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      • On the Best Linear Estimator of Mean Life

        Yeum, Joon Keun 동국대학교 재료과학연구소 1982 材料科學硏究所 論文集 Vol.2 No.-

        Failure Censored 표본으로부터 平均壽命에 대한 最良線型 推定量에 대하여 살펴봄. Let X_1≤X_2≤…≤X_r denote the r smallest ordered observations from a set of n independent observations on the exponential distribution. Then we can obtain the U.M.V.U.E of θ. However it is not the best linear estimator of θ.

      • On the Efficiency for Ridge Estimator

        Yeum,Joon Keun 동국대학교 자연과학연구소 1982 자연과학연구 논문집 Vol.2 No.-

        偏?推定量인 Ridge Estimator를 一般化 分散이라는 基準에서 最小自乘推定量과 비교함. Much attention has been paid to the bias of coefficients resulting from ridge regression. Looking at bias alone implies that ridge estimators are inferior. However, using the criterion of the generalized variance, ridge estimators are better than ordinary least square estimators.

      • Central Pressor Mechanisms of Bradykinin in 2-Kidney, 1 Clip Goldblatt Hypertensive Rats

        Yeum, Cheol-Ho,Jun, Jae-Yeoul,Yoon, Pyung-Jin The Korean Physiological Society 1992 대한생리학회지 Vol.26 No.1

        Central cardiovascular effects of bradykinin were examined in anesthetized normotensive (NTR) and 2-kidney, 1 clip Goldblatt hypertensive rats (GHR). Bradykinin ($0.5{\sim}10nmol$) was administered into the right lateral cerebral ventricle, while blood pressure and heart rate (HR) were continuously monitored. In both NTR and GHR, intracerebroventricular bradykinin produced a dose dependent increase in mean arterial pressure (MAP) without significant changes in HR. GHR were more sensitive in the pressor response than NTR. The pressor response to bradykinin was attenuated by treatment with hexamethonium (2.5mg/kg/min, IV) or phentolamine (2mg/kg, IV) in both NTR and GHR. Reserpine treatment (2mg/kg/day, intramuscularly,2 days) did not affect the central pressor effect of bradykinin in NTR but it attenuated the pressor effect in GHR. Pretreatment with indomethacin (10mg/kg, intraperitoneally) or saralasin ($20{\mu}g$/kg/min, IV) was without effects on the pressor response to bradykinin. These results indicate that the central pressor effect of bradykinin is, at least in part, due to excitation of the autonomic nervous activity. Mechanisms other than the enhanced sympathetic nervous activity ran. not be ruled out, However. It is also suggested that the sensitivity to bradykinin is increased in the GHR.

      • SCIESCOPUSKCI등재

        Effect of Naringin Pretreatment on Bioavailability of Verapamil in Rabbits

        Yeum, Cheul-Ho,Choi, Jun-Shik The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1

        The aim of present study is to investigate the effect of naringin on the pharmacokinetics of verapamil and its major metabolite, norverapamil in rabbits. The pharmacokinetic parameters of verapamil and norverapamil were determined after administering verapamil (9 mg/kg) orally to rabbits in the pretreated with naringin (1.5, 7.5, and 15 mg/kg). Naringin pretreatment significantly altered the pharmacokinetic parameters of verapamil. Compared with the control group (given verapamil alone), the $K_a,\;C_{max}$ and AUC of verapamil were significantly (p<0.05 or p<0.01) increased in the pretreatment of naringin, However there were no significant change in $T_{max}\;and\;t_{1/2}$ of verapamil. Consequently, pretreatment of naringin significantly (p<0.05, p<0.01) increased the AB% of verapamil significantly in a dose dependent manner (p<0.05 or p<0.01 ), and elevated the RB% of verapamil by 1.26- to 1.69-fold. the MR of verapamil were significantly (p<0.05) increased in the pretreatment of naringin, implying that pretreatment of naringin may effectively inhibit the CYP3A4-mediated metabolism of verapamil. In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil. Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement.

