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Electrochemically active, anti-biofouling polymer adlayers on indium-tin-oxide electrodes
Kim, Eun Jeong,Shin, Hee-Young,Park, Sangjin,Sung, Daekyung,Jon, Sangyong,Sampathkumar, Srinivasa-Gopalan,Yarema, Kevin J.,Choi, Sung-Yool,Kim, Kyuwon Royal Society of Chemistry 2008 Chemical communications Vol.2008 No.30
<P>Here we report the synthesis of a novel electrochemically active polymer, preparation of adlayers of the polymer on optically transparent electrodes, and an application of the adlayers to immobilization of engineered cells through a direct covalent coupling reaction.</P> <P>Graphic Abstract</P><P>The authors report the synthesis and application of an electrochemically active, anti-biofouling polymer. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b804816a'> </P>
General and Facile Coating of Single Cells via Mild Reduction
Kim, Hyunbum,Shin, Kwangsoo,Park, Ok Kyu,Choi, Daheui,Kim, Hwan D.,Baik, Seungmin,Lee, Soo Hong,Kwon, Seung-Hae,Yarema, Kevin J.,Hong, Jinkee,Hyeon, Taeghwan,Hwang, Nathaniel S. American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.4
<P>Cell surface modification has been extensively studied to enhance the efficacy of cell therapy. Still, general accessibility and versatility are remaining challenges to meet the increasing demand for cell-based therapy. Herein, we present a facile and universal cell surface modification method that involves mild reduction of disulfide bonds in cell membrane protein to thiol groups. The reduced cells are successfully coated with biomolecules, polymers, and nanoparticles for an assortment of applications, including rapid cell assembly, in vivo cell monitoring, and localized cell-based drug delivery. No adverse effect on cellular morphology, viability, proliferation, and metabolism is observed. Furthermore, simultaneous coating with polyethylene glycol and dexamethasone-loaded nanoparticles facilitates enhanced cellular activities in mice, overcoming immune rejection.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2018/jacsat.2018.140.issue-4/jacs.7b08440/production/images/medium/ja-2017-08440m_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja7b08440'>ACS Electronic Supporting Info</A></P>