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Yuanyuan Fu,Jing Dong,Jianan Wang,Mingdan You,Lingling Wei,Hui Fu,Yuan Wang,Jie Chen 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.6
Di-(2-ethylhexyl) phthalate (DEHP) is an ubiquitous environmental contaminant because of its extensive use in plastics and its persistence. As an environmental endocrine disruptor, it is suspected to interfere with neurodevelopment in people. However, evidence of the effects of maternal DEHP exposure on cerebellar development in offspring is scarce. The objective of this study was to investigate maternal exposure to DEHP and its effect on apoptosis of cerebellar granule cells (CGCs) and related mechanisms. Pregnant Wistar rats were administrated DEHP (0, 30, 300 and 750 mg/kg/d) by gavage from gestational day (GD) 0 to postnatal day (PN) 21. Primary CGCs were also exposed to mono-(2-ethylhexyl) phthalate (MEHP), the main metabolite of DEHP, for 24 h with concentrations of 0, 25, 100 and 250 μM. The CGCs of male offspring from 300 and 750 mg/kg/d DEHP exposure groups showed significantly increased apoptosis. In addition, the PI3K/AKT signaling pathway was inhibited in the male offspring of the 300 and 750 mg/ kg/d DEHP exposure groups. However, effects on female pups were not obvious. Apoptosis was also elevated and the PI3K/AKT signaling pathway was inhibited after primary CGCs were exposed to MEHP. Furthermore, apoptosis was reduced after treatment with the PI3K/AKT signaling pathway activator, insulin-like growth factor (IGF) 1, and increased after treatment with LY294002, an inhibitor of the PI3K/AKT signaling pathway. These results suggested that maternal DEHP exposure induced apoptosis in the CGCs of male pups via the PI3K/AKT signaling pathway, and the apoptosis could be rescued by IGF1 and aggravated by LY294002.
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Yuanyuan Qin,Yifei Wang,Jin Liu,Fengfeng Chen,Aiying Yao,Zhanchun Chen,Fu Junyu 한국고분자학회 2022 Macromolecular Research Vol.30 No.12
The mechanical properties of functionalized graphene/polyethylene (f- GRA/PE) composites and graphene/polyethylene (GRA/PE) composites were studied based on the crystallized models with the molecular dynamics simulation in this paper. The effects of GRA and f-GRA with different mass fractions on the mechanical properties of polyethylene were considered. The results showed that the adsorption capacity of polyethylene molecular chains of f-GRA is stronger, the compatibility of f-GRA/PE system is higher with decreasing the interface distance, and the dynamic property of molecular chain is weaker with reducing the radius of gyration of f-GRA/ PE. Furthermore, the reduction of mechanical energy consumption results in the increase of wear resistance of the system, which is more obvious when the mass fraction of f-GRA increases. Finally, the influence of different tensile rates on the composite system was studied. It was found that during the tensile process, the ability of the composite material to resist deformation in the stretching direction is enhanced, and the functionalized graphene inhibits the movement of the molecular chain due to the adsorption force, which improves the yield stress of the f-GRA/PE composite material, thereby increasing the tensile strength. Tensile rate has a certain effect on mechanical properties, and elastic modulus and yield stress increase with the increase of strain rate.
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Corticosterone Regulates the Expression of Neuropeptide Y and Reelin in MLO-Y4 Cells
Yuanyuan Ma,Hang Wang,Xiangnan Wu,Jing Fu,Jiefei Shen,Xiaoyu Li 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.6
Osteocytes that have a dendritic appearance are widely believed to form a complex cellular network system and play crucial roles in mechanotransduction as a principal bone mechanosensor, which is the basis of their neuronal-like biology, as previously reported. Neuropeptide Y (NPY) and reelin mRNA, which are brain-specific neurogenic markers, have been identified in osteocytes. However, changes in the production of NPY and reelin in response to specific biochemical stimulation are unknown. In this study, we investigated the in vitro effect of corticosterone, one of the endogenous glucocorticoids, on the expression of NPY and reelin in the MLO-Y4 osteocyte cell line. Cells were treated with corticosterone at different concentrations (10-9 M-10-5 M) for 1, 3, 6, 12 and 24 h. As revealed, corticosterone reduced the MLO-Y4 cell viability and pro-liferation in a dose- and time-dependent manner based on an MTT assay and a Vi-CELL analyzer. The cells were then incubated with corticosterone (10-6 M), and the NPY and reelin expression levels were detected at 1, 3, 6, 12 and 24 h using real-time PCR and Western blot analysis. These results demonstrated that at the gene and the protein levels, corticosterone significantly upregulated the NPY and reelin expression in a time-dependent manner. The application of a glucocorticoid receptor antagonist, RU486, reversed the reduced cell viability and the increased expression of NPY and reelin that were caused by corticosterone. To the best of our knowledge, this is the first report to verify that corticosterone regulates the NPY and reelin expression in osteocytes.
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Xuezhi Li,Yuanyuan Qin,Haojie Li,Guangjun Liu,Junyu Fu,Feng Li,Zhanchun Chen 한국고분자학회 2023 Macromolecular Research Vol.31 No.9
The processability and practical applications of poly (butylene adipate-co-terephthalate) (PBAT) /poly (lactic acid) (PLA) blends are limited due to their lower miscibility. To investigate the miscibility of various PBAT/PLA composite ratios and the mechanism of miscibility between them, PBAT/PLA blends with different ratios were prepared using the melt mixing method. A combination of multi-scale simulations and experiments were employed to investigate the miscibility of the composites. Molecular dynamics simulations analyzed PBAT/PLA mixtures that are incompatible and showed the molecular basis of their incompatibility through the radial distribution function (RDF). The degree of miscibility of different ratios of PBAT/PLA composites was described using the Flory–Huggins interaction parameter, indicating that the 50/50 PBAT/PLA blend has the worst miscibility. Mesoscopic dynamics described the mesoscopic morphology of PBAT and PLA blends visually. The results obtained from the simulations were consistent with scanning electron microscope (SEM) and differential scanning calorimeter (DSC) experiments, indicating the simulations' reliability. This work provides a molecular perspective on the mechanism of thermodynamic insolubility of PBAT and PLA, which can inspire future PBAT/PLA hybrid modifications.
