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Polyphenol-rich apples induces the differentiation and mineralization in osteoblastic MC3T3-E1 cells
Yejin Sim,Hyun-Ju Seo,In-Sook Kwun,Young-Eun Cho 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The bioactive polyphenol compounds were known as bone health benefit that inhibits osteoclastogenesis and promotes osteoblastogenesis. However, the osteogenic activity of polyphenol-rich apples needs to be comprehensively elucidated. In this study, whether polyphenol-rich apples modulate the differentiation and mineralization in osteoblasts MC3T3-E1 cells after treatment for 3 and 7 days was investigated. In our results, we showed that apples stimulate osteoblastic differentiation and mineralization, manifested by the up-regulation of differentiation markers (alkaline phosphatase and osteogenic mRNAs) and von Kossa/Alizarin Red staining, respectively. In addition, apples were elevated the expression levels of osteoblast differentiation genes and proteins in osteoblastic MC3T3-E1 cells through modulating the BMP2 signaling pathway. This suggests that polyphenol-rich apples stimulate osteoblast differentiation/mineralization and could be used as an effective strategy to prevent the osteoporosis.
갈색거저리 및 동애등에 유충 오일의 급성 알코올성 간독성 및 장내누수증에 미치는 영향
심예진(Yejin Sim),김동하(Dongha Kim),표수진(Su-Jin Pyo),손호용(Ho-Yong Sohn),정철의(Chuleui Jung),김도균(Do-Kyun Kim),조영은(Young-Eun Cho) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.11
본 연구는 갈색거저리 및 동애등에 유충 오일의 간 손상 및 장내누수증의 억제 효능을 확인하고자 하였다. 갈색거저리와 동애등에 유충 오일을 처리한 후에 알코올을 먹인 그룹에서 간 조직의 중성지방 함량을 감소시킨다는 것을 확인할 수 있었으며, 간 조직의 H&E 및 Oil-red O 염색 결과 lipid droplet이 감소함을 확인하였다. 갈색거저리와 동애등에 유충 오일을 처리한 후에 알코올을 먹인 그룹에서 지방대사에 관련된 유전자인 PPARγ, C/EBPα, SREBP-1c, FAS 유전자 발현이 유의적으로 감소하는 것을 확인하였다. 또한, 급성 알코올에 의해 증가한 장내독소 및 염증 인자인 TNF-α의 발현이 갈색거저리와 동애등에 유충 오일 투여로 억제되는 효과를 가지고 있는 것을 확인하였다. 또한 상기 유충오일들은 알코올 섭취에 의해 증가한 활성산소종에 의한 산화적 손상을 예방하는 효과를 보여주었다. 장내누수증의 원인이 되는 장벽의 손상을 확인한 결과 EtOH 그룹의 TJ/AJ 단백질 발현 정도는 정상군보다 감소한 것을 알 수 있었으며, 갈색거저리 및 동애등에 유충 오일은 알코올에 의한 장벽 손상을 억제하였다. EtOH 그룹의 증가한 CYP2E1과 iNOS 소장 단백질 발현 역시, 갈색거저리 및 동애등에 유충오일 투여에 의해 억제됨을 확인하였다. 본 연구는 갈색거저리 및 동애등에 유충 오일이 급성 알코올에 의해 나타나는 간 손상 및 장내 산화 스트레스 및 장벽 손상을 억제하는 효과를 가짐을 제시하고 있다. 곤충의 기능성 및 임상 연구 등을 통해 건강 우수성에 관한 연구뿐만 아니라 다양한 메뉴개발과 함께 일반인들이 곤충을 친숙하게 만날 수 있도록 요구되는데, 곤충의 유충에서 분리한 오일의 실용화 면에서 중요한 결과라고 사료된다. Alcoholic liver disease (ALD) is a major chronic liver disease worldwide and it arouses simple steatosis, inflammation, fibrosis and cirrhosis, possibly through leaky gut and systemic endotoxemia. This study investigated whether the insects oils from larvae of mealworm (Tenebrio molitor) or black soldier fly (Hermetia illucens) could protect against binge alcohol-induced gut leakiness, endotoxemia, and fatty liver damage. After pretreatment of the insect larvae oils of mealworm or black soldier fly for 14 days, mice were exposed to 3 oral doses of binge alcohol (6 g/kg/dose) or dextrose (as control) at 12 h intervals. Binge alcohol exposure induced leaky gut with significantly elevated plasma endotoxin and inflammatory fatty liver by increasing the levels of ethanol-inducible CYP2E1, inducible nitric oxide synthase, and nitrated proteins in the small intestine and liver. The insect larvae oils of mealworm or black soldier fly significantly reduced the alcohol-induced gut barrier dysfunction, plasma endotoxin and inflammatory liver disease by inhibiting the elevated oxidative and nitrative stress marker proteins. The insect larvae oils of mealworm or black soldier fly significantly restored the levels of intestinal tight junction (TJ) protein (ZO-1) and adherent junction (AJ) protein (β-catenin) markedly diminished after alcohol-exposure. This is the first report that the insect oils from larvae of mealworm or black soldier fly could prevent alcohol-induced gut leakiness and fatty liver damage.
