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Case Report : Genotype-4 hepatitis E in a human after ingesting roe deer meat in South Korea
( Ja Yoon Choi ),( Jeong Mi Lee ),( Yun Won Jo ),( Hyun Ju Min ),( Hyun Jin Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hae Sun Yun ),( Yeong Sil Yoon ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3
The recent increase in the number of cases of indigenous hepatitis E virus (HEV) infection highlights the importance of identifying the transmission routes for the prevention of such infections. Presented herein is the first case of acute HEV infection after ingesting wild roe deer meat in South Korea. A 43-year-old male presented with abdominal discomfort and jaundice. He had not recently traveled abroad, but had eaten raw roe-deer meat 6-8 weeks before the presentation. On the 7th day of hospitalization the patient was diagnosed with acute viral hepatitis E. Phylogenetic analysis of his serum revealed genotype-4 HEV. This case supports the possibility of zoonotic transmission of HEV because the patient appears to have been infected with genotype-4 HEV after ingesting raw deer meat. ((Iin Mol HepatoI2013;19:309¬314)
Cellular Oxidative Stress Response to Graphene Oxide Films Functionalized by NH<sub>3</sub> Plasma
Yoon, Ok Ja,Son, Young Min,Hwang, Byeong-Ung,Sohn, Il-Yung,Lee, Nae-Eung American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.11
<P>Functionalization of graphene oxide (GO) films was performed for the enhancement of bioaffinity by NH3 plasma treatment. Our results demonstrated that the damage free treatments caused a significant change in the surface charge states from negatively charged states with oxygen containing groups on the pristine GO to positively charged states with amine groups on the functionalized GO (f-GO) films. The effects of the conversion of the surface charge states of GO on bioaffinity and biocompatibility were investigated through studies of the reactive oxygen species (ROS) generation mitochondrial morphology and cell proliferation and viability during the growth of HeLa cells on GO and f-GO films. The proliferation and viability of HeLa cells on GO and f-GO films were enhanced compared to those of the control cells. Also the ROS generation on the f-GO (20s treatment) films compared to the other films was reduced. The different physicochemical properties of f-GO induced by plasma-chemical functionalization had a decisive influence on the ROS generation and the proliferation and viability of cells.</P>
Ja Hyun Koo,Jin Pyo Hong,Chae Ok Kim,Il Jae Shin,이종현,Kap Soo Yoon,Ki Woong Kim,Young Deung Kim 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
An ultra-thin AlOx tunnel barrier was prepared to obtain high quality of magnetic tunnel junctions (MTJs) using a remote rf oxidation process. The tunnel barrier was schematically investigated as a function of mixed gas ratio with Ar and O2, and various oxidation times. Electrical breakdown voltage and magneto-resistance of MTJs were about 1.2 V and 22 %, respectively. Especially the dielectric properties of our tunnel barriers were optically analyzed by using a surface plasmon resonance spectroscopy (SPRS) to observe the oxidation state inside the barrier. The observed SPRS result exhibits that the AlOx tunnel barrier was a bulk-property of Al2O3 at optimum oxidation time of 75 s, resulting in the highest magnetoreistance.
Ok Ja Yoon(윤옥자) 한국고분자학회 2018 폴리머 Vol.42 No.6
다양한 바이오 응용에서 중요한 측정 인자인 과산화 수소(H₂O₂) 센서를 개발하기 위하여, 알지네이트(A) 용액에 수용성 프러시안 블루(s-PB), 그리고 환원된 그래핀 옥사이드(rGO)를 분산시켜 전극 소재를 만들었고 탄소 스크린 프린트 전극에 복합 용액을 젤화 과정을 통해 전극에 고정시켰다. 젤화 과정에서 전극 소재에 남아 있는 염을 제거하기 위하여 충분히 수세를 한 후 실온에서 건조하였다. 전극 소재의 특성은 푸리에 변환 적외선 (FTIR), 전계방출 주사 전자 현미경(FE-SEM)으로 조사하였다. A/s-PB/rGO 전극을 이용한 순환 전류(CV) 측정 결과를 통해 전극으로써 우수한 전기 화학 반응, 안정성, 재현성을 확인하였고, 미분 펄스 볼타 그램(DPV)으로 측정한 산화 전류는 4 mM(S/N = 3)의 검출 한계와 높은 감도(2.7 ㎂ · mM-1· ㎝-2)를 나타내었다. 전기화학적 센서 기반의 전극 개발은 의학 및 환경 응용 분야에서 매우 중요하게 활용될 것으로 판단된다. An electrochemical H₂O₂ sensor was developed using an alginate/water-soluble prussian blue/reduced graphene oxide (A/s-PB/rGO) composite on carbon screen printed electrodes for use in bioapplications. Carbon screenprinted working electrodes were modified with A/s-PB, A/rGO, and A/s-PB/rGO composite solutions by in situ gelation. The composites were characterized by Fourier transform infrared spectroscopy and field emission scanning electron microscopy. The cyclic voltammetric measurements made using the electrode modified by A/s-PB/rGOs showed improved electrochemical reaction and stability over the A/s-PB and A/rGO modified electrodes. A two-electron transfer process is indicated at the modified electrode surface. The oxidation current showed a detection limit of 4 mM (S/N = 3) and linear range of 4–28 mM. The A/s-PB/rGO modified electrode provides a tool for high-sensitivity (2.7 ㎂·mM-1·㎝-2) and stable H₂O₂ analyses with a low limit of detection. Development of biosensor-based modified electrodes is important for biomedical and environmental applications.