkeble in cortisone treated group. 3. In simple immunized group, the plasmacytes, reticulum cells and lymphocyte in lymphnodes were markedly increased which showed maximum value (level) on 4-7 days from the completion of the initial immunization, and cortisone treated group did not show any notable difference. 4. From the results obtained by above experiments, it is the opinion of this investigator that the cortisone was definitely inhibited to the reactions of secondary immunization.
Park, Yun Kyung,Lee, Mi Ji,Kim, Jae Ha,Lee, Jin Soo,Park, Rae Woong,Kim, Gyeong-Moon,Chung, Chin-Sang,Lee, Kwang Ho,Kim, June Soo,Lee, Soo-Youn,Bang, Oh Young Elsevier 2017 Journal of stroke and cerebrovascular diseases Vol.26 No.6
<P><B>Background</B></P> <P>Warfarin has a narrow therapeutic window. We hypothesized that genetic factors related to warfarin metabolism (<I>CYP2C9</I>) and activity (<I>VKORC1</I>) would show stronger associations than modifiable factors with the quality of anticoagulation control and risks for thromboembolism and hemorrhage.</P> <P><B>Methods</B></P> <P>In this retrospective cohort analysis, clinical and genetic data were collected from 380 patients with atrial fibrillation (AF) who were followed for an average observation period of 4 years. We evaluated the factors associated with time in therapeutic range (TTR, international normalized ratio [INR]: 2-3) and vascular events (either thromboembolic or hemorrhagic), including both genetic (<I>CYP2C9</I> and <I>VKORC1</I> genotype) and modifiable factors (anticoagulation service and warfarin dose assessment interval).</P> <P><B>Results</B></P> <P>The genotypic frequency of <I>CYP2C9*3</I> (rs1057910) was 9.5% and that of <I>VKORC1</I> 1173C>T (rs9934438) was 16.3%. TTR showed dependence on <I>VKORC1</I> polymorphism: TTR was higher in carriers of the <I>VKORC1</I> 1173C>T than of the <I>VKORC1</I> TT genotype (61.7 ± 16.0% versus 56.7 ± 17.4%, <I>P</I> = .031). Multivariate testing showed that the <I>VKORC1</I> genotype and anticoagulation service were independently related to labile INRs (TTR <65%). Vascular events were observed in 66 patients (18.4%) during the study period. A Cox proportional hazard model showed that the use of anticoagulation service and patients' characteristics, such as AF-thromboembolic risk (CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score: Congestive heart failure, Hypertension, Age 75 years or older, Diabetes mellitus, previous Stroke or transient ischemic attack, Vascular disease, Age 65 to 74 years, female) and consequence (neurologic disability), but not genetic factors, were independently associated with vascular events.</P> <P><B>Conclusions</B></P> <P>Both genetic factor (<I>VKORC1</I> genotype) and clinical efforts (anticoagulation service) influenced the quality of anticoagulation control. However, clinical events were more strongly associated with patient characteristics and clinical efforts than with genetic factors.</P>