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Kim, Min-Ji,Bae, Soo Han,Ryu, Jae-Chan,Kwon, Younghee,Oh, Ji-Hwan,Kwon, Jeongho,Moon, Jong-Seok,Kim, Kyubo,Miyawaki, Atsushi,Lee, Min Goo,Shin, Jaekyoon,Kim, Young Sam,Kim, Chang-Hoon,Ryter, Stefan W. Informa UK (TaylorFrancis) 2016 AUTOPHAGY Vol.12 No.8
<P>Proper regulation of mitophagy for mitochondrial homeostasis is important in various inflammatory diseases. However, the precise mechanisms by which mitophagy is activated to regulate inflammatory responses remain largely unknown. The NLRP3 (NLR family, pyrin domain containing 3) inflammasome serves as a platform that triggers the activation of CASP1 (caspase 1) and secretion of proinflammatory cytokines. Here, we demonstrate that SESN2 (sestrin 2), known as stress-inducible protein, suppresses prolonged NLRP3 inflammasome activation by clearance of damaged mitochondria through inducing mitophagy in macrophages. SESN2 plays a dual role in inducing mitophagy in response to inflammasome activation. First, SESN2 induces mitochondrial priming by marking mitochondria for recognition by the autophagic machinery. For mitochondrial preparing, SESN2 facilitates the perinuclear-clustering of mitochondria by mediating aggregation of SQSTM1 (sequestosome 1) and its binding to lysine 63 (Lys63)-linked ubiquitins on the mitochondrial surface. Second, SESN2 activates the specific autophagic machinery for degradation of primed mitochondria via an increase of ULK1 (unc-51 like kinase 1) protein levels. Moreover, increased SESN2 expression by extended LPS (lipopolysaccharide) stimulation is mediated by NOS2 (nitric oxide synthase 2, inducible)-mediated NO (nitric oxide) in macrophages. Thus, Sesn2-deficient mice displayed defective mitophagy, which resulted in hyperactivation of inflammasomes and increased mortality in 2 different sepsis models. Our findings define a unique regulatory mechanism of mitophagy activation for immunological homeostasis that protects the host from sepsis.</P>
Observation of repeating microearthquake cluster near Gwangyang city, South Korea
Min-Seong Seo,YoungHee Kim,Won-Young Kim 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
Repeating earthquakes (REs) are events that occur at nearly the same location and are interpreted as the repetitive rupture of single asperity embedded within the fault. Their quasi-periodic nature in the interplate environment is frequently utilized to infer the aseismic slip rate in the neighborhood of asperity. On the other hand, intraplate REs have been rarely documented and their occurrence mechanism is still unclear. In this study, we relocated six microearthquakes with ML of 1.1 – 2.2, which took place in localized region 7 km north–northeast to the city of Gwangyang, South Korea. The first event occurred on July 20, 2021, and after 38 days of quiescence, five events occurred within two days (August 27 and 28, 2021) in the region, including the largest event (ML 2.2). By jointly exploiting manually picked P and S arrival times and precise delay time measurement from cross–correlation, we inverted for the accurate relative location of the six earthquakes with double–difference relocation algorithm. Epicenters of the six events are well aligned in the direction parallel to the strike of one of the nodal planes determined from the focal mechanism of ML 2.2 event and span the length shorter than 200 m. In addition, focal depths of the events are quite similar (~ 14 km with the maximum difference of 100 m), and the depth estimates correspond to the lower limit of seismogenic depth in South Korea. Observed high degree of waveform similarity and the narrow spatial extent of relocated hypocenters with well-constrained bootstrap error estimates in both horizontal and vertical directions (~ 4 – 20 m and ~ 9 – 40 m, respectively) indicate that the six events are repeating (or at least near–repeating) earthquakes. Considering the relatively short interoccurrence time of the events compared to REs which occur in the creeping fault segments, we classify this sequence as the burst–type RE sequence whose driving mechanism is not well clarified. We expect our unique observation to provide insight into the origin of REs in the Stable Continental Regions (SCRs).
An Analysis of User Satisfaction of K University’s Library Service
Younghee Noh,Min-Ju Choi,Yong-Wog Choi,Sin-Won Jeong,Eun-Ji Jung,Mi-So Kang,Jin-Young Kim,Kyung-Won Lee,Sung-Jae Lee,Seon-Hye Oh,So-Yeon Park,Sung-Chul Shin,Da-Jeong Suh 건국대학교 지식콘텐츠연구소 2011 International Journal of Knowledge Content Develop Vol.1 No.1
Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer.
Kang, Min Ah,Kim, Jong-Tae,Kim, Joo Heon,Kim, Soo-Young,Kim, Young Ho,Yeom, Young Il,Lee, Younghee,Lee, Hee Gu Springer-Verlag 2009 Journal of cancer research and clinical oncology Vol.135 No.6
<P>CKS2 was identified as an upregulated gene in gastric cancer via our DNA microarray. This study was to verify the upregulation of CKS2 in many gastric cancer patients and to examine the CKS2-mediated cellular response.</P>
황산 처리를 통해 개질된 TiO2 흡착제의 비소 흡착 특성에 관한 연구
장영희(Younghee Jang),정현수(Hyeonsu Jeong),김준오(Jun Oh Kim),이예환(Ye Hwan Lee),최승원(Seungwon Choi),변성제(Seongje Byun),고영서(Youngseo Go),정연호(Yeon Ho Jung),정민교(Min Kyo Jeong),이상문(Sang Moon Lee),김성수(Sung 유기성자원학회 2022 유기성자원학회 학술발표대회논문집 Vol.2022 No.추계
비소는 산업폐수와 화학적 합금, 살충제, 화석연료이 연소, 채광 작업 등 다양한 경로를 통해자연과 인간에게 노출되고 있다. 특히 먹는물로 취급되는 지하수에도 광산 등에서 용출된 비소가 포함되어 인간에게 만성적인 질병을 일으키는 독성 중금속으로 알려져 있다. 이러한 비소를 제거하기위해 상수도, 우물, 정수기 등에 흡착제를 적용하여 중금속을 제거하곤 한다. 흡착법은 다양한 가스상오염물질 제거 기술 중 운전비가 저렴하며 대부분의 물질 저감이 가능하다. 특히 잔류 독성 물질이포함되어 있는 수처리 분야에서 비용을 저감할 수 있는 해결책으로써 제시되고 있다. 본 연구에서는TiO2의 황산처리를 통해 두가지의 sulfated-TiO2를 제조하여 비소 흡착 성능을 확인하였다. 제조된흡착제는 TEM, XRD, XPS 및 FTIR 분석을 통해 물리화학적 특성을 확인하였고, 흡착제 표면의 황산종과 비소는 SO4 2-그룹에 의해 결합됨을 확인하였다. 특히, 전자 밀도를 조절하여 TiO2의 표면 산성도를 조절하고, 비소의 흡착 성능을 증진시킬 수 있는 흡착소재 제조 방법을 최적화하였다. 본 연구를 통해 개발된 흡착제로 기존 비소 흡착제 대비 20% 이상 성능을 증진시킨 소재를 제안할 수 있다.