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Kim, Jin Taek,Kim, Yeonjung,Cho, Young Min,Koo, Bo Kyung,Lee, Eun Kyung,Shin, Hyoung Doo,Jang, Hak Chul,Choi, Jung Won,Oh, Bermseok,Park, Kyong Soo Blackwell Publishing Ltd 2009 Clinical endocrinology Vol.70 No.1
<P>Summary</P><P>Objective </P><P>Adiponectin receptors 1 and 2 (<I>ADIPOR1</I> and <I>ADIPOR2</I>) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues. We investigated whether common polymorphisms of <I>ADIPOR1</I> and <I>ADIPOR2</I> are associated with type 2 diabetes or its related phenotypes in Koreans.</P><P>Design and patients </P><P>By sequencing of the DNA samples from 24 unrelated Korean subjects, we selected seven single nucleotide polymorphisms (SNPs) from <I>ADIPOR1 </I>and four SNPs from <I>ADIPOR2 </I>for genotyping in 757 type 2 diabetic patients and 644 nondiabetic subjects.</P><P>Results </P><P>None of the SNPs were associated with the risk of type 2 diabetes. However, g.−7309A>G (rs75172865) in <I>ADIPOR1 </I>was associated with lower insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR). Thereafter, we transfected three different human cell lines with plasmids harbouring g.−7309A>G and found that this variant reduced the promoter activity of <I>ADIPOR1</I>. In <I>ADIPOR2</I>, g.−63442G (novel SNP) and g.33447T (rs1044471) were associated with smaller waist circumference.</P><P>Conclusions </P><P>None of the SNPs in either <I>ADIPOR1 </I>or <I>ADIPOR2</I> were associated with the risk of type 2 diabetes in Koreans. However, the altered activity of the <I>ADIPOR1 </I>promoter was associated with insulin resistance and SNPs of <I>ADIPOR2</I> were associated with waist circumference.</P>
Joint Identification of Genetic Variants for Physical Activity in Korean Population
Kim, Jayoun,Kim, Jaehee,Min, Haesook,Oh, Sohee,Kim, Yeonjung,Lee, Andy H.,Park, Taesung MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.7
<P>There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included information on PA intensity and duration. Metabolic equivalent of tasks were calculated to estimate the total daily PA level for each individual. In addition to single- and multiple-SNP association tests, a pathway enrichment analysis was performed to identify the biological significance of SNP markers. Although no significant SNP was found at genome-wide significance level via single-SNP association tests, 59 genetic variants mapped to 76 genes were identified via a multiple SNP approach using a bootstrap selection stability measure. Pathway analysis for these 59 variants showed that maturity onset diabetes of the young (MODY) was enriched. Joint identification of SNPs could enable the identification of multiple SNPs with good predictive power for PA and a pathway enriched for PA.</P>
Acupuncture Inhibits Kainic Acid–Induced Hippocampal Cell Death in Mice
Kim, Seung-Tae,Jeon, Songhee,Park, Hae Jeong,Hong, Mee-Sook,Jeong, Wu Byung,Kim, Jang-Hyun,Kim, Yeonjung,Lee, Hye-Jung,Park, Hi-Joon,Chung, Joo-Ho The Physiological Society of Japan 2008 JOURNAL OF PHYSIOLOGICAL SCIENCES Vol.58 No.1
<P>We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)–induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 μg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions.</P>
Associations of smoking with overall obesity, and central obesity:
Yeonjung Kim,Seong Min Jeong,Bora Yoo,Bitna Oh,Hee-Cheol Kang 한국역학회 2016 Epidemiology and Health Vol.38 No.-
OBJECTIVES: The association between smoking and obesity is a significant public health concern. Both are preventable risk factors of cardiovascular disease and a range of other conditions. However, despite numerous previous studies, no consensus has emerged regarding the effect of smoking on obesity. We therefore carried out a novel study evaluating the relationship between smoking and obesity. METHODS: A total of 5,254 subjects aged 19 years or older drawn from the 2010-2013 Korea National Health and Nutrition Examination Survey were included in this cross-sectional study. Smoking was examined both in terms of smoking status and the quantity of cigarettes smoked by current smokers. Multiple logistic regression analysis was used to assess the association between smoking and obesity. Overall obesity was defined as a body mass index (BMI) ≥25 kg/m2, and central obesity was defined as a waist circumference ≥90 cm for males and ≥85 cm for females. We adjusted for the possible confounding effects of age, sex, physical activity, alcohol consumption, and the presence of hypertension or diabetes. RESULTS: A statistically significant difference in central obesity according to smoking status was identified. Current smokers were more likely to be centrally obese than never-smokers (adjusted odds ratio,1.30; 95% confidence interval, 1.02 to 1.67). However, no significant association was found between smoking and obesity defined by BMI. Moreover, among current smokers, no statistically significant association was found between the daily amount of smoking and obesity or central obesity. CONCLUSIONS: Smoking was positively associated with central obesity. Current smokers should be acquainted that they may be more prone to central obesity.
Kim, Mirae,Song, Jaeho,Yu, Dabin,Kim, Younghoo,Bae, Seok Hwan,Park, Miri S.,Lim, Yeonjung,Cho, Jang-Cheon The National Institute of Biological Resources 2021 Journal of species research Vol.10 No.3
To obtain unrecorded freshwater bacterial species in Korea, water and sediment samples were collected from streams, lakes, and wetland of the Han River watershed in 2020. Approximately 800 bacterial strains were isolated on R2A agar after aerobic or anaerobic incubation, and identified using 16S rRNA gene sequences. A total of 28 strains, with ≥98.7% 16S rRNA gene sequence similarity with validly published bacterial species but not reported in Korea, were determined to be unrecorded bacterial species in Korea. The unrecorded bacterial strains were phylogenetically diverse and belonged to four phyla, eight classes, 13 orders, 19 families, and 25 genera. The unreported species were assigned to Acetobacter, Alsobacter, Mesorhizobium, Prosthecomicrobium, and Microvirga of the class Alphaproteobacteria; Vogesella, Formosimonas, Aquincola, Massilia, Acidovorax, and Brachymonas of the class Betaproteobacteria; Pseudoxanthomonas, Thermomonas, Lysobacter, Enterobacter, Kosakonia, and Acinetobacter of the class Gammaproteobacteria; Sulfuricurvum of the class Epsilonproteobacteria; Mycolicibacterium, Agromyces, Phycicoccus, and Microbacterium of the class Actinobacteria; Paenibacillus of the class Bacilli; Clostridium of the class Clostridia; and Flavobacterium of the class Flavobacteriia. The details of the unreported species, including Gram reaction, colony and cell morphology, biochemical characteristics, and phylogenetic position are also provided in the description of the strains.