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중금속 이온 존재 하에서의 아스코르브산 자동산화반응에 대한 단백질의 영향
김미옥,유리나 울산대학교 2002 생활과학논문집 Vol.4 No.1
Effects of superoxide dismutase(SOD), catalase, and such other proteins as bovine serum albumin(BSA), ovalbumin, lysozyme, and γ-globulin on the autoxidation rates of L-ascorbic acid(AsA) in the presence of heavy metal ions in aqueous solution and buffer solution were studied. AsA was dissolved in a ultra-refined water and 0.07 M potassium phosphate buffer (pH 7.4, treated Chelex-100) at a concentration of 50μM and 5 μM Fe(Ⅲ) or 0.1 μM Cu(Ⅱ) was added, and a oxygen gas was bubbled through the solution at a flow rate of 200 ml/min at 35℃. The amount of remaining AsA in the reaction mixture was determined by using a UV spectrophotometer(at 265 nm). It was confirmed that the ratio of remaining AsA was significantly larger in the presence of SOD, catalase, BSA, ovalbumin, lysozyme, and γ-globulin than in the absence of proteins. It was suggested that the non-enzymatic effects of SOD, catalase and some other proteins might be involves in the stabilization of AsA.
김경애,정유진,안나리,장혁기 서울여자대학교 자연과학연구소 2013 자연과학연구논문집 Vol.25 No.-
We reviewed literatures on human brain activity on exercise. It was proved that exercise activate brain function through various equipments. Among methods to evaluate brain activation, there are Electroencephalography (EEG), Magnetoencephalography (MEG), transcranial doppler sonography (TCD), Magnetic resonance imaging (MRI), Near Infrared Spectroscopy (NIRS) methods. There were different characteries in each measurement methods to demonstrate exercise effects. NIRS is a spectroscopic method that uses the near infrared region of the electromagnetic spectrum. According to using brain scanning equipments involved NIRS, moderate exercise increased frontal lobe (specially prefrontal cortex) and improves cognitive performance. This review will be discussed about brain activation and cognitive functions.
( Yu Ri Kim ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options. Objectives: To evaluate a new-formula shampoo that contains natural ingredients, extract of Rosa centifolia petals and epigallocatechin gallate (EGCG), that exert antioxidative, anti-inflammatory and sebum secretion inhibitory effects, and antifungal agents for the treatment of scalp seborrheic dermatitis. Methods: Seventy-five patients were randomized into three groups: new-formula shampoo, 2% ketoconazole shampoo and 1% zinc-pyrithione shampoo. Clinical severity scores, sebum levels, user satisfaction and irritation were assessed at week 0, week 2 and week 4 after.Results: The efficacy of the new-formula shampoo was comparable to that of both the 1% zinc-pyrithione shampoo and the 2% ketoconazole shampoo. Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared to the 2% ketoconazole shampoo. However, the new-formula shampoo did not exhibit the previously reported sebum inhibitory effect. Conclusion: Extract of Rosa centifolia petals or EGCG could be useful ingredients in treatments for scalp seborrheic dermatitis.
P279 : The effects of freeze dried extract of dangyuja (citrus grandis osbeck) on melanogenesis
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Although previous studies have identified that both the fruit and leaf of dangyuja (Citrus grandis Osbeck) exhibits anticancer, antioxdant and anti-inflammatory effect, the inhibitory effect of melanogenesis have not been reported. Objectives: In this study, freeze dried extract of dangyuja was evaluated for their potential to inhibit melanogenesis. Methods: Cytotoxicity and melanin content in mouse B16F10 melanoma cells were assayed after treatment with the freeze dried extracts of dangyuja. Results: Freeze dried extracts of dangyuja strongly decreased the tyrosinase activity for catalysis of L-dihydroxyphenylalanine (L-DOPA) oxidation in a dose- dependent manner. The results demonstrate that extracts possessed low cytotoxic activity and that melanin content was reduced. Conclusion: Freeze dried extracts of dangyuja is a safe natural materials that show an effective inhibition of melanogenesis. These results suggest that freeze dried extracts of dangyuja can be considered as an effective skin whitening reagent for application in cosmetics.
