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Liancai Wang,Yingfeng Wu,Liang Chen,Yongquan Gu,Tingfei Xi,Aiying Zhang,Zeng-guo Feng 한국물리학회 2005 Current Applied Physics Vol.5 No.5
As initial step for developing tissue-engineered vascular autografts, a novel series of biodegradable aliphaticaromatic copoly-esters were synthesized and tubular scaolds were fabricated. Cytotoxicity, adhesion and growth of dierent kinds of cells on thepolyester lms and in vivo biocompatibility have been evaluated. The results indicate that these copolyesters possess good biocom-patibility. Canine bone marrow cells were seeded on the scaolds and cultured in a bioreactor for 3 days. A conuent, adherentmonolayer bone marrow cells was observed in the scaold lumen. All the testing results suggest that these copolyesters might ulti-mately nd applications for vascular tissue engineering..
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BMB Reports : Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage
( Chao Zhang ),( Tao Luo ),( Shijun Cui ),( Yongquan Gu ),( Chunjing Bian ),( Yibin Chen ),( Xiaochun Yu ),( Zhonggao Wang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.6
Vascular smooth muscle cells (VSMCs) undergo death during atherosclerosis, a widespread cardiovascular disease. Recent studies suggest that oxidative damage occurs in VSMCs and induces atherosclerosis. Here, we analyzed oxidative damage repair in VSMCs and found that VSMCs are hypersensitive to oxidative damage. Further analysis showed that oxidative damage repair in VSMCs is suppressed by a low level of poly (ADP-ribosyl)ation (PARylation), a key post-translational modification in oxidative damage repair. The low level of PARylation is not caused by the lack of PARP-1, the major poly(ADP-ribose) polymerase activated by oxidative damage. Instead, the expression of poly(ADP-ribose) glycohydrolase, PARG, the enzyme hydrolyzing poly(ADP-ribose), is significantly higher in VSMCs than that in the control cells. Using PARG inhibitor to suppress PARG activity facilitates oxidative damage-induced PARylation as well as DNA damage repair. Thus, our study demonstrates a novel molecular mechanism for oxidative damage-induced VSMCs death. This study also identifies the use of PARG inhibitors as a potential treatment for atherosclerosis. [BMB Reports 2015; 48(6): 354-359]
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The development of training platform for CiADS using cave automatic virtual environment
Jin-Yang Li,Jun-Liang Du,Long Gu,You-Peng Zhang,Xin Sheng,Cong Lin,Yongquan Wang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
The project of China initiative Accelerator Driven Subcritical (CiADS) system has been started to construct in southeast China's Guangdong province since 2019, which is expected to be checked and accepted in the year 2025. In order to make the students in University of Chinese Academy of Sciences (UCAS) better understand the main characteristic and the operation condition in the subcritical nuclear facility, the training platform for CiADS has been developed based on the Cave Automatic Virtual Environment (CAVE) in the Institute of Modern Physics Chinese Academy of Sciences (IMPCAS). The CAVE platform is a kind of non-head mounted virtual reality display system, which can provide the immersive experience and the alternative training platform to substitute the dangerous operation experiments with strong radioactivity. In this paper, the CAVE platform for the training scenarios in CiADS system has been presented with real-time simulation feature, where the required devices to generate the auditory and visual senses with the interactive mode have been detailed. Moreover, the three dimensional modeling database has been created for the different operation conditions, which can bring more freedom for the teachers to generate the appropriate training courses for the students. All the user-friendly features will offer a deep realistic impression to the students for the purpose of getting the required knowledge and experience without the large costs in the traditional experimental nuclear reactor.
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Yong Quan,Guo Qiang Fub,Zi Feng Huang,Ming Gu 한국풍공학회 2020 한국풍공학회지 Vol.24 No.4
The statistical characteristics of typhoon wind speed records tend to have a considerable time-varying trend; thus, the stationary wind model may not be appropriate to estimate the wind characteristics of typhoon events. Several nonstationary wind speed models have been proposed by pioneers to characterize wind characteristics more accurately, but comparative studies on the applicability of the different wind models are still lacking. In this study, three landfall typhoons, Ampil, Jongdari, and Rumbia, recorded by ultrasonic anemometers atop the Shanghai World Financial Center (SWFC), are used for the comparative analysis of stationary and nonstationary wind characteristics. The time-varying mean is extracted with the discrete wavelet transform (DWT) method, and the time-varying standard deviation is calculated by the autoregressive moving average generalized autoregressive conditional heteroscedasticity (ARMA-GARCH) model. After extracting the time-varying trend, the longitudinal wind characteristics, e.g., the probability distribution, power spectral density (PSD), turbulence integral scale, turbulence intensity, gust factor, and peak factor, are comparatively analyzed based on the stationary wind speed model, time-varying mean wind speed model and time-varying standard deviation wind speed model. The comparative analysis of the different wind models emphasizes the significance of the nonstationary considerations in typhoon events. The time-varying standard deviation model can better identify the similarities among the different typhoons and appropriately describe the nonstationary wind characteristics of the typhoons.
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Effects of vertical ribs protruding from facades on the wind loads of super high-rise buildings
Yong Quan,Fangchao Hou,Ming Gu 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.2
The auxiliary structures of a high-rise building, such as balconies, ribs, and grids, are usually much smaller than the whole building; therefore, it is difficult to simulate them on a scaled model during wind tunnel tests, and they are often ignored. However, they may have notable effects on the local or overall wind loads of the building. In the present study, a series of wind pressure wind tunnel tests and high-frequency force balance (HFFB) wind tunnel tests were conducted on rigid models of an actual super high-rise building with vertical ribs protruding from its facades. The effects of the depth and spacing of vertical ribs on the mean values, fluctuating values and the most unfavorable values of the local wind pressure coefficients were investigated by analyzing the distribution of wind pressure coefficients on the facades and the variations of the wind pressure coefficients at the cross section at 2/3 of the building height versus wind direction angle. In addition, the effects of the depth and spacing of vertical ribs on the mean values, fluctuating values and power spectra of the overall aerodynamic force coefficients were studied by analyzing the aerodynamic base moment coefficients. The results show that vertical ribs significantly decrease the most unfavorable suction coefficients in the corner recession regions and edge regions of facades and increase the mean and fluctuating along-wind overall aerodynamic forces.
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