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유봉환,김광래,사승윤,김영일 한국공작기계학회 1996 한국생산제조학회지 Vol.5 No.2
Basically, the idea underlying most edge-detection technique is the computation of a local derivative operator used for edge detection in gray level image. This concept can be easily illustrated with the aid of object which shows an image of a simple light on a dark background. Using the gray level profile along a horizontal scan line of the image, the first and second derivatives of it were acquired. This study is to develop an automatic measuring system based on the digital image processing which can be applied to the real time measurement of he characteristics of the ultra-thin thickness. The experimental results indicate tat the developed automatic inspection can be applied in real situation.
Sa, Young Jin,Seo, Dong-Jun,Woo, Jinwoo,Lim, Jung Tae,Cheon, Jae Yeong,Yang, Seung Yong,Lee, Jae Myeong,Kang, Dongwoo,Shin, Tae Joo,Shin, Hyeon Suk,Jeong, Hu Young,Kim, Chul Sung,Kim, Min Gyu,Kim, Tae American Chemical Society 2016 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.138 No.45
<P>Iron-nitrogen on carbon (Fe-N/C) catalysts have emerged as promising nonprecious metal catalysts (NPMCs) for oxygen reduction reaction (ORR) in energy conversion and storage devices. It has been widely suggested that an active site structure for Fe-N/C catalysts contains Fe-N-x coordination. However, the preparation of high-performance Fe-N/C catalysts mostly involves a high-temperature pyrolysis step, which generates not only catalytically active Fe-N-x sites, but also less active large iron-based particles. Herein, we report a general 'silica-protective-layer-assisted' approach that can preferentially generate the catalytically active Fe-N-x sites in Fe-N/C catalysts while suppressing the formation of large Fe-based particles. The catalyst preparation consisted of an adsorption of iron porphyrin precursor on carbon nanotube (CNT), silica layer overcoating, high-temperature pyrolysis, and silica layer etching, which yielded CNTs coated with thin layer of porphyrinic carbon (CNT/PC) catalysts. Temperature-controlled in situ X-ray absorption spectroscopy during the preparation of CNT/PC catalyst revealed the coordination of silica layer to stabilize the Fe-N-4 sites. The CNT/PC catalyst contained higher density of active Fe-N-x sites compared to the CNT/PC prepared without silica coating. The CNT/PC showed very high ORR activity and excellent stability in alkaline media. Importantly, an alkaline anion exchange membrane fuel cell (AEMFC) with a CNT/PC-based cathode exhibited record high current and power densities among NPMC-based AEMFCs. In addition, a CNT/PC-based cathode exhibited a high volumetric current density of 320 A cm(3) in acidic proton exchange membrane fuel cell. We further demonstrated the generality of this synthetic strategy to other carbon supports.</P>
So-Young Huh,Su-Hyun Kim,Ki Hoon Kim,Young Nam Kwon,Sung-Min Kim,Seung Woo Kim,Ha Young Shin,Yeon Hak Chung,Ju-Hong Min,Jungmin So,Young-Min Lim,Kwang-Kuk Kim,Nam-Hee Kim,Tai-Seung Nam,Sa-Yoon Kang,Je 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.6
Background and Purpose Fingolimod (FTY) inhibits lymphocyte egress from lymphoid organs to cause lymphopenia, but the clinical implications of FTY-induced lymphopenia are not fully understood. We aimed to determine the frequency and severity of lymphopenia during FTY treatment among Korean patients with multiple sclerosis (MS), and its association with infections. Methods We retrospectively reviewed the medical records of patients with MS treated using FTY from 12 referral centers in South Korea between March 2013 and June 2021. Patients were classified according to their nadir absolute lymphocyte count (ALC) during treatment: grade 1, 800–999/μL; grade 2, 500–799/μL; grade 3, 200–499/μL; and grade 4, <200/μL. Results FTY treatment was administered to 69 patients with a median duration of 18 months (range=1–169 months), with 11 patients being treated for ≥7 years. During FTY treatment, mean ALCs were reduced after the first month (653.0±268.9/μL, mean±standard deviation) (p<0.0001) and remained low during treatment lasting up to 84 months. During follow-up, 41 (59.4%) and 7 (10.1%) patients developed grade-3 and grade-4 lymphopenia, respectively. No significant difference was found in age at FTY initiation, sex, baseline ALC, body mass index, or prior disease-modifying treatment between patients with and without grade-4 lymphopenia. Infections were observed in 11 (15.9%) patients, and the frequencies of patients with and without grade-4 lymphopenia were similar. Conclusions FTY treatment induced grade-4 lymphopenia in 10% of South Korean patients with MS, but did not appear to be associated with an increased infection risk.
