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등영건,高春明,金聖光,孫瑀鍾,崔大卿 최신의학사 1974 最新醫學 Vol.17 No.4
The purpose of present study is to determine the toxicity of several mycotoxin-producing fungi, named A. flavus ATCC 15517, A. parasiticus RIB 1037, A. toxicarium RIB 4002, P. citrinum SWU 238, P. islandicum IFO 5235, P. tardum IFO 5787, and P. brunneum by observing the ultrastructural changes in the mouse liver cells. The results as follows: 1. All of the experimental animals treated with reference strains were observed the focal necrosis and inflammatory infiltration of liver parenchymal cell. 2. It showed cytoplamic changes such as dilatation of endoplasmic reticulum, swelling of mitochondria, detachment of ribosomes, increased number of lipid droplets and glycogens. 3. Nuclear and nucleolar alterations were also noted the nucleolar capping, segregation of nucleolar elements and irregularity of nuclear envelopes.
Polyvinylpyrrolidone-Iodine 處理에 依한 數種菌類의 微細構造 變化
勝永健 中央醫學社 1977 中央醫學 Vol.32 No.6
It has been studied that fine structural changes of several microorganisms (Escherichia coli, Neisseria gonorrhoeae, Staphylococcus aureus, Candida albicans, Cryptococcus neoformans) treated with Polyvinylpyrrolidoneodine. The alterations observed as follows: 1. It was observed that change of nucleoid, aggregation of ribosomal particles and other cytoplasmic alterations in E. coli, N. gonorrhoeae, S. aureus which were accompanied by marked breakdown of cell membrane and cell wall. 2. Particularly capsules of S. aureus was collapsed by polyvinylpyrrolidoneIodine. 3. Ultrastructural changes of above mentioned was also appeared that the more marked changes as the exposure time are longer. 4. The intra-cytoplasmic membrane systems in the cytoplasm which can observed in the control group of C. albicans and C. neoformans were disappeared because they were effected extensively by drug. The electron transparent area of cells was increased in the longer exposure group and their cell membrane, cell wall and capsule were occurred marked changes. 5. In this experiment it was considered that treatment of polyvinylpyrrolidone Iodine on several microorganisms occurred responsible cellular changes.
抗生劑( Siccanin 및 Azalomycin-F )處理에 依한 Candida albicans의 電子顯微鏡的 觀察 : Siccanin and Azalomycin-F
高春明,崔泰周,등永健 최신의학사 1973 最新醫學 Vol.16 No.6
The present study is an ultrafine structure of Candida albicans treated with Siccanin and Azalomycin F by means of electron microscopy. The results as follows: 1. In contrast to the bacteria, the normal Candida albicans contains nuclear envelop, mitochondria, endoplasmic reticulum, distinct cell wall, cell membrane and nucleus as observed in the eucaryotic cells. 2. Treated Candida albicans with Siccanin and Azalomycin-F was changed their morphology and cytoplasmic components, for examples, thicking of cell wall, partial delation of nuclear envelop, mictochondria, detachment of cell membrane from cytoplasm and increasing of lipid particles. 3. When the cells were treated with the tested antibiotics at 10 mcg per ml. for 60 minutes, the cellular damges were most severe.
Effect of Bambusae caulis in Liquamen on Streptozocin-Induced Diabetic C57BL/6 Mice
Deung Young-Kun,Park Seung-Kyu,Jin Dan,Yang Eun-Ju,Lim Soo-Jung,Kwon Ki-Rok,Kim Dong-Heui,Lee Kyu-Jae 대한의생명과학회 2005 Biomedical Science Letters Vol.11 No.3
Bambusae caulis in Liquamen is one of the important herbal medicine produced by heating bamboo indirectly and is used for treatment of stroke, hypertension, and diabetes etc. Recently the mechanism of clinical effects on Bambusae caulis in Liquamen has been studied. This experiment was conducted to confirm the clinical effects of Bambusae caulis in Liquamen on type 1 diabetes and its related mechanism. We divided C57BL/6 mice into 3 groups and induced them to be type 1 diabetes by injection of streptozocin into peritoneum. The dosage of each group was 150 mg/kg once only, 140 mg/kg once only and 40 mg/kg for 5 days respectively. The two groups injected streptozocin for once took orally Bambusae caulis in Liquamen after the induction of diabetes, and the other one group was given Bambusae caulis in Liquamen during the diabetes inducing period. As the result, the two diabetes-induced groups showed blood glucose decreasing effect by Bambusae caulis in Liquamen on an average, but they didn't show the signiftcant differences statistically. But Bambusae caulis in Liquamen showed the anti-diabetic effect suppressing blood sugar rising trend during the diabetes inducing peried (P<0.05). The anti-oxidative effect of Bambusae caulis in Liquamen was measured with the hypoxanthine/xanthine oxidase (HX/XOD) system. The quantity of ROS was measured using DCFDA reagent indirectly. As the result, $10\%$ solution of Bambusae caulis in Liquamen showed anti-oxidative effect by scavenging $93.4\%$ superoxide as compared with control group. It is suspected that the anti-oxidative effect of Bambusae caulis in Liquamen suppressed the increase of blood glucose in the diabetes-inducing group. These results could be useful data to understand the effect of Bambusae caulis in Liquamen on type 1 diabetes and type 1 diabetes developing because ROS were closely connected with the induction and complications of diabetes.