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Yonghyun Gwon,Woochan Kim,Sunho Park,Jangho Kim 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
A bone regeneration scaffold is typically designed to effectively heal a bone defect while preventing soft tissue infiltration. Despite the wide variety of scaffold materials currently available, such as collagen, critical problems in achieving bone regeneration remain, including a rapid absorption period and low tensile strength as well as high costs. Inspired by extracellular matrix protein and topographical cues, we developed a polycaprolactone (PCL)-based scaffold for bone regeneration using a soluble eggshell membrane protein (SEP) coating and a nanotopography structure for enhancing the physical properties and bioactivity. The highly aligned nanostructures and SEP coating were found to regulate and enhance cell morphology, adhesion, proliferation, and differentiation in vitro. The scaffolds coated with SEP applied to the defect site promoted bone regeneration along the direction of the nanotopography in vivo. These findings demonstrate that bone-inspired nanostructures and SEP coatings have high potential to be applicable in the bone regeneration scaffold.
Eggshell Membrane-incorporated Cell Friendly Tough Hydrogels with Ultra-Adhesive Property
( Yonghyun Gwon ),( Sunho Park ),( Woochan Kim ),( Hyoseong Kim ),( Jangho Kim ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.1
Adhesive and tough hydrogels have received increased attention for their potential biomedical applications. However, traditional hydrogels have limited utility in tissue engineering because they tend to exhibit low biocompatibility, low adhesiveness, and poor mechanical properties. Herein, the use of the eggshell membrane (ESM) for developing tough, cell-friendly, and ultra-adhesive hydrogels is described. The ESM enhances the performance of the hydrogel network in three ways. First, its covalent cross-linking with the polyacrylamide and alginate chains strengthens the hydrogel network. Second, it provides functional groups, such as amine and carboxyl moieties, which are well known for enhancing the surface adhesion of biomaterials, thereby increasing the adhesiveness of the hydrogel. Third, it is a bioactive agent and improves cell adhesion and proliferation on the constructed scaffold. In conclusion, this study proposes the unique design of ESM-incorporated hydrogels with high toughness, cell-friendly, and ultra-adhesive properties for various biomedical engineering applications.
Eggshell Membrane-incorporated Cell Friendly Tough Hydrogels with Ultra-Adhesive Property
( Yonghyun Gwon ),( Sunho Park ),( Woochan Kim ),( Jangho Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.2
Adhesive and tough hydrogels have received increased attention for their potential biomedical applications. However, traditional hydrogels have limited utility in tissue engineering because they tend to exhibit low biocompatibility, low adhesiveness, and poor mechanical properties. Herein, the use of the eggshell membrane (ESM) for developing tough, cell-friendly, and ultra-adhesive hydrogels is described. The ESM enhances the performance of the hydrogel network in three ways. First, its covalent cross-linking with the polyacrylamide and alginate chains strengthens the hydrogel network. Second, it provides functional groups, such as amine and carboxyl moieties, which are well known for enhancing the surface adhesion of biomaterials, thereby increasing the adhesiveness of the hydrogel. Third, it is a bioactive agent and improves cell adhesion and proliferation on the constructed scaffold. In conclusion, this study proposes the unique design of ESM-incorporated hydrogels with high toughness, cell-friendly, and ultra-adhesive properties for various biomedical engineering applications.
Preparation and Characterization of Small Gelatin Nanoparticles with Stable Size Distributions
( Yonghyun Gwon ),( Sunho Park ),( Sujin Kim ),( Daun Kim ),( Ayoun Kim ),( Jangho Kim ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.2
The conventional two-step desolvation method was modified for the fabrication of small gelatin nanoparticles (GNPs). The technique was based on the natural phenomenon where with decreasing temperature, the compression between the molecules of substances increases and the volume shrinks. The average size of the fabricated small GNPs was less than 100 nm and their gelatin properties (including non-cytotoxicity) were well maintained. The drug release profiles of the GNPs were confirmed, for which a simple mathematical model based on the conventional diffusion equation was proposed. There was a burst of drug release in the first 3 days, with different release profiles according to the concentration of model drugs loaded onto the GNPs. It was also demonstrated that the drug release profiles of the proposed mathematical model were consistent with the experimental results. Our work proposes that these small GNPs could be used as efficient small material delivery platforms for various biomedical (e.g., medical drugs) and agriculture (e.g., pesticides) applications.
