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Yujie Wang,Shan Xu,Lidan Tang,Jinhong Gong,Dan Su,Hao Yang 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.10
The global prevalence of diabetes and its related complications has increased drastically and is currently aworldwide health challenge. There is still an urgent need for safe and effective natural products and supplements as alternativeand/or adjunctive therapeutic interventions. Nowadays, people pay more and more attention to the nutritional and medicinalvalue of food ingredients. As one of the most widely employed spices in cooking, pepper also has novel medicinal valuesattributed to its main component, piperine (Pip). Pip is an amide alkaloid with pleiotropic properties such as antiinflammatory,antioxidant, anti-cancer, and other related activities. Recently, Pip has received increasing scientific attentiondue to its antidiabetic and related complication properties. However, the values of existing studies are limited due to beingscattered and unsystematic. The present study reviewed the therapeutic potential and possible mechanisms of Pip in diabetesand related complications, with the aim of providing promising candidates for the development of novel and effectivealternative and/or adjunctive nutraceutical agents for the management of diabetes.
A Learning-based Power Control Scheme for Edge-based eHealth IoT Systems
( Haoru Su ),( Xiaoming Yuan ),( Yujie Tang ),( Rui Tian ),( Enchang Sun ),( Hairong Yan ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.12
The Internet of Things (IoT) eHealth systems composed by Wireless Body Area Network (WBAN) has emerged recently. Sensor nodes are placed around or in the human body to collect physiological data. WBAN has many different applications, for instance health monitoring. Since the limitation of the size of the battery, besides speed, reliability, and accuracy; design of WBAN protocols should consider the energy efficiency and time delay. To solve these problems, this paper adopt the end-edge-cloud orchestrated network architecture and propose a transmission based on reinforcement algorithm. The priority of sensing data is classified according to certain application. System utility function is modeled according to the channel factors, the energy utility, and successful transmission conditions. The optimization problem is mapped to Q-learning model. Following this online power control protocol, the energy level of both the senor to coordinator, and coordinator to edge server can be modified according to the current channel condition. The network performance is evaluated by simulation. The results show that the proposed power control protocol has higher system energy efficiency, delivery ratio, and throughput.
A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins
Diao, Jiajie,Ishitsuka, Yuji,Lee, Hanki,Joo, Chirlmin,Su, Zengliu,Syed, Salman,Shin, Yeon-Kyun,Yoon, Tae-Young,Ha, Taekjip Nature Publishing Group, a division of Macmillan P 2012 NATURE PROTOCOLS -ELECTRONIC EDITION- Vol.7 No.5
SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins are a highly regulated class of membrane proteins that drive the efficient merger of two distinct lipid bilayers into one interconnected structure. This protocol describes our fluorescence resonance energy transfer (FRET)-based single vesicle-vesicle fusion assays for SNAREs and accessory proteins. Both lipid-mixing (with FRET pairs acting as lipophilic dyes in the membranes) and content-mixing assays (with FRET pairs present on a DNA hairpin that becomes linear via hybridization to a complementary DNA) are described. These assays can be used to detect substages such as docking, hemifusion, and pore expansion and full fusion. The details of flow cell preparation, protein-reconstituted vesicle preparation, data acquisition and analysis are described. These assays can be used to study the roles of various SNARE proteins, accessory proteins and effects of different lipid compositions on specific fusion steps. The total time required to finish one round of this protocol is 3??6 d.
Tianlin Ma,Manyun Yin,Chunyang Su,Ningfei Guo,Xiangxiang Huang,Zhen Han,Yujie Wang,Gangling Chen,Zhi Yun 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-
The surplus production of glycerol as a byproduct of biodiesel has become an urgent problem for the sustainabilityof the biodiesel industry. The catalytic transformation of glycerol to value-added chemicalshas attracted the attention of researchers worldwide over the last decade. Among them, selective dehydrationof glycerol to acrolein has gained interest from both academic researchers and industrial applications. Molecular sieves have been considered as the most promising catalysts for industrialapplications of glycerol dehydration. However, there is no systematic summary for the research carriedout for this reaction over molecular sieve catalysts. This work provides a comprehensive and criticalreview of glycerol dehydration to acrolein over molecular sieve catalysts, including ZSM-5, ZSM-11,MCM-22, MCM-41, SBA-15, SAPO-34, HY and Hb. The key technical problems that restrict its industrialapplication are the easy coking and poor stability of the molecular sieves. In particular, the pore size, porestructure, acid amount, acid strength, acid type and reaction conditions that influence the dehydrationperformance are discussed in detail. Furthermore, the reaction mechanism, reaction kinetics, reactionthermodynamics and future research directions for catalyst design and engineering are also presented. This review will deepen our understanding of the catalytic dehydration of glycerol to acrolein and provideguidance for researchers on the rational design of molecular sieve catalysts.
Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1.
Lai, Ying,Diao, Jiajie,Liu, Yanxin,Ishitsuka, Yuji,Su, Zengliu,Schulten, Klaus,Ha, Taekjip,Shin, Yeon-Kyun National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.4
<P>Fusion pore formation and expansion, crucial steps for neurotransmitter release and vesicle recycling in soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent vesicle fusion, have not been well studied in vitro due to the lack of a reliable content-mixing fusion assay. Using methods detecting the intervesicular mixing of small and large cargoes at a single-vesicle level, we found that the neuronal SNARE complexes have the capacity to drive membrane hemifusion. However, efficient fusion pore formation and expansion require synaptotagmin 1 and Ca(2+). Real-time measurements show that pore expansion detected by content mixing of large DNA cargoes occurs much slower than initial pore formation that transmits small cargoes. Slow pore expansion perhaps provides a time window for vesicles to escape the full collapse fusion pathway via alternative mechanisms such as kiss-and-run. The results also show that complexin 1 stimulates pore expansion significantly, which could put bias between two pathways of vesicle recycling.</P>
Novel extraction technologies and potential applications of egg yolk proteins
Luping Gu,Yufang Liu,Wanqiu Zhang,Junhua Li,Cuihua Chang,Yujie Su,Yanjun Yang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.2
The high nutritional value and diverse functional properties of egg yolk proteins have led to its widespread use in the fields of food, medicine, and cosmetics. Various extraction methods have been reported to obtain the proteins from egg yolk, however, their utilization is limited due to the relatively low extraction efficiency and/or toxic solvents involved. Several simpler and greener technologies, especially physical fields (ultrasound), have been successfully developed to improve the extraction efficiency. The egg yolk proteins may exert multiple biological activities, enabling them to be a promising tool in improve human health and wellbeing, such as anti-obesity, anti-atherosclerosis, anti-osteoporosis, diagnosis and therapy for SARS-CoV-2 infections. This article summarizes the novel extraction technologies and latest applications of the egg yolk proteins in the recent 5 years, which should stimulate their utilization as health-promoting functional ingredients in foods and other commercial products.