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짝자래나무[Rhamnus yoshinoi] 가지 추출물에 의한 전립선암세포의 Wnt/β-catenin 분해 유도 활성 및 GC/MS 분석
강연경(Yeongyeong Kang),어현지(Hyun Ji Eo),김다솜(Da Som Kim),박영기(Youngki Park),박광훈(Gwang Hun Park) 한국식물생명공학회 2021 JOURNAL OF PLANT BIOTECHNOLOGY Vol.48 No.2
We evaluated the anti-cancer activity against human prostate cancer cells and the associated molecular mechanism of extracts from the branches of Rhamnus yoshinoi (RYB). Treatment with RYB suppressed viability of human prostate cancer cells (PC-3) and decreased protein levels of both β-catenin and T-cell factor 4 (TCF4). This was reflected in reduced TCF4 mRNA, but not decreased β- catenin mRNA. PC-3 cells were pretreated with the proteosome inhibitor MG132 before treatment with RYB, which blocked RYB-mediated down regulation of β-catenin in PC-3 cells, thus confirming that RYB promotes the proteasomal degradation of β-catenin. RYB induced β-catenin phosphorylation, and GSK-3β inhibition by LiCl blocked the phosphorylation and proteasomal degradation of β- catenin by RYB. These results suggest that GSK-3β may be an important upstream kinase for RYB-mediated regulation of β-catenin. Finally, GC/MS analysis of RYB identified 18 compounds. Based on these findings, RYB shows potential for development as a therapeutic agent for prostate cancer
강연경 ( Yeongyeong Kang ),( Denver Walitang ),( Poulami Chatterjee ),표채은 ( Chaeeun Pyo ),사동민 ( Tongmin Sa ) 한국환경농학회 2017 한국환경농학회 학술대회집 Vol.2017 No.-
Methane (CH4) is currently receiving great attention due to its severe impact on the environment as a greenhouse gas. The atmospheric concentration of methane is continuously increasing and its average concentration is around 1.87 mg L<sup>-1</sup>. Methane is produced in nature when methanogens digest plant material in the absence of oxygen. Methane emission from rice fields is one of the largest individual sources in the global budget of atmospheric CH<sub>4</sub>. Methane-oxidizing bacteria (MOB) are phylogenetically diverse groups defined by their ability to use methane as a major carbon and energy source. Aerobic MOB, which are widely present in natural environments, can utilize methane as the sole carbon and energy source through a unique enzyme system of methane monooxygenase (MMO). MMO has a soluble cytoplasmic form (sMMO) and a particulate membrane associated form (pMMO). The objective of this study is to investigate the presence of sMMO in Methylobacterium spp. The selected strains for the current study, Methylobacterium spp. were isolated from rice. MOB are a subset of a physiological group of bacteria known as methylotrophs. The sMMO consists of three components, proteins A, B, and C. Protein A is coded for by the mmoX, mmoY, and mmoZ genes. Protein B is coded for by the mmoB gene. Protein C is the reductase component of the enzyme and is coded for by the mmoC gene. The presence of sMMO in Methylobacterium spp. was proven through polymerase chain reaction (PCR) using mmoC specific primer. This results indicate that there were 18 out of 19 strains of Methylobacterium. spp with sMMO detected through PCR-based amplification of an mmoC gene. PCR products of the correct size (314 bp) were obtained with all of the Methylobacterium spp. used in this study. In the current study confirming the oxidative activity of the strains that contain the sMMO. Future study the growth of these isolates using methane as the sole carbon source and then assess methane oxidation potential of by gas chromatography and their contribution in atmospheric methane oxidation.
패션산업의 비용효율의 측정과 분해 : 방향거리함수를 중심으로
신연경 ( Yeongyeong Shin ),강상목 ( Sangmok Kang ) 한국생산성학회 2021 生産性論集 Vol.35 No.3
Fashion is no longer just meeting the basic needs of human life, but it is becoming an important medium for expressing individuality, identity, and taste of individuals, and even for expressing a country's culture. Despite the economic downturn, people's interest in fashion and the fashion industry has not diminished, and in many ways it is expanding. According to the data released by the Korea Federation of Textile Industries, the size of the domestic fashion market was 43.187 trillion won in 2016, 42.47 trillion won in 2017, 43.2181 trillion won in 2018, and 41.64 trillion won in 2019. This amount is more than 40 trillion won, including 2018 which is the largest year compared to the past 20 years. The types that make up the fashion industry also vary in casual, sports clothes, suits, and baby clothes, and for the fashion industry to continue to diversify and develop the kinds that meet the needs of the times, it must be accompanied by steady efforts of domestic fashion companies. In the long run, in order for the government to create the necessary policies related to the fashion industry or seek ways of innovation in the company itself, it must be preceded by analyzing the cost inefficiency of the company and identifying the detailed causes of inefficiency. In addition, the analysis of inefficiency should be preceded by the major companies leading the fashion industry, and efforts to improve the efficiency of the major companies can be actively used as examples of small companies. Therefore, this study analyzed the efficiency of 19 KOSPI and KOSDAQ listed companies, which represent the Korean fashion industry. It was targeted for four years from 2016 to 2019, and aims to measure the directional cost efficiency using the directional distance function using the Data Environment Analysis (DEA). It also analyzes the association between measured cost efficiency and value added, and further decomposes the measured cost efficiency into technology efficiency and allocation efficiency. As a result of measuring cost efficiency, the overall average cost efficiency of 19 entities over the period 2016-1919 was 0.540, with significant cost inefficiency for each entity. Looking at the overall average by year, 2016 was 0.577 and 2017 and 2018 seemed to improve gradually as a result of 0.513, 0.514, respectively, but cost efficiency rose again to 0.556 in 2019, still requiring steady efforts to narrow the gap and the figure of cost inefficiency of companies. In addition, this study analyzed the association with the average cost-effectiveness of 2016-2019 by ranking 19 companies in the order of high average added value for the four years of 2016-2019. As a result, high added value does not necessarily mean good cost efficiency. It can be seen that companies with very high added value are also operating with very low efficiency apart from added value. As a result, companies need to focus not only on increasing value added, but on improving inefficiency, which is prevalent in companies that can be seen as visible side effects. In this work, we analyze the causes of this inefficiency improvement and decompose the measured cost efficiency into technology efficiency and allocation efficiency using directional functions to present implications. As a result, it has been shown that the main cause of inefficiency lies in technology inefficiency. As a result of this study, measures should be actively sought to reduce inefficiency prevalent in fashion companies, such as innovation in organizational culture, efficient input of resources, and effective government policies.