Nano-enabled Biosystems Engineering for Future Agriculture
( Sunho Park ),( Yonghyun Gwon ),( Woochan Kim ),( Hyoseong Kim ),( Jangho Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
Despite progress in agricultural prosperity, agriculture faces some problems such as the drop in profitability and the reduction in deforestation, necessitating development of an effective and productive agricultural system. To encourage a productive agricultural system, biosystems engineering have a important role in the impending agri-tech revolution to promote the proper regulatory arrangement. Recently, nanotechnology regards as emerged technology to support biosystems engineering for sustainable agriculture incorporating food security and human health. In this study, we proposed nano-enabled biosystems engineering for future advanced agriculture. Specifically, we reveal that nanomaterials (i.e., graphene) can promote the plant and crop growth, showing the enhanced florescence and the increased sugar content. In addition, biocompatible nanoparticles can improve the pesticide performance and plant growth without cytotoxicity. In addition, nanotopography inspired by extracellular matrix can induce the animal tissue regeneration. Using nano-enabled biosystems engineering, we can confirm their potential use for improving functions of biosystems in the near future.
Flexible and Biodegradable Nanoporous Films for Application in Active Food Packaging Systems
( Woochan Kim ),( Taeseong Han ),( Yonghyun Gwon ),( Sunho Park ),( Hyoseong Kim ),( Jangho Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
Nanotechnology has facilitated the development of active food packaging systems with functions that could not be achieved by their traditional counterparts. Such smart and active systems can improve the shelf life of perishable products and overcome major bottlenecks associated with the fabrication of safe and environmentally friendly food packaging systems. Herein, we used a plasma-enabled surface modification strategy to fabricate biodegradable and flexible nanoporous polycaprolactone-based (FNP) films for food packaging systems. Their capacity for preserving tomatoes, tangerines, and bananas at room and refrigeration temperatures was tested by analyzing various fruit parameters (mold generation, appearance changes, freshness, weight loss, firmness, and total soluble solids contents). Compared with commonly used polyethylene terephthalate-based containers, the proposed system enhanced the fruit storage quality (i.e., retained appearance, reduced weight loss, better firmness, and sugar contents) by controlling moisture evaporation and inhibiting mold generation. Thus, the FNP film represents a new active food packaging strategy.
( Woochan Kim ),( Taeseong Han ),( Yonghyun Gwon ),( Sunho Park ),( Hyoseong Kim ),( Jangho Kim ) 한국농업기계학회 2022 한국농업기계학회 학술발표논문집 Vol.27 No.1
Nanotechnology has facilitated the development of active food packaging systems with functions that could not be achieved by their traditional counterparts. Such smart and active systems can improve the shelf life of perishable products and overcome major bottlenecks associated with the fabrication of safe and environmentally friendly food packaging systems. Herein, we used a plasma-enabled surface modification strategy to fabricate biodegradable and flexible nanoporous polycaprolactone-based (FNP) films for food packaging systems. Their capacity for preserving tomatoes, tangerines, and bananas at room and refrigeration temperatures was tested by analyzing various fruit parameters (mold generation, appearance changes, freshness, weight loss, firmness, and total soluble solids contents). Compared with commonly used polyethylene terephthalate-based containers, the proposed system enhanced the fruit storage quality (i.e., retained appearance, reduced weight loss, better firmness, and sugar contents) by controlling moisture evaporation and inhibiting mold generation. Thus, the FNP film represents a new active food packaging strategy.
Woochan Kim,Sunho Park,Yonghyun Gwon,Jangho Kim 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Here, we present an analysis of nanoscale deformation of PDMS molds in response to heat and pressure during the repetitive molding process of thermoplastic polymers. The width and height of the nano-sized ridges of PDMS molds decreased as the number of replications of thermoplastic polymers increased. Using the precisely controlled deformation of nanostructures in PDMS molds, we demonstrated that nanostructures of different sizes can be fabricated on representative thermoplastic and UV-curable polymers consistently. Using the precisely tunable methodologies of nanoscale structures, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with oxygen plasma modification. In response to multiscale nanotopographic and chemically modified surface cues, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models.