      • Effects of Vitamin K<sub>2</sub> on Adipogenic and Osteogenic Differentiation in Mesenchymal Stem Cells from Human Umbilical Cord Blood

        Yeum, Chung Eun,Park, Seung Yeon,Kang, Tae Jin,Han, Hoon,Chae, Gue Tae Trans Tech Publications, Ltd. 2007 Key engineering materials Vol.342 No.-

        <P>Mesenchymal stem cells(MSCs) have the potential to self-replicate, proliferate and differentiate into chondrocytes, adipocytes, osteocytes and myocytes. Recent studies indicate that vitamin K2 plays a role in bone metabolism. But the mechanism is still unclear. We evaluated effect of vitamin K2 on osteogenesis and adipogenesis of MSCs from umbilical cord blood(UCB). By exposing MSCs to osteogenic and adipogenic medium with and without vitamin K2, the effects of vitamin K2 were analyzed. The results showed that vitamin K2 inhibits adipogenesis while at the same time it stimulates osteoblastic differentiation. These data are expected to provide novel information needed for successful therapeutic development for various types of osteoporosis and similar diseases related to bone formation.</P>

      • Effect of disperse dye on the preparation of poly(vinyl acetate)/poly(vinyl alcohol)/disperse dye composite microspheres

        Yeum, Jeong H,Park, Sung M,Kim, Jong W,Choi, Jin H,Han, Sang I,Oh, Weontae,Cheong, In W,Deng, Yulin SAGE Publications 2014 Journal of composite materials Vol.48 No.18

        <P>Microspheres of poly(vinyl acetate)/poly(vinyl alcohol)/disperse dye composite were prepared through suspension polymerization followed by the heterogeneous saponification. The effects of disperse dye on the rate of polymerization and saponification of poly(vinyl acetate) were studied. It was found that the rate of polymerization of poly(vinyl acetate) decreased when the concentration of the disperse dye increased. Also, the rates of poly(vinyl acetate) saponification decreased dramatically by the addition of disperse dye. The presence of disperse dye has almost no effect on the microsphere morphology.</P>

      • Optimal Software Release Policies with Imperfect Debugging

        Yeum,Joon-Keun,Kim,Hee-Soo 동국대학교 자연과학 연구원 1999 자연과학연구 논문집 Vol.4 No.-

        This paper considers a software release policies for a software cost model with imperfect debugging by assuming that new faults are sometimes introduced when the faults originally latent in a software system are corrected and removed during the testing phase and operating phase. A software reliability model based on the NHPP is used. The optimal release polices to minimize the expected total software cost are discussed. Finally, numerical examples are shown to illustrate the results of the optimal polices.

      • KCI등재

        A Study on Relations between Corporate Citizenship, Corporate Reputation and Job Pursuit Intention

        YEUM, Ahyoung(염아영),Han, Eunkyoung(한은경) 한국광고홍보학회 2014 한국광고홍보학보 Vol.16 No.4

        본 연구는 기업의 시민정신과 평판이 구직자들의 구직의도 간의 영향을 살펴보았다. 기업 역시 사회를 구성하는 시민의 일원으로서 좋은 구성원이 되기 위해 행하는 일련의 노력들이 기업의 가장 중요한 무형자산 중 하나인 기업의 평판을 형성할 것이라고 보았다. 나아가 이렇게 형성된 긍정적인 기업시민정신과 평판을 구직자들이 기업에 대한 속성과 근무환경을 평가하는 단서로 사용할 것으로 예측하여, 특정 기업에 대한 구직의도를 형성하는데 영향을 미칠 것이라고 가정하였다. 구직의도가 형성되는 과정을 자세하게 살펴보기 위해 본 연구는 합리적행동이론을 연구모형에 적용하였다. 합리적행동이론의 두 가지 변인, 행위에 대한 태도와 주관적 규범을 매개변인으로 포함하였다. 연구결과 모든 차원의 시민정신과 구직자들의 구직의도 간에 직접적인 관계는 없는 것으로 나타났다. 하지만 기업시민정신은 기업의 평판을 평가하는데 있어서는 긍정적인 영향력을 미쳤다. 매개변인의 검증결과, 기업평판의 매개효과는 유의하게 나타나지 않았지만, 합리적 행동이론의 변인들은 기업시민정신과 구직의도 간의 관계를 매개하는 것으로 나타났다. The present study investigated the effects of perceived corporate citizenship and corporate reputation on job seekers’ pursuit intension. This study anticipated that the corporate efforts to be a good citizen would develope the corporate reputation assets, which is one of the most important intangible assets. And this positively perceived corporate citizenship and reputation were expected to be influential in improving positive intention about the organization because job seekers would use corporate citizenship and reputation as a signal to predict organization’s attributes or working environment. Moreover, in order to understand job seeker’s decision making process more in detail, this study applied the theory of reasoned action to the research model. Two variables of the theory such as attitude toward getting a job and subjective norm were examined as mediators. This study found that all dimensions of corporate citizenship had no direct effect on job seeker’s pursuit intention. However, corporate citizenship had positive effects on corporate reputation. In terms of meditating role of the relationship between corporate citizenship and job pursuit intention, corporate reputation failed to verify, but two variables of the theory of reasoned action completely meditated the relationship. It provided substantial support of the theory of reasoned action.

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