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Quadruple Primary Malignancies of Liver, Bladder, Lung and Stomach in One Patient
Yhim, Ho-Young,Kim, Hee Sun,Lee, Na-Ri,Kwak, Jae-Yong,Yim, Chang-Yeol,Park, Ho Sung,Song, Eun-Kee SAGE Publications 2010 TUMORI Vol.96 No.5
<P>Multiple primary malignancies are defined as two or more malignancies in an individual without any relationship between the tumors. Because of advances in the early detection, treatment, and supportive care for cancer, the number of cancer survivors has been gradually increasing, and this has led to an increase in the possible occurrence of subsequent malignancies. Recently, there have been reports that smoking is associated with a specific genetic mutation (the tumor suppressor gene TP53), and this genetic predisposition may be related to the development of multiple primary malignancies. Here we present a rare case of quadruple primary malignancies of the liver, bladder, lung and stomach, some of which possibly linked to smoking-related TP53 mutation. Because of its extreme rarity and the clear relationship between multiple primary malignancies and smoking-related TP53 mutation, we report this case along with a review of the relevant literature.</P>
YHIM, HO-YOUNG,CHO, SANG-HEE,KIM, SAM YONG,CHO, IN SUNG,LEE, KYU TAEK,LEE, WON SUP,LEE, SOON IL,PARK, MOO RIM,PARK, SANG-GON,HAN, HYE-SUK,CHOI, YOON SEOK,CHUNG, IK-JOO,SHIM, HYUN-JEONG,LEE, NA-RI,SONG Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.1
<P>Thymidylate synthase (TS) gene polymorphisms such as tandem repeat (TR) polymorphisms and single-nucleotide polymorphisms (SNPs) affect transcriptional efficiency of the TS gene and may be prognostic markers for fluoropyrimidine-based therapy in various gastrointestinal cancers. However, data for TS polymorphisms on clinical outcomes in advanced small bowel adenocarcinoma (SBA) are limited. We retrospectively enrolled 58 locally advanced/metastatic SBA patients treated with first-line fluoropyrimidine-based chemotherapy and analyzed the relationship between TS genotypes and clinical outcomes in 30 patients who were available for tumor tissue. Based on TR polymorphisms and a G>C SNP in the promoter region of the TS gene, 74% of patients had high TS expression genotypes (2R/3RG, 3RG/3RC, 3RG/3RG); the remainder had low TS expression genotypes (2R/2R, 2R/3RC, 3RC/3RC). After a median follow-up of 48.8 months, median progression-free survival (PFS) and overall survival (OS) in all patients were 6.0 and 11.3 months, respectively. However, patients with low TS expression genotypes had better median PFS (12.8 vs. 4.3 months, P=0.027) and OS (28.8 vs. 8.9 months, P=0.025) than those with high TS expression genotypes. In multivariate analysis, poor Eastern Cooperative Oncology Group performance status [hazard ratio (HR), 2.85; 95% CI, 1.02-7.93] and high TS expression genotypes (HR, 3.49; 95% CI, 1.13-10.78) were independent prognostic factors for worse OS. Therefore, TS genotypes, based on a G>C SNP in the TR sequence of the TS gene, may be a useful biomarker for predicting outcomes for fluoropyrimidine-based chemotherapy in patients with locally advanced/metastatic SBA.</P>
Yhim, Ho-Young,Han, Sae-Won,Oh, Do-Youn,Han, Wonshik,Im, Seock-Ah,Kim, Tae-You,Kim, Young Tae,Noh, Dong-Young,Chie, Eui Kyu,Ha, Sung Whan,Park, In Ae,Bang, Yung-Jue Wiley Subscription Services, Inc., A Wiley Company 2010 Cancer Vol.116 No.12
<B>BACKGROUND:</B><P>The aim of this study was to evaluate the clinical treatment outcomes of recurrent breast cancer with a limited number of isolated lung metastases, and to evaluate the role of pulmonary metastasectomy.</P><B>METHODS:</B><P>The authors consecutively enrolled 140 recurrent breast cancer patients with isolated lung metastasis from 1997 to 2007 in Seoul National University Hospital and retrospectively analyzed 45 patients who had <4 metastatic lesions.