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RISS 인기검색어
- 검색키워드
- 저자 : Yingjie Hong (검색결과 2 건)
- 무료
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- 유료
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Jin, Yingji,Kim, Seung Cheol,Kim, Hyoung Jin,Ju, Woong,Kim, Yun Hwan,Kim, Hong-Jin De Gruyter 2016 Clinical chemistry and laboratory medicine Vol.54 No.11
<P><B>Abstract</B></P>Background: The Pap test has been used for over 50 years for primary screening of cervical cancer. There has been no study of glycosylation changes in Pap test samples despite considerable potential of the glycosylation changes as biomarkers for detecting cancerous lesions. In this study, we developed a 96-well platform for enzyme-linked lectin assays (ELLAs) to evaluate glycosylation levels in cervical cells.Methods: A total of 117 samples of exfoliated cervical cells (ECCs) from 37 individuals with normal cytology, 20 with cervical intraepithelial neoplasia (CIN) 1, 19 with CIN 2, 26 with CIN 3 and 15 with cervical cancer were analyzed by ELLAs. The wells of 96-well plates were coated with lysates of the cervical cells, and sialylation and fucosylation levels were compared between the groups.Results: Sialylation levels increased and fucosylation levels decreased with increasing grade of cervical dysplasia. ELLAs for sialylation [ELLA-Sambucus nigra (SNAs)] and fucosylation [ELLA-Aleuria aurantia lectin (AAL)] discriminated not only CIN 2 and worse (CIN 2+: CIN 2, CIN 3, and cancer) from normal cytology but also CIN 3 and worse (CIN 3+: CIN3 and cancer) from normal cytology. ELLA-SNAs and ELLA-AALs distinguished cancer from normal cytology with a high true-positive rate (TPR) (ELLA-SNAs: 87%; ELLA-AALs: 87%) and low false-positive rate (FPR) (ELLA-SNAs: 19%; ELLA-AALs: 11%).Conclusions: The sialylation and fucosylation levels of ECCs as measured by ELLAs have great potential as biomarkers for primary screening of cervical cancer.
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Hongyan Chu,Yingjie Hong,Caixia Zhang,Qi Chen,Ruilong Ding,Congbin Yang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.7
In order to improve the printing quality, this study focused on the thermo-fluidsolid coupling process of ink roller-ink. One of the highlights of this study is to consider the influence of temperature on the rubber hyperelastic parameters, viscoelastic parameters, and ink viscosity. The other highlight is to improve the elastohydrodynamic lubrication theory and Hertz contact theory through the rubber elastic modulus, which is determined by the relaxation curve considering the temperature and working conditions. Furthermore, based on the improved theory, the thermo-fluid-solid coupling model of ink roller-ink was established. Finally, the effect of temperature on the coupling process was analyzed. The results show that under the working conditions, with increasing temperature from 20 °C to 40 °C, the contact half-width increases from 4.2335 mm to 4.4701 mm, and the minimum ink film thickness decreases from 0.5097 mm to 0.1410 mm, and the maximum ink pressure decreases from 0.6802 MPa to 0.6618 MPa.
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