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Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Ying-ying Zhang,Ru-yu Xia,Shi-bing Liang,Xiao-yang Hu,Meng-yuan Dai,Yi-lin Li,Le-yi Zhao,Michael Moore,Yu-tong Fei,Jian-ping Liu 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.3
Background: Shufeng Jiedu capsule has been widely used in China for acute upper respiratory tract infections (AURTIs). The aim of this study was to evaluate its effectiveness and safety for AURTIs. Methods: Randomized controlled trials comparing SFJD with conventional drug for patients with AURTIs were included. Eight databases were searched from their inceptions to February 2021. Data was synthesized using risk ration (RR) or mean difference (MD) with their 95% confidence interval (CI). The primary outcome was resolution time of typical symptoms. Results: Twenty-five RCTs involving 3410 patients were included. SFJD in combination with conventional drug was associated with; in common cold shortening the duration of fever (MD −1.54 days, 95% CI [−2.15,−0.92], I2 = 80%, n = 385, 3 trials) and cough (MD −1.22 days, 95% CI [−1.52, −0.93]); in herpangina, shortening the duration of fever (MD -0.68 days, 95% CI [−1.15, −0.21], I2 = 68%, n = 140, 2 trials) and blistering (MD −0.99 days, 95% CI [−1.23, −0.76], n = 386, 3 trials); in acute tonsillitis and acute pharyngitis shortening the duration of fever (MD −1.13 days, 95% CI [−1.36, −0.90], I2 = 33%, n = 688, 7 trials) and sore throat (MD −1.13 days, 95% CI [−1.40, −0.86], I2 = 84.1%, n = 1194, 10 trials). SFJD also improving their cure rate with a range (1–5 days). No serious adverse events were reported. Conclusion: Low certainty evidence suggests that SFJD appears to shorten the duration of symptoms in AURTIs, improve cure rate and seems safe for application. However, high quality placebo controlled trials are warranted to confirm its benefit.
Hu, Ying,Joung, Joonyoung F.,Jeong, Ji-Eun,Jeong, Yerin,Woo, Han Young,She, Yuanbin,Park, Sungnam,Yoon, Juyoung Elsevier 2019 Sensors and actuators. B Chemical Vol.280 No.-
<P><B>Abstract</B></P> <P>2-(Benzothiazol-2-yl)pyren-1-ol (<B>P3-NS</B>) was developed as a excited-state intramolecular proton transfer (ESIPT)- based sensor for nitroaromatic compounds (NACs). Results of studies of its photophysical and optical properties show that <B>P3-NS</B> exists in various, solvent dependent isomeric forms arising from rotation about the CC bond connecting the benzothiazole and pyren-1-ol rings and the location of the pyrene-OH proton. The results of density functional theory (DFT) calculations enabled identification of the major structures of <B>P3-NS</B> dissolved in different solvents. Upon electronic excitation in nonpolar or weakly polar solvents, <B>P3-NS</B> undergoes an ESIPT reaction to form a product that only weakly fluoresces. In contrast, <B>P3-NS</B> exists in a strongly fluorescent deprotonated form in highly polar solvents. The results of time-dependent DFT calculations indicate that fluorescence quenching of the product generated by ESIPT reaction of <B>P3-NS</B> is caused by intersystem crossing at a conical intersection between S<SUB>1</SUB> and T<SUB>2</SUB> states. The anionic form of <B>P3-NS</B>, present in highly polar solvents, was shown to be a fluorescence sensor for nitroaromatic compounds (NACs). Fluorescence quenching by NACs occurs by protonation of the anionic form of <B>P3-NS</B> (static quenching) and by photoinduced electron transfer from the anionic form to NACs (dynamic quenching).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new hydroxypyrene derivative <B>P3-NS</B> bearing benzothiazole is developed as a fluorescent sensor for nitroaromatic compounds. </LI> <LI> <B>P3-NS</B> undergoes excited-state intramolecular proton transfer reaction in nonpolar or weakly polar solvents. </LI> <LI> <B>P3-NS</B>, as a sensor, exhibits a selective strong response to picric acid over other nitroaromatic compounds. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Energy-saving Methods in the Operation of Virtual Networks Based on Divided Time Slices
HU Ying,ZHUANG Lei,HU Yu-xiang,MA Ding 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.7
Reducing energy consumption has also become an important way to reduce expenditures and increase revenue for ISP. For solving the problem of dynamically changing network-flow of virtual network in runtime, we first analyze relations and differences between virtual network and IP network on energy-saving issues. We secondly model the makeup of energy consumption in virtual network, and determine the object of energy-saving in virtual network at. Finally we propose the solutions to this energy-saving problem. The solutions can be described as follows: (1) based on the historical data of daily network-flow, we divide one day into two time slices, and one is called idle time slice, the other is called busy time slice; (2) we design the dynamic switch-off algorithm and run it at the beginning of idle time slice, and we use former algorithms to be started at the beginning of busy time slice; (3) in the dynamic switch-off algorithm we determine the method to select virtual networks and the method to remap; (4) we apply roulette wheel to select virtual networks, in the selection method we consider both current influences on energy-saving and influences in the future. Simulation results show that the dynamic switch-off algorithm can effectively select virtual networks, and the whole solution performs well in energy aware virtual network in runtime.
Migration and Energy Aware Network Traffic Prediction Method Based on LSTM in NFV Environment
Ying Hu,Liang Zhu,Jianwei Zhang,Zengyu Cai,Jihui Han 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.3
The network function virtualization (NFV) uses virtualization technology to separate software from hardware. One of the most important challenges of NFV is the resource management of virtual network functions (VNFs). According to the dynamic nature of NFV, the resource allocation of VNFs must be changed to adapt to the variations of incoming network traffic. However, the significant delay may be happened because of the reallocation of resources. In order to balance the performance between delay and quality of service, this paper firstly made a compromise between VNF migration and energy consumption. Then, the long short-term memory (LSTM) was utilized to forecast network traffic. Also, the asymmetric loss function for LSTM (LO-LSTM) was proposed to increase the predicted value to a certain extent. Finally, an experiment was conducted to evaluate the performance of LO-LSTM. The results demonstrated that the proposed LO-LSTM can not only reduce migration times, but also make the energy consumption increment within an acceptable range.
Colorimetric and Fluorescent Detecting Phosgene by a Second-Generation Chemosensor
Hu, Ying,Zhou, Xin,Jung, Hyeseung,Nam, Sang-Jip,Kim, Myung Hwa,Yoon, Juyoung American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.5
<P>Because of the current shortage of first-generation phosgene sensors, increased attention has been given to the development of fluorescent and colorimetric based methods for detecting this toxic substance. In an effort focusing on this issue, we designed the new, second-generation phosgene chemosensor <B>1</B> and demonstrated that it undergoes a ring-opening reaction with phosgene in association with color and fluorescent changes with a detection limit of 3.2 ppb. Notably, in comparison with the first-generation sensor RB-OPD, <B>1</B> not only undergoes a much faster response toward phosgene with an overall response time within 2 min, but it also generates no byproducts during the sensing process. Finally, sensor <B>1</B> embedded nanofibers were successfully fabricated and used for accurate and sensitive detection of phosgene.</P> [FIG OMISSION]</BR>