</P><B>RESULTS:</B><P>Fifteen patients had pulmonary metastasectomy followed by systemic treatment (pulmonary metastasectomy group), and 30 received systemic treatment alone (nonpulmonary metastasectomy group). The 3-year progression-free survival (PFS) and 4-year overall survival (OS) was significantly longer in the pulmonary metastasectomy group than in the nonpulmonary metastasectomy group (3-year PFS, 55.0% vs 4.5%, P < .001; 4-year OS, 82.1% vs 31.6%, P = .001). In multivariate analysis, a disease-free interval (DFI) of <24 months (hazard ratio [HR], 4.53; 95% CI, 1.72-11.90), no pulmonary metastasectomy (HR, 9.52; 95% CI, 3.34-27.18) and biologic subtypes such as human epithelial growth factor receptor-2 positive (HR, 3.00; 95% CI, 1.04-8.64) and triple negative (HR, 3.92; 95% CI, 1.32-11.59) were independent prognostic factors for shorter PFS.</P><B>CONCLUSIONS:</B><P>The authors' results demonstrated that DFI and biologic subtypes of tumor are firm, independent, prognostic factors for survival, and pulmonary metastasectomy can be a reasonable treatment option in this population. Further prospective studies are warranted to evaluate the role of pulmonary metastasectomy. Cancer 2010. © 2010 American Cancer Society.</P>
Yhim, H-Y,Kim, K,Kim, J S,Kang, H J,Kim, J-A,Min, C-K,Bae, S H,Park, E,Yang, D-H,Suh, C,Kim, M K,Mun, Y-C,Eom, H S,Shin, H J,Yoon, H-J,Kwon, J H,Lee, J H,Kim, Y S,Yoon, S-S,Kwak, J-Y Macmillan Publishers Limited 2013 Bone marrow transplantation Vol.48 No.3
The aims of this study were to investigate the outcomes of second salvage auto-SCT and to identify the impacts of a second auto-SCT compared with systemic chemotherapy alone on disease outcome. Data from 48 patients who underwent second auto-SCT were matched to 144 patients (1:3) who received systemic chemotherapy alone from the Korean Myeloma Registry. Groups were matched for nine potential prognostic factors and compared for treatment outcomes. The median age of matching-pairs at relapse was 55.5 years. A total of 156 patients (81%) received vincristine, doxorubicin and dexamethasone induction therapy before the first auto-SCT. Thirty-five patients (73%) in the second auto-SCT group received novel agent-based therapies before the second auto-SCT, and similar proportion in both groups received novel therapies after relapse of front-line auto-SCT. With a median follow-up of 55.3 months, patients who underwent a second auto-SCT had significantly better median OS (55.5 vs 25.4 months, P=0.035). In multivariate analysis for OS, <18 months time to progression after first auto-SCT, International Staging System III and salvage chemotherapy alone were independent predictors for worse OS. The outcomes of second auto-SCT appear to be superior to those of systemic chemotherapy alone. A randomized trial comparing both treatment strategies is required.
우리나라의 주식시장에서 회계정보 유용성의 변동에 관한 실증연구
임학빈 ( Yhim Hark-p ),이지영 ( Lee Ji-young ) 한국회계정책학회 2005 회계와 정책연구 Vol.10 No.2
본 연구는 선행연구에서 제시한 다양한 연구모형에 의거하여 우리나라 주식시장에서 회계이익, 현금흐름, 순자산 장부가치와 같은 재무제표 변수들의 유용성이 어떻게 변동하였는지를 실증적으로 조사하였다. 이를 위해 1982년부터 2003년까지 증권거래소에 상장된 기업을 대상으로 재무제표변수와 시장변수 사이의 통계적인 관련성 분석에 초점을 두고 전체 표본의 횡단면적 회귀분석과 더불어 연도별로 회귀계수 및 설명력의 추세를 분석하였다. 주요 연구결과는 다음과 같다. 첫째, 이익 또는 현금흐름변수는 주식수익률의 횡단면적 변동을 매우 낮은 수준으로 설명하고 표본기간에 걸쳐 감소추세로 나타났다. 둘째, 전체 표본기간 동안 이익반응계수(ERC)와 현금흐름반응계수(CFRC)는 각각 변동의 폭이 매우 컸으나 증가 또는 감소를 입증할 통계적인 유의성은 발견되지 않았다. 셋째, 우리나라 시장에서 주가로 반영되는 회계정보의 가치관련성은 일반적인 예상과 달리 증가되었으며 특히, 1997년의 금융위기 직후 가치관련성이 급상승하였으며 이러한 상승은 순자산 장부가치의 가치관련성 감소를 충분히 상쇄할만한 이익정보의 가치관련성 증가가 주도하였다. This paper investigates whether the usefulness of financial statements variables such as earnings, cash flows, and book values of equity have been changed over time in Korean stock market. The research focus is primarily placed on analysis of the association between accounting data and market data.Our results are as follows. Earnings (cash flows) and change in earnings (cash flows) are appeared to be very low in explaining the cross-sectional variation in stock returns and this association, as measured by adjusted R 2 has been declining over time. However, in price level model, on average, book value of equity and earnings explain 17% of the variation in market value. It shows a distinct increase in the total explanatory power combined by the book values and earnings and less upward trend in the incremental explanatory power by book values and earnings, respectively. There was an increasing trend for the yearly adjusted R 2 after the Korean financial crisis, much contributed by the obvious upward trend in the earnings' incremental explanatory power during this period, suggesting that this trend is due to earnings becoming more relevant, more than offsetting the decline in the value relevance of book value.