강연경,KANG, Yeongyeong 국립문화재연구원 2022 헤리티지:역사와 과학 Vol.55 No.3
Lacquer, in addition to high-end crafts such as lacquerware inlaid with mother-of-pearl, was an important strategic material used in a wide range of fields such as industry, architecture, and munitions during the Japanese colonial era. In particular, as the demand for lacquer used in munitions soared in the 1940s when the war started, a ticket system was introduced to restrict its distribution. Meanwhile, Japan experienced a chronic shortage of lacquer as a result of the rapidly increasing demand for it, and thus went on to import Chinese lacquer after the late 19th century. After the 1910s, the market share of Chinese lacquer reached 90%, and the local situation in China began to affect the supply and demand for lacquer in Japan. To counteract the issue, the Japanese government increased the production of lacquer in Joseon. As for the project to increase lacquer production in Joseon, objective indicators were prepared through a number of tests in the 1910s and 20s, which paved the way for the project to begin in earnest in the 1930s. Lacquer trees were planted and training classes on how to collect lacquer were held throughout the country. The Japanese government promoted the lacquer production industry as a promising side job for Koreans. The project, implemented in various parts of the country, reaped fruitful results, and it provided the basis for lacquer production in Korea that has continued to this day. At that time, the major regions in the southern part of the country where the project was concentrated were Wonju, Okcheon, and Hamyang, regions that are still known today as major production sites. The improved method of collecting lacquer taught to Koreans by the Japanese has now become the main method of collecting lacquer in Korea. This study attempts to identify the current status of the project to increase lacquer production through various records from the Japanese colonial era with a view to contributing to the study of modern lacquer craft history.
공중보건 위기대응 의료제품의 개발 촉진 및 긴급 공급을 위한 특별법 고찰 및 FDA와 EMA의 유사 법안 비교 분석
김선영(Sunyoung Kim),한연경(YeonGyeong Han),문은희(EunHui Moon),강석연(SeokYeon Kang),강원구(Wongu Kang),원정우(Jeongwoo Won),정시연(Si-Yeon Jeong) 대한약학회 2022 약학회지 Vol.66 No.3
Since the outbreak of the new strain of coronavirus (SARS-CoV-2, COVID-19) was first reported, regulatory authorities worldwide have issued various regulatory guidelines and recommendations. Global authorities are committed to supporting developers of potential vaccines and treatments for COVID-19. This study reviewed the guidelines and regulatory procedures instituted by authorities in the United States and Europe to understand the current perspectives of regulatory agencies worldwide and derive implications for public health emergency responses. The Act on Encouragement of Development and Emergency Circulation of Medical Countermeasures for public health emergencies enacted in 2021 established the Ministry of Food and Drug Safety (MFDS) to oversee policies for public health emergencies. In the US, the Public Law 113-5, the PHS Act, the PREP Act and the FD&C Act grant authorities emergency use power with respect to medical countermeasures needed during public health emergencies. The FDA can also facilitate the use of those medical countermeasures. The EMA has accelerated regulatory procedures in place for expediting the development and approval of medicinal products for COVID-19. The EMA’s rapid procedure includes rolling review, accelerated assessment and conditional marketing authorisation. Based on the review of foreign policies and practices regarding public health emergencies, this study showed that the Act on Encouragement of Development and Emergency Circulation of Medical Countermeasures for public health emergency responses has made important advances in public health emergency preparedness and response.
어현지,권혜윤,Som Da Kim,Kang Yeongyeong,Park Youngki,박광훈 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Hibiscus syriacus (H. syriacus), which belongs to Malvaceae, is a perennial herb widely distributed in East Asia. In this study, we investigated the anti-infammatory efects and its potential molecular mechanisms of leaves extracted with 70% ethanol of H. syriacus (HS-L) at the mRNA and protein level when RAW264.7 macrophages were stimulated by LPS. HS-L dose dependently (0, 25, 50, 100 μg/mL) reduced NO production by inhibiting iNOS, COX-2, and IL-β expression in LPS�induced RAW264.7 macrophages. HS-L decreased the LPS-stimulated degradation and phosphorylation of IkB-a. Moreover, treatment with HS-L suppressed LPS-induced DNA binding of NF-kB and nuclear translocation of p65. Furthermore, HS-L suppressed the phosphorylation of ERK1/2 and p38. HS-L was analyzed to contain compounds such as 2-pentadecanone, methyl palmitate, and ethyl palmitate in GC/MS analysis. These results suggested that HS-L could utilize anti-infammatory activity by inhibiting NF-κB and MAPKs signaling pathways and that HS-L could be used as a natural anti-infammatory agent.