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Gel-sol/sol-gel switchable Iron(III)-succinoglycan coordination hydrogel for controlled delivery
( Hu Yiluo ),정다함,정선호 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
A kind of “switchable” hydrogel material with a particular redoxresponsive phenomena have a potential application in extensive fields. We fabricated redox-responsive hydrogel bead based on succinoglycan coordinated with ferric ion. Succinoglycan was isolated and purified from Sinorhizobium meliloti Rm 1021 and the structure of succinoglycan was analyzed by using NMR spectroscopy. We tested rheology of succinoglycan coordinated with metal solution by rheometer. Then succinoglycan coordinated with Fe(Ⅲ) ions was characterized by FT-IR and observed morphology by SEM. Succinoglycan-Fe(Ⅲ) hydrogel bead possessed gel-sol/sol-gel conversion property in redox stimuli, for instance, administration of ascorbic acid or hydrogen peroxide. According to redox-responsive phenomena, Iron(Ⅲ)-succinoglycan hydrogel encapsulated drug as a particular drug release material.
( Hu Yiluo ),정다함,( Shinde Vijay Vilas ),조은애,정선호 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
Sophorolipid is a class of microbial surfactant produced by Candida sp. Sophorolipid has antibacterial activity and β-cyclodextrin can form the inclusion complex with antibiotics. Here, we synthesis of sophorolipid- β-cyclodextrin bolaamphiphilic surfactant composed of β-cyclodextrin and sophorose connected by hexadecane. Sophorolipid-β-cyclodextrin was successfully synthesized by reacting mono-6-amino-6-deoxy-β-cyclodextrin with N-hydroxysuccinimide ester of acidic sophorolipid. Sophorolipid-β-cyclodextrin was characterized by NMR, FT-IR and MALDI-TOF MS spectroscopy analysis. We also investigated the antibacterial activities of sophorolipid-β-cyclodextrin for E. coil and S. aureus.
1P-176 Synthesis and bolaamphiphilic property of sophorolipid-β-cyclodextrin conjugate
( Hu Yiluo ),박경희,조은애,정선호 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
A novel bolaamphiphilic surfactant composed of β-cyclodextrin and sophorose connected by hexadecane was successfully synthesized by reacting mono-6-amino-6-deoxy-β-cyclodextrin with N-hydroxysuccinimide ester of acidic sophorolipid. Sophorolipid was produced by Candida bombicola fermentation on glucose with hexadecane, and the acidic form was prepared by alkaline hydrolysis. Based on the dualstructure of well-known biosurfactant sophorolipid and host β-cyclodextrin, it has potential for various application in biomedical, cosmetic and environmental field.
Carboxymethyl cyclosophoraoses as a flexible pH-responsive solubilizer for pindolol
Hu, Yiluo,Kim, Hwanhee,Shinde, Vijay Vilas,Jeong, Daham,Choi, Youngjin,Cho, Eunae,Jung, Seunho Elsevier 2017 Carbohydrate polymers Vol.175 No.-
<P><B>Abstract</B></P> <P>In the present study, cyclosophoraoses (CyS) (β-1,2 linked cyclic glucans, with glucopyranose units ranging from 17 to 23) isolated from <I>Rhizobium leguminosarum</I> biovar <I>viciae</I> VF-39 were modified with carboxymethyl (CM) groups, and the pH-sensitive complexation of CM CyS with pindolol was investigated. The solubility of pindolol increased 32-fold by its complexation with 5mM CM CyS at pH 10, whereas it shows no significant change at pH 3. Pindolol, a β-adrenergic blocking agent, has a hydrophobic nature at non-ionized state, and CM CyS could solubilize efficiently pindolol in a high alkaline solution. The carboxymethylation of flexible CyS allows them to present a more suitable cavity for the hydrophobic pindolol at pH 10, which is differentiated from CM β-cyclodextrin (β-CD). It can be interpreted as that the anionic repulsion effectively modulates the flexible and distorted conformation of CyS rather than rigid annular shape of β-CD. Resultingly, the highly solubilized CM CyS/pindolol complex was characterized by UV–vis, T1 relaxation, ROESY, DOSY NMR spectroscopy, FT-IR spectroscopy, SEM, and molecular modeling studies. The antioxidant activity of pindolol was also improved 260% in the complex compared to free pindolol. The use of flexible host molecules with pH-responsive substituents would be applied in the development of smart systems for sensing or in biomedical fields.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CM CyS was synthesized and evaluated as a flexible pH-responsive solubilizer of pindolol. </LI> <LI> The physicochemical properties of pindolol with CM CyS were investigated at pH 3 and 10. </LI> <LI> The complexation of CM CyS at pH 10 could enhance the antioxidant activity of pindolol. </LI> <LI> This work provides the insight on the design and development of smart host molecules. </LI> </UL> </P>
조은애,Yiluo Hu,최영진,정선호 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.63 No.-
We have reported a hybrid polymer composite, consisting of a supramolecular assembly of polydiacetylene (PDA) and phospholipid, that undergoes chromatic and fluorogenic changes after specific interactions with progesterone, the pregnancy hormone. Progesterone was selectively detected among 10 steroids by the mixed polymer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and PDA at an optimized ratio of 1:9. The triggering effect of progesterone on the membrane mimetic system were investigated using UV–vis, fluorescence, circular dichroism spectroscopy, Raman scattering, dynamic light scattering, transmission electron microscopy, and computational method. These results offer insight into self-assembly disruption and membrane targeting antibiotics as well as PDA-based sensing technology.
조은애,( Hu Yiluo ),정선호 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
In the present study, phospholipids/polydiacetylene supramolecules have been prepared, and dimyristoyl phosphatidylcholine(DMPC)/polydiacetylene(PDA) vesicles are evaluated as a selective progesterone sensory platform. In this biomimetic membrane interface, progesterone induces disassembly and segmental rearrangement of DMPC/PDA supramolecule, resulting in the blue-to-red color transition including fluorescence emission. The present study will provide new biosensor strategy, the drug action mechanism, and biomembrane modulation methods as well as the insight on progesterone receptor/inhibitor identification.
정다함,주상우,( Hu Yiluo ),조은애,정선호 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
In this study, a carboxymethyl cellulose (CMC) hydrogel containing carboxymethyl β-cyclodextrin (CMCD) was designed to improve the mechanical strength and swelling capacity of the superabsorbent CMC hydrogel. We synthesized cellulose (CEL), cyclodextrin/cellulose (CD/CEL), CMCD/CEL, CMC, CD/CMC, and CMCD/CMC hydrogels and their intrinsic mechanical strength and swelling capacity were evaluated. The structures and morphologies of all those hydrogels were characterized by various equipment. The storage modulus of the CMCD/CMC gel was nearly 8-fold higher than that of the CMC gel and maintained a high swelling ability. We also investigated the drug loading capacity and release properties using tetracycline as a drug model. CMCD/CMC hydrogels also showed the most effective tetracycline loading capacity with the highest antibacterial activity. Furthermore, this new hydrogel is a nontoxic, and bio-friendly, suggesting that it can be effective as a drug delivery system.