일반학생, 읽기부진학생 및 지적장애학생의 읽기유창성 특성과 읽기 오류 유형 비교 분석
심예진 ( Sim Yejin ),정평강 ( Jung Pyung-gang ) 한국지적장애교육학회 2022 지적장애연구 Vol.24 No.1
본 연구는 일반학생, 읽기부진학생 및 지적장애학생의 읽기유창성 특성과 읽기 오류 유형을 비교 분석함으로써 학생의 특성을 고려한 맞춤형 읽기유창성 교수 방안을 탐색하는 데 목적이 있다. 이에 따라 초등학교 2~3학년 일반학생과 읽기부진학생, 학령기 지적장애학생 총 51명을 대상으로 이야기글과 설명글로 구성된 읽기유창성 검사를 실시한 후, 읽기유창성 속도와 정확도, 어절과 글 수준에서의 읽기 오류 유형을 살펴보았다. 연구 결과로 첫째, 읽기유창성 속도는 일반학생이 읽기부진학생과 지적장애학생보다 높은 것으로 나타났고, 정확도는 일반학생이 읽기부진학생보다 높은 것으로 나타났다. 둘째, 어절 수준 오류분석 결과, 읽기부진 학생이 일반학생에 비해 음운변동 오류를, 지적장애학생에 비해 첨가 오류를 더 많이 보이는 것으로 나타났다. 글 수준 오류분석 결과, 지적장애학생은 일반학생보다 의미와 문법 모두 허용 불가능한 오류를 더 많이 보이는 것으로 나타났다. 이와 같은 각 집단의 읽기유창성 특성 및 오류 분석 결과에 대한 유사점과 차이점을 바탕으로 각 집단의 읽기 특성을 고려한 읽기 유창성 교수 방안에 대한 함의를 논의하였다. The purpose of this study was to examine the characteristics of oral reading fluency and types of reading errors of typically developing students, and students with underachievement of reading who are in elementary grades 2~3, and students with intellectual disabilities. Ultimately, we would like to suggest customized reading fluency intervention depending on their unique characteristics. For the purpose of this study, A total of 51 students were administered reading fluency assessment consisted of story and explanation articles. We analyzed their speed, accuracy and types of reading errors at the word-level and the text-level. The research results are as follows. First, it was found that typically developing students read faster than students with underachievement in reading and students with intellectual disabilities. And typically developing students read more accurately than students with underachievement in reading. Second, at the word-level, students with underachievement of reading showed more ‘phoneme conversion’ errors than typically developing students, and ‘added’ errors more than students with intellectual disabilities. Next, at the text-level, students with intellectual disabilities showed more ‘unallowable errors in both meaning and grammar’ than typically developing students. Based on the results of this study, the implications of the reading fluency intervention method considering the reading characteristics of each group were discussed based on the similarities and differences between the reading fluency characteristics and error analysis results of each group.
Jeongmi Shin,Yejin Kim,Shin Hye Yoo,Jin-Ah Sim,Bhumsuk Keam 한국호스피스완화의료학회 2022 한국호스피스.완화의료학회지 Vol.25 No.4
Purpose: Social distancing and strict visitor restrictions at hospitals have been national policies since the onset of the coronavirus disease 2019 (COVID-19) pandemic. This has challenged the concept of a good death in comfort with the opportunity to say goodbye. Little is known about how these measures have influenced end-of-life (EOL) care among cancer patients who die in acute care hospitals. This study examined changes in the EOL care of cancer patients during the COVID-19 pandemic. Methods: We retrospectively analyzed 1,456 adult cancer patients who died in 2019 (n=752) and 2020 (n=704) at a tertiary hospital. Data on EOL care—symptom control and comfort care in an imminently dying state, preparation for death, place of death, and aggressive care in the last month— were reviewed. Results: The 1,456 patients had a median age of 67 years, and 62.5% were men. Patients who died in 2020 were more likely to experience agitation or delirium before death (17.2% vs. 10.9%), to use inotropes/vasopressors near death (59.2% vs. 52.3%), and to receive cardiopulmonary resuscitation in their last months (16.3% vs. 12.5%) than those who died in 2019. Additionally, the number of deaths in the emergency room doubled in 2020 compared to 2019 (from 7.1% to 14.1%). Conclusion: This study suggests that EOL care for cancer patients who died in a tertiary hospital deteriorated during the COVID-19 pandemic. The implementation of medical care at the EOL and the preferred place of death should be discussed carefully in advance for high-quality EOL care.
A case of fibroepithelial polyp developed on the sole
( Kihun Kim ),( Yejin Lee ),( Barklynn Lew ),( Wooyoung Sim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Fibroepithelial polyp is commonly known as a skin tag. This is a benign, pedunculated and papillomatous growth of skin mainly composed of epidermal and stromal component. Fibroepithelial polyp is the most commonly found in neck and axilla, though any skin fold may be affected like groin area. However, it may present at unusual sites of the body such as the penis, urethra, and vulva. Herein, we report an interesting case of a fibroepithelial polyp arising from the sole. A 70-year old woman presented with a 10-year history of a painful nodule on lateral metatarsal area of left sole. The lesion demonstrated a solitary 1.0x1.2 cm sized, skin colored, firm, nodule on the left sole. Nodule makes pain and tenderness with walking. Total surgical excision was performed under the clinical impression of eccrine poroma. Histopathological findings revealed papillomatosis, hyperkeratosis, and acanthosis of epidermis with ill circumference fibro-collagenous tissue and dilated capillaries in the dermis. Based on these findings, we diagnosed as a fibroepithelial polyp. Although fibroepithelial polyp on the sole is an unusual presentation, it should also be considered as a differential diagnosis when diagnosing mass on the soles.