대장균에서 Selenocysteine을 가지고 있는 Formate Dehydrogenase H의 최적화 생산
사영승(Young Seung Sa),김용환(Yong Hwan Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.3
Much interest has been recently focused on the production of large quantities of hydrogen, due to its potential importance in our economy and needs in the petroleum and chemical industries. Formate dehydrogenase H (FDH-H) from Escherichia coli containing selenocysteine that oxidizes formate to carbon dioxide with the release of hydrogen is a component of the anaerobic formate hydrogen-lyase complex of E. coli. To make full use of FDH-H, we need effective expression condition. In this approach, we investigated the effect of pH on FDH-H stability and observed the effect of selenite and formate concentration on the activity of FDH-H. Additionally, coexpression of selenocysteine insertion genes were tried to improve the expression of FDH-H. The highest level of FDH-H expression was achieved by coexpression of selenocysteine insertion genes (pSUABC) as well as by the addition of 10 μM selenite and 10 mM formate. At this optimized condition, a 2.6 fold elevation of expression of FDH-H was achieved.
Jung, Tae-Young,Jung, Shin,Ryu, Han-Seung,Kim, In-Young,Jang, Woo-Youl,Moon, Kyung-Sub,Lim, Sa-Hoe,Kim, Dong-Yeon,Kang, Sae-Ryung,Min, Jung-Joon,Bom, Hee-Seung,Kim, Seul-Kee,Kwon, Seong Young S. Karger AG 2019 Stereotactic and functional neurosurgery Vol.97 No.4
<P><B><I>Background:</I></B> Although <sup>11</sup>C-methionine positron emission tomography (MET-PET) images can be fused with magnetic resonance (MR) images using planning software for gamma knife radiosurgery (GKR), the stereotactic information has limited value in patients with recurrent malignant brain tumor due to the difference in imaging protocols between MET-PET and MR images. The aim of this study was to evaluate the clinical application of MR imaging (MRI)-deformed MET-PET images in GKR using a deformable registration tool. <B><I>Methods:</I></B> We examined the enhanced MR stereotactic images, MET-PET and MRI-deformed MET-PET images without stereotactic information for 12 newly developed metastatic brain tumors. MET-PET and MRI-deformed MET-PET images were co-registered with the MR stereotactic images using radiosurgery planning software. Visual analysis was performed to determine whether the MET-PET and MR images matched better after using the deformable registration tool. In addition, the matching volume between MR and MET-PET images was compared before and after applying this tool. The matching volume was calculated as the metabolic tumor volume on the MET-PET images, including the MR-enhanced volume. The matching percentage was calculated as the matching volume divided by the MR-enhanced volume, multiplied by 100. <B><I>Results:</I></B> Visual analysis revealed that the MRI-deformed MET-PET images provided the same axial plane as that of the MR images, with the same window level, enabling easy identification of the tumor with the radiosurgery planning software. The mean matching percentage of the MET-PET/MR fusion images was 61.1% (range 24.7-94.7) and that of the MRI-deformed MET-PET/MR fusion images was 63.4% (range 20.8-94.3). No significant difference was found in the matching percentage between the two types of fusion images (<I>p</I> = 0.754). <B><I>Conclusions:</I></B> The MRI-deformed MET-PET images enable utilization of the functional information when planning a treatment in GKR without significant volume change.</P>
조영진(Cho, Young-Jin),남정우(Nam, Jung-Woo),배승철(Bae, Seung-Chul),사승훈(Sa, Seung-Hun),최창호(Choi, Chang-Ho),서영일(Seo, Young-Il),송재용(Song, Jae-Young),김진표(Kim, Jin-Pyo) 한국화재소방학회 2012 한국화재소방학회 학술대회 논문집 Vol.2012 No.춘계
국내의 설탕 제조공장에서 발생한 설탕 분진 폭발사고와 관련하여 조사내용을 토대로 분진폭발 원인을 분석하였다. 폭발이 발생한 장소는 제조된 설탕을 저장하는 사이로(Silo) 등이 포함되는 공간으로 설탕 분진이 항상 존재하는 곳이며, 작은 불씨만 있어도 쉽게 폭발로 이어질 수 있는 위험한 장소임을 공장 관계자들은 숙지하고 있었다. 폭발직전 용접작업이 있었음을 현장조사에서 확인할 수 있었으며, 설탕 분진이 폭발할 수 있다는 위험성에 대하여 전혀 알지 못하는 임시 직원이 작업과정에서 용접을 한 것으로 확인되었다. 분진 폭발의 위험성이 존재하는 환경에서 불꽃을 취급한 작업 자체도 부적절했지만, 안전관리 측면에서 설탕 분진의 위험성에 대하여 무지한 임시 직원이 혼자 작업할 수 있도록 용인한 점과 사전에 안전교육이 전혀 없었다는 점이 더욱 문제라고 할 수 있다.