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Yu, Tao,Yang, Yanyan,Kwak, Yi-Seong,Song, Gwan Gyu,Kim, Mi-Yeon,Rhee, Man Hee,Cho, Jae Youl The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.2
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis $factor-{\alpha}/interferon-{\gamma}-treated$ synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$. G-Rc also markedly suppressed the activation of TANK-binding kinase $1/I{\kappa}B$ kinase ${\varepsilon}/interferon$ regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase $1/I{\kappa}B$ kinase ${\varepsilon}/interferon$ regulatory factor-3 and p38/ATF-2 signaling.
Resveratrol Induces Apoptosis of KB Human Oral Cancer Cells
( Seong Hoon Kim ),( Heung Joong Kim ),( Myoung Hwa Lee ),( Sun Kyoung Yu ),( Chun Sung Kim ),( Joong Ki Kook ),( Hong Sung Chun ),( Eu Teum Park ),( Sook Young Lee ),( Su Gwan Kim ),( Hye Ryun Kim ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.6
Resveratrol (trans-3,4`,5,-trihydroxystilbene), a phytoalexin present in grape skin and red wine, suppresses many types of cancers by regulating cell proliferation and apoptosis through a variety of mechanisms. However, the effects of resveratrol on oral cancer are not completely understood. Thus, effects of resveratrol on cell growth and apoptosis induction were examined by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DNA fragmentation, immunoblotting, and determination of caspase activation in KB human oral cancer cells. Treatment with resveratrol induced inhibition of cell growth depending on the resveratrol treatment time and concentration in KB cells. Treatment with resveratrol induced DNA ladder formation in KB cells and promoted proteolytic cleavage of procaspase-3 and procaspase-7 with increases in the amount of cleaved caspases-3 and -7. Proteolytic processing of caspase-9 in KB cells was increased by resveratrol treatment. Activation of caspase-3/-7 was detected in living KB cells by fluorescence microscopy. These results suggest that the resveratrol can suppress cell growth and induce cell apoptosis in KB human oral cancer cells, and may have potential as an anti-cancer drug.
Resveratrol Induces Apoptosis of KB Human Oral Cancer Cells
Kim, Seong-Hoon,Kim, Heung-Joong,Lee, Myoung-Hwa,Yu, Sun-Kyoung,Kim, Chun-Sung,Kook, Joong-Ki,Chun, Hong-Sung,Park, Eu-Teum,Lee, Sook-Young,Kim, Su-Gwan,Kim, Hye-Ryun,Kim, Do-Kyung The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.6
Resveratrol (trans-3,4',5,-trihydroxystilbene), a phytoalexin present in grape skin and red wine, suppresses many types of cancers by regulating cell proliferation and apoptosis through a variety of mechanisms. However, the effects of resveratrol on oral cancer are not completely understood. Thus, effects of resveratrol on cell growth and apoptosis induction were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DNA fragmentation, immunoblotting, and determination of caspase activation in KB human oral cancer cells. Treatment with resveratrol induced inhibition of cell growth depending on the resveratrol treatment time and concentration in KB cells. Treatment with resveratrol induced DNA ladder formation in KB cells and promoted proteolytic cleavage of procaspase-3 and procaspase-7 with increases in the amount of cleaved caspases-3 and -7. Proteolytic processing of caspase-9 in KB cells was increased by resveratrol treatment. Activation of caspase-3/-7 was detected in living KB cells by fluorescence microscopy. These results suggest that the resveratrol can suppress cell growth and induce cell apoptosis in KB human oral cancer cells, and may have potential as an anti-cancer drug.
분산 네트워크 환경에서 POI추출을 위한 GPS 데이터 분할 방법
오주성 ( Joo-seong Oh ),허유경 ( Yu-kyung Heo ),박진관 ( Jin-gwan Park ),백종상 ( Jong-sang Back ),정민아 ( Min-a Jung ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
많은 사람들이 위치 기반 서비스를 사용하면서 위치 기반 서비스에서 사용되는 GPS 데이터는 기하급 수적으로 중가하고 있다. 사용자들에게 필요한 정보를 제공하기위해서는 이러한 대량의 GPS 데이터를 처리하여 POI를 추출하고 분석하는 과정이 필요하다. 본 논문에서는 POI를 추출하고 관리 • 분석하기 위해 MapReduce 환경을 구축하고 DBSCAN 클러스터링 방법을 이용한다. 또한 분산 환경 에서 DBSCAN 알고리즘을 수행하기 위해 K-Means를 이용한 데이터 분할 방법을 제안한다.