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갑상샘 유두암을 닮은 전이성 흑색종의 세침 흡인 세포 소견 -1예 보고-
홍영옥,서재희,차희정,최혜정,김영민,Hong, Young-Ok,Suh, Jae-Hee,Cha, Hee-Jeong,Choi, Hye-Jeong,Kim, Young-Min The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2
Metastasis to the thyroid gland is very rare in clinical practice. We recently encountered a 65-year-old woman who presented with a large thyroid nodule that mimicked the cytologic features of a papillary thyroid carcinoma on fine needle aspiration biopsy (FNAB). Although initially diagnosed as a papillary thyroid carcinoma, a thorough clinical work-up revealed multiple lesions in the bones, liver, and nasal cavity, which were confirmed as metastases of a malignant melanoma. Despite a thorough physical examination, however, the primary skin lesion could not be identified. Although FNAB shows a high degree of accuracy in diagnosing primary thyroid tumors, it is less accurate in diagnosing metastases to the thyroid gland. A thorough clinical history with appropriate immunohistochemical staining assays is necessary for the accurate diagnosis of metastatic malignant melanoma.
크론병 환자에서 임신 초기 Infliximab 투여 후 정상 분만한
장영우 ( Young Woo Jang ),박영숙 ( Young Sook Park ),김성환 ( Seong Hwan Kim ),조윤주 ( Yun Ju Jo ),조영관 ( Young Kwan Jo ),안상봉 ( Sang Bong Ahn ),서용수 ( Yong Soo Seo ),홍영옥 ( Young Ok Hong ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.1
Infliximab is a chimeric IgG1 monoclonal antibody to tumor necrosis factor (TNF)-α used in the treatment of steroid refractory or dependent Crohn`s disease (CD). Patients with active CD are more likely to experience stillbirth, preterm labor, or small for gestational aged babies. The safety of administering infliximab in pregnant patients is not well documented. A 25-year-old woman, who was diagnosed with small bowel CD three years ago, was admitted to our hospital due to the aggravation of abdominal pain. She had been treated with mesalazine, azathioprine and intermittent steroid for three years. After admission, she did not respond to steroid therapy, we decided to try infliximab. After the administration of infliximab, epigastric pain was relived and Crohn`s disease activity index score decreased significantly. However after the fourth infusion of infliximab, the patient became aware that she was ten gestational weeks old pregnancy state After then, infliximab was stopped and maintained by mesalazine. The patient gave birth to a healthy baby via normal vaginal delivery without the recurrence of CD. This case suggests that infliximab administration is safe during the early period of pregnancy. Thus, we report this case with a review of literature. (Korean J Gastroenterol 2013;61:37-41)