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축소 모형을 활용한 선수 규칙파 중 수륙양용장갑차의 내항 성능 평가
허영민(Youngmin Heo),전명준(Myungjun Jeon),윤현규(Hyeon Kyu Yoon) 대한조선학회 2024 大韓造船學會 論文集 Vol.61 No.2
In the present study, seakeeping performance for an amphibious vehicle in regular head waves was analyzed and evaluated experimentally and numerically. First, seakeeping tests were performed to confirm the vehicle’s motion response of heave, pitch motion and vertical acceleration in restricted wavelength ratio conditions for a simplified vehicle shape. Numerical analyses were also conducted for a simplified vehicle shape to validate the numerical solver. To simulate the vehicle’s motions, multi-degrees of freedom were calculated by a dynamic fluid-body interaction solver in STAR-CCM+. Comparison between numerical and experimental results was carried out for a simplified vehicle shape. Numerical results are in good agreement with experimental results. Second, numerical analyses were performed for a detailed vehicle shape considering seaway wavelength conditions. The seakeeping performance for an amphibious vehicle was evaluated by comparing with the existing ship’s seakeeping performance standards.
Whang, Dong Ryeol,You, Youngmin,Chae, Weon-Sik,Heo, Jeongyun,Kim, Sehoon,Park, Soo Young American Chemical Society 2012 Langmuir Vol.28 No.44
<P>In this study, we have demonstrated the reconstruction of encrypted information by employing photoluminescence spectra and lifetimes of a phosphorescent Ir(III) complex (IrHBT). IrHBT was constructed on the basis of a heteroleptic structure comprising a fluorescent N<SUP>∧</SUP>O ancillary ligand. From the viewpoint of information security, the transformation of the Ir(III) complex between phosphorescent and fluorescent states can be encoded with chemical/photoirradiation methods. Thin polymer films (poly(methylmethacrylate), PMMA) doped with IrHBT display long-lived emission typical of phosphorescence (λ<SUB>max</SUB> = 586 nm, τ<SUB>obs</SUB> = 2.90 μs). Meanwhile, exposure to HCl vapor switches the emission to fluorescence (λ<SUB>max</SUB> = 514 nm, τ<SUB>obs</SUB> = 1.53 ns) with drastic changes in both the photoluminescence color and lifetime. Security printing on paper impregnated with IrHBT or on a PMMA film containing IrHBT and photoacid generator (triphenylsulfonium triflate) enables the bimodal readout of photoluminescence color and lifetime.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2012/langd5.2012.28.issue-44/la3032013/production/images/medium/la-2012-032013_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la3032013'>ACS Electronic Supporting Info</A></P>
Han YoungHoon,Song YoungMin,Kim Geun Woo,Ha ChangSu,Lee JiSun,Kim MinHee,Son HyeYoung,Lee GiYong,Gautam Ravi,Heo Yong 한국독성학회 2021 Toxicological Research Vol.37 No.4
Microplastics (MPs) have been recently recognized as a global environmental threat and its exposure as a risk factor to human health. Health effects through MPs exposure have been recently reported, especially through oral route of exposure. Since MPs could be exposed to humans through routes other than oral, this study was designed to evaluate whether MPs exposed through the inhalation route could be delivered to fetal mice and exhibit systemic toxicity. Polyethylene (PE) with 10–45 μm diameter were administered at 0 (distilled water, vehicle control), 6 (low administration), and 60 (high administration) μg/ mouse/day to 3 pregnant dams per group from gestational day 9 to postnatal day (PND) 7 through intratracheal instillation. Dams and neonates were sacrificed at PND 7 and blood was collected. Various neonatal organs including brain, lung, heart, stomach, intestine, kidneys, and ovaries were collected for histopathological observation and weight measurement. No influence of PE-MPs administration was observed on the number of offsprings born, but the body and organs’ weight were heavier overall in the high administration group of dams and neonates than the other groups with statistical significance achieved in the heart and spleen weight. Level of serum acetylcholinesterase and glutathione peroxidase activity was decreased in the high administration group of dams and neonates compared with the other groups. Lung was the organ with highest number of PE-MPs present in the both administration groups of dams, and PE-MPs were also detected in liver and intestine of the high administration dams. Whereas, PND7 neonates showed accountable numbers of PE-MPs only in kidneys of the high administration group. Overall, the present study indicates that PE-MPs instilled intratracheally could be delivered to neonates from dams. Even though adverse effects from PE-MPs exposure during pregnant and lactational period are less prominent on both dam and neonate, potential of second-generation toxicity could be considered for further investigation.
Effects of cooking methods on the β-carotene levels of selected plant food materials
Shin, Jung-Ah,Heo, Yoonji,Seo, Mimi,Choi, Youngmin,Lee, Ki-Teak Korean Society of Food Science and Technology 2016 Food Science and Biotechnology Vol.25 No.4
In the present study, the ${\beta}-carotene$ contents of 14 plant food materials prepared by boiling, steaming, or baking or when they are raw were analyzed and compared. After boiling three pulse species, namely, peas, kidney beans, and dried mung beans, ${\beta}-carotene$ contents of peas and kidney beans increased significantly, whereas that of mung beans (dried material) decreased. True retention factors of ${\beta}-carotene$ contents in the cooked kidney beans, peas, and mung beans after boiling were 174.2, 128.3, and 91.8%, respectively. After steaming, the ${\beta}-carotene$ content of regular millets significantly decreased but that of taros increased, in which the true retention factors were observed with ${\beta}-carotene$ contents of 72.4% in the steamed regular millets and 160.9% in the steamed taros. Moreover, ${\beta}-carotene$ contents in yellow-fleshed sweet potato (raw: $896.2{\mu}g/100g$) decreased by baking ($786.4{\mu}g/100g$) and steaming (steaming: $553.1{\mu}g/100g$). These results suggest that ${\beta}-carotene$ contents in the selected plant food materials markedly depend on the cooking method and plant food materials classification.