P135 : Analysis of the safety and efficacy of three natural extracts in cosmetics
( Yu Na Lee ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The function of sebum in human is reducing water loss from the skin``s surface and protecting the skin from infection by microorganism. However, when there is excessive secretion of sebum, it will cause black heads and expansion of the pores so that waste will be accumulated. Objectives: To develop cosmetics for sebum removal and pore improvement that can improve limitations of the existing products. The ingredients include Diospyros kaki (D. kaki ), Castanea crenata (C. crenata), and Polygonum cuspidatum (P. cuspidatum) and to verify the safety and human efficacy evaluation. Methods: Bacteria microbial limit test and patch test performed with 31 participants. Also, with 23 participants who have oily skin, efficacy evaluation was performed. Changes in the amount of sebum, moisture, dead skin condition, blackhead, skin roughness between before and after the test were compared for control group. Results: As a result of safety assessment, there was no pathogenic microorganism for microbial limit test and, there was no skin reactions for patch test. For changes in the amount of sebum and black head from efficacy evaluation,there was temporary improvement for the experimental group. For the amount of moisture, dead skin, and skin roughness of the experimental group showed improvement. Conclusion: When being complemented with body application test for long-term usage, they can be used as natural ingredients when cosmetic manufacturers or sellers are developing new products.
P226 : Sensitive skin in Korean population
( Yu Ri Kim ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Sensitive skin is characterized by the occurrence of sensations of tingling, prickling, heat, burning, pain or itching and, on occasion, erythema in response to multiple physical, chemical or hormonal factors that do not have irritant properties by themselves. Objectives: This study sought to identify the proportion of sensitive skin and their charicteristics in Korean population. Methods: Representative nationwide samples of the Korean populations aged 18 and over were selected. The individuals were questioned by telephone and selected as per the quotas method. Results: Among the 1000 individuals, 55.3% of men and 59.4% of women answered “sensitive” or “very sensitive”. The difference between the 2 sexes is significant (p<0.02). The sensitive skin group are 2 to 4 times more to declare dermatosis, and are 2 or 3 times more reactive to environmental factors, cosmetics and food intake compared with the non-sensitive skin group. Conclusion: 56.8% of Korean appear to have sensitive skin. It is the highest prevalence among the countries reporting theirs. Respondents complaining of sensitive skin appeal more reactive skin to unexpected factors than those with non-sensitive skin. Dermatologists should therefore routinely question their patients’ skin sensitivity and provide them more care.
( Yu Ri Kim ),( Hae Jeong Youn ),( Min Jung Kim ),( Soo Young Kim ),( Nam Kyung Roh ),( Ho Jung Jung ),( Jae Wook Jung ),( Yu Na Lee ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: In the dermis, fibroblasts play a critical role in maintaining homeostasis. UV triggers apoptosis and growth arrest in fibroblasts. Therefore, UV radiation is one of the major inducers of disorders of the dermis. Troxerutin is a derivative of the natural bioflavonoid. As troxerutin has been shown to have radioprotective, anti-inflam¬matory and antioxidant effects, it seems likely that troxerutin may protect cells against UV-induced oxidative stress and DNA damage. Objectives: To investigate the mechanisms by which troxerutin protects cells against ultraviolet B (UVB) radiation. Methods: First, we demonstrate that pre-treatment with troxerutin protects normal human dermal fibroblasts (nHDFs) against UVB-induced cytotoxicity. Subsequently, we analyzed microRNA (miRNA) expression profiles in the nHDFs. Results: Troxerutin increased cell migra¬tion and DNA repair activity in the nHDFs. In UVB-exposed cells, miRNAs act on crucial functions, such as apoptosis and cellular senescence. miRNA expression is significantly altered during the protective process induced by phytochemicals. Conclusion: In this study, our findings indicate that pre-treatment with troxerutin increases the viability of UVB-exposed nHDFs through the alteration of the miRNA expression profiles.