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Yuji Hotta,Naoya Ieda,Ayako Fukamoto,Tomoya Kataoka,Yoshihiro Kawade,Yasuhiro Maeda,Hidehiko Nakagawa,Kazunori Kimura 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.3
Purpose: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, light-controllable nitric oxide (NO) releaser. Materials and Methods: Fifteen-week-old male Wistar-ST rats were used. The penile corpus cavernosum was prepared and used in an isometric tension study. After noradrenaline (10-5 M) achieved precontraction, the penile corpus cavernosum was irradiated by light (470–500 nm) with and without NOBL-1 (10-6 M). In addition, we noted rats' responses to light with vardenafil (10-6 M), a phosphodiesterase-5 (PDE-5) inhibitor. Next, responses to light in the presence of a guanylate cyclase inhibitor, ODQ (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (10-5 M), were measured. All measurements were performed in pretreated L-NAME (10-4 M) conditions to inhibit endogenous NO production. Results: Corpus cavernosal smooth muscle, precontracted with noradrenaline, was unchanged by light irradiation in the absence of NOBL-1. However, in the presence of NOBL-1, corpus cavernosal smooth muscle, precontracted with noradrenaline, relaxed in response to light irradiation. After blue light irradiation ceased, tension returned. In addition, the light response was obviously enhanced in the presence of a PDE-5 inhibitor. Conclusions: This study showed that rat corpus cavernosal smooth muscle relaxation can be light-controlled using NOBL-1, a novel, light sensitive NO releaser. Though further in vivo studies are needed to investigate possible usefulness, NOBL-1 may be prove to be a useful tool for erectile dysfunction therapy, specifically in the field of penile rehabilitation.
Kunihiro SUZUKI,Yoko TADA,Yuji KATAOKA,Tsutomu NAGAYAMA 대한전자공학회 2009 Journal of semiconductor technology and science Vol.9 No.1
Monte Carlo simulation is widely used for predicting ion implantation profiles in amorphous targets. Here, we compared Monte Carlo simulation results with a vast database of ion implantation secondary ion mass spectrometry (SIMS), and showed that the Monte Carlo data sometimes deviated from the experimental data. We modified the electron stopping power model, calibrated its parameters, and reproduced most of the database. We also demonstrated that Monte Carlo simulation can accurately predict profiles in a low energy range of around 1 keV once it is calibrated in the higher energy region.
Suzuki, Kunihiro,Tada, Yoko,Kataoka, Yuji,Nagayama, Tsutomu The Institute of Electronics and Information Engin 2009 Journal of semiconductor technology and science Vol.9 No.1
Monte Carlo simulation is widely used for predicting ion implantation profiles in amorphous targets. Here, we compared Monte Carlo simulation results with a vast database of ion implantation secondary ion mass spectrometry (SIMS), and showed that the Monte Carlo data sometimes deviated from the experimental data. We modified the electron stopping power model, calibrated its parameters, and reproduced most of the database. We also demonstrated that Monte Carlo simulation can accurately predict profiles in a low energy range of around 1keV once it is calibrated in the higher energy region.
Kunihiro SUZUKI,Yoko TADA,Yuji KATAOKA,Tsutomu NAGAYAMA 대한전자공학회 2009 Journal of semiconductor technology and science Vol.8 No.1
Monte Carlo simulation is widely used for predicting ion implantation profiles in amorphous targets. Here, we compared Monte Carlo simulation results with a vast database of ion implantation secondary ion mass spectrometry (SIMS), and showed that the Monte Carlo data sometimes deviated from the experimental data. We modified the electron stopping power model, calibrated its parameters, and reproduced most of the database. We also demonstrated that Monte Carlo simulation can accurately predict profiles in a low energy range of around 1 keV once it is calibrated in the higher energy region.
Mitsukuri, Yuki,Hara, Ryoichi,Kita, Hiroyuki,Watanabe, Keiichi,Mori, Kenjiro,Kataoka, Yasuhiro,Kogure, Eiji,Mishima, Yuji The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.2
A surge of needs for the low carbon society promotes a spread of electric vehicle (EV). EVs could be charged at night simultaneously, as a result, severe voltage drop may happen. The authors have proposed the method which can compensate the voltage drop caused by EV charging by means of adjusting charging schedules and controlling reactive power. And, we have confirmed the effectiveness of the method by estimating steady state in order to figure out the limitation of the control capability. In this paper, from a practical viewpoint, we propose the method to consider dynamic behavior. In this method, the EV can not only finish charging effectively but also control minimal reactive power to keep admissible voltage with monitoring system voltage.