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Lu, Yonggang,Wang, Xiuli,Fu, Qiang,Zhao, Yuanyuan,Zhu, Rongsheng Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.7
Lead alloy is used as coolant in Lead-based cooled Fast Reactor (LFR). The natural characteristics of lead alloy are combined with the simple structural design of LFR. This constitutes the inherent safety characteristics of LFR. The main work of this paper is to take the main coolant pump (MCP) in the lead-cooled fast reactor (LFR) as the research object, and to study the flow pattern distribution of the internal flow field under the reverse rotation pump condition, the reverse rotation positive-flow braking condition and the reverse rotation negative-flow braking condition. In this paper, the double-outlet volute type and the space guide vane are selected as the potential designs of the CLEAR-I MCP. In this paper, the CFD method is used to study the potential reverse accident of the MCP. It is found that the highest flow velocity in the impeller appears at the impeller outlet, and the Q-H curves of the two design programs basically coincide. The space guide vane type MCP has better hydraulic performance under the reverse rotation positive-flow condition, the Q-H curves of the two designs gradually separate with increasing flow rate, and the maximum flow velocity inside the space guide vane type MCP is obviously lower than that of the double-outlet volute type. For the reverse rotation test of MCP, only the condition of the forward rotating pump of the main coolant pump is tested and verified. For the simulation of the MCP in LBE medium, it proved that the turbulence model and basic settings selected in the simulation are reliable.
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Ying Su,Xiaoqin Wang,Yuanyuan Fu,Xianjun Zheng,Gaoshuai You 한국자원공학회 2018 Geosystem engineering Vol.21 No.4
After studying the development law of surface settlement induced by excavation of foundation pit and the characteristics of the settlement curve, the paper introduces the idea of combination forecasting based on S-shaped growth curves and establishes the weight combination prediction model, which is applied to the actual project to verify the rationality of the model. Results show that the model cannot only reflect the settlement development process along with time, but also predict the surface settlement accurately. In addition, the combination prediction model is more superior to other single ones, and provides an effective and practical method for surface settlement forecasting.
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Biological Control of Apple Ring Rot on Fruit by Bacillus amyloliquefaciens 9001
Yan Li,Li-Rong Han,Yuanyuan Zhang,Xuechi Fu,Ruhong Mei,Qi Wang,Lixia Zhang,Xinyi Chen 한국식물병리학회 2013 Plant Pathology Journal Vol.29 No.2
Apple ring rot disease, caused by Botryosphaeria dothidea (Moug. ex. Fr) Ces. et de Not., is one of the most important diseases on apple fruits. In this study, strain 9001 isolated from healthy apple fruits from an infested orchard was evaluated for its biocontrol activity against apple ring rot in vitro and in vivo. Strain 9001 showed obvious antagonistic activity to B. dothidea YL-1 when plated on potato dextrose agar. Soaking healthy apples in the bacterial suspensions of strain 9001 prior to artificial inoculation of fungal pathogen resulted in a dramatic decrease in disease incidence when compared to the control. Moreover, either field application in the growth season or postharvest treatment of apples from infected orchards with bacterial suspensions of strain 9001 resulted in significantly reduced disease incidence within the storage period for 4 months at room temperature. Based on the phylogenetic analysis of 16S rRNA and the gyrA gene, strain 9001 was identified as Bacillus amyloliquefaciens. These results indicated that B. amyloliquefaciens 9001 could be a promising agent in biocontrol of apple ring rot on fruit, which might help to minimize the yield loss of apple fruit during the long postharvest period.
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Biological Control of Apple Ring Rot on Fruit by Bacillus amyloliquefaciens 9001
Li, Yan,Han, Li-Rong,Zhang, Yuanyuan,Fu, Xuechi,Chen, Xinyi,Zhang, Lixia,Mei, Ruhong,Wang, Qi The Korean Society of Plant Pathology 2013 Plant Pathology Journal Vol.29 No.2
Apple ring rot disease, caused by Botryosphaeria dothidea (Moug. ex. Fr) Ces. et de Not., is one of the most important diseases on apple fruits. In this study, strain 9001 isolated from healthy apple fruits from an infested orchard was evaluated for its biocontrol activity against apple ring rot in vitro and in vivo. Strain 9001 showed obvious antagonistic activity to B. dothidea YL-1 when plated on potato dextrose agar. Soaking healthy apples in the bacterial suspensions of strain 9001 prior to artificial inoculation of fungal pathogen resulted in a dramatic decrease in disease incidence when compared to the control. Moreover, either field application in the growth season or postharvest treatment of apples from infected orchards with bacterial suspensions of strain 9001 resulted in significantly reduced disease incidence within the storage period for 4 months at room temperature. Based on the phylogenetic analysis of 16S rRNA and the gyrA gene, strain 9001 was identified as Bacillus amyloliquefaciens. These results indicated that B. amyloliquefaciens 9001 could be a promising agent in biocontrol of apple ring rot on fruit, which might help to minimize the yield loss of apple fruit during the long postharvest period.
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