Jang, Jin-Young,Han, Youngmin,Lee, Hongeun,Kim, Sun-Whe,Kwon, Wooil,Lee, Kyung-Hun,Oh, Do-Youn,Chie, Eui Kyu,Lee, Jeong Min,Heo, Jin Seok,Park, Joon Oh,Lim, Do Hoon,Kim, Seong Hyun,Park, Sang Jae,Lee, Wolters Kluwer Health, Inc. All rights reserved. 2018 Annals of surgery Vol.268 No.2
OBJECTIVE:: This study was performed to determine whether neoadjuvant treatment increases survival in patients with BRPC. SUMMARY BACKGROUND DATA:: Despite many promising retrospective data on the effect of neoadjuvant treatment for borderline resectable pancreatic cancer (BRPC), no high-level evidence exists to support the role of such treatment. METHODS:: This phase 2/3 multicenter randomized controlled trial was designed to enroll 110 patients with BRPC who were randomly assigned to gemcitabine-based neoadjuvant chemoradiation treatment (54 Gray external beam radiation) followed by surgery or upfront surgery followed by chemoradiation treatment from four large-volume centers in Korea. The primary endpoint was the 2-year survival rate (2-YSR). Interim analysis was planned at the time of 50% case enrollment. RESULTS:: After excluding the patients who withdrew consent (n = 8) from the 58 enrolled patients, 27 patients were allocated to neoadjuvant treatment and 23 to upfront surgery groups. The overall 2-YSR was 34.0% with a median survival of 16 months. In the intention-to-treat analysis, the 2-YSR and median survival were significantly better in the neoadjuvant chemoradiation than the upfront surgery group [40.7%, 21 months vs 26.1%, 12 months, hazard ratio 1.495 (95% confidence interval 0.66–3.36), P = 0.028]. R0 resection rate was also significantly higher in the neoadjuvant chemoradiation group than upfront surgery (n = 14, 51.8% vs n = 6, 26.1%, P = 0.004). The safety monitoring committee decided on early termination of the study on the basis of the statistical significance of neoadjuvant treatment efficacy. CONCLUSION:: This is the first prospective randomized controlled trial on the oncological benefits of neoadjuvant treatment in BRPC. Compared to upfront surgery, neoadjuvant chemoradiation provides oncological benefits in patients with BRPC.
실험동물 랫드를 이용한 미세먼지 기도노출에 따른 호흡기계 독성에 대한 마늘의 예방효과 탐색
이윤범(YoonBum Lee),김근우(GeunWoo Kim),송영민(YoungMin Song),한영훈(YoungHoon Han),하창수(ChangSu Ha),이지선(JiSun Lee),김민희(MinHee Kim),손혜영(HyeYoung Son),이기용(GiYong Lee),허 용(Yong Heo),김창열(ChangYul Kim) 한국환경보건학회 2020 한국환경보건학회지 Vol.46 No.6
Objectives: Exposure to fine dust (PM10) could contribute to the occurrence of cardiovascular disease or respiratory abnormalities. Since garlic is known to possess an anti-oxidative stress effect, the present study was performed to evaluate the effect of garlic intake on fine dust-mediated pulmonary toxicity. Methods: Rats were intratracheally instilled with fine dust at 15 mg/kg body weight (BW)/day for five days following five-day intragastric intubation of garlic at 0.7 or 1.4 g/kgBW/day, or 13.1 mg/kgBW/day S-allyl-cysteine (SAC) as a reference component in garlic. Blood and bronchoalveolar lavage fluid (BALF) were collected. Results: Deposit of fine dust was visually and histopathologically observed in the lungs. Body weight gain during the instillation period was significantly lowered in all the groups instilled with fine dust. Neutrophil numbers in blood were significantly elevated in the fine dust alone group, but this alteration was diminished in the groups administered with garlic. Levels of serum glutathione were lower in the rats instilled with fine dust alone, and this decrease in the glutathione level seems dose-dependently compensated among the groups administered with garlic. Similar findings were observed in the BALF with statistical significance. Typical pulmonary histopathological observation related with inflammation was demonstrated in the lungs of the rats exposed to fine dust alone, whereas such histopathologic findings were not improved in the groups administered with garlic. Conclusion: The present study suggests that garlic intake could alleviate fine dust-mediated pulmonary or systemic toxicities. Further investigation is necessary to delineate the mechanism of garlic-mediated effects on pulmonary function.
Multi-biomarker panel prediction model for diagnosis of pancreatic cancer
Doo-Ho LEE,Woongchang YOON,Areum LEE,Youngmin HAN,Yoonhyeong BYUN,Jae Seung KANG,Hongbeom KIM,Wooil KWON,Young-Ah SUH,Yonghwan CHOI,Junghyun NAMKUNG,Sangjo HAN,Sung Gon YI,Jin Seok HEO,In Woong HAN,Jo 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-