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Wenjie Li,Chaodan Luo,Yongmei Huang,Jingting Zhan,Jinli Lei,Ning Li,Xiaoqi Huang,Hui Luo 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.4
The present work aimed to estimate the possible anti-fatigue effect and potential mechanism of Isochrysis galbana (IG) in mice. The anti-fatigue activity of IG (100, 200, and 400 mg/kg) was elucidated by a weight-loaded forced swimming test, and the potential mechanism was explored by determination of fatigue-related biochemical parameters. The results showed that pretreatment with IG significantly extended the exhaustive swimming time and increased the levels of liver glycogen, muscle glycogen and blood glucose in a dose-dependent manner. Besides, the increased levels of alanine aminotransferase, aspartate aminotransferase, blood lactic acid, lactic dehydrogenase, creatine kinase, and blood urea nitrogen by exhausted swimming, were dramatically attenuated by pretreatment with IG. Furthermore, supplementation with IG significantly enhanced the glutathione peroxidase and superoxide dismutase levels, while attenuated the level of malonaldehyde. Taken together, IG possessed appreciable efficacy to alleviate fatigue, and the mechanism might be associated with favorably modulating the process of energy consumption, metabolism, and attenuating oxidative stress injury.
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A pressure-transient model for a fractured-vuggy carbonate reservoir with large-scale cave
Peng Chen,Xinhai Wang,Hong Liu,Yongmei Huang,Hao Zhang 한국자원공학회 2016 Geosystem engineering Vol.19 No.2
In the development process of fractured-vuggy carbonate reservoir with large-scale caves, the location and size of cave affect the development program. This paper takes the large-scale cave as equipotential body, treats matrix and fracture as double porous media, and establishes the flow model. Laplace transform is used to simplify the model, and then the model is solved using boundary element method. Considering the wellbore storage effect and skin effect, the bottomhole pressure-transient curve is obtained using Stefest numerical inversion method. Comparing the results of analytical solution and boundary element method in the dual porosity medium illustrate the accuracy of this model. The sensitivity of cave parameters is analyzed. It shows that the larger the cave radius is, the stronger the convex and concave of curve is. The convex is earlier and concave is sooner when cave is closer to the well. The segment of convex keeps longer and the concave margin is greater with the larger compressibility ratio. Finally, as an application example, actual test data from a large-scale cave reservoir is analyzed using this model, and the location and size of cave are obtained. It has a certain significance for the reserve evaluation and well test in this reservoir.
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