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Yaqiong Zhu,Nan Peng,Jing Wang,Zhuang Jin,Lianhua Zhu,Yu Wang,Siming Chen,Yongqiang Hu,Tieyuan Zhang,Qing Song,Fang Xie,Lin Yan,Yingying Li,Jing Xiao,Xinyang Li,Bo Jiang,Jiang Peng,Yuexiang Wang,Yukun 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3
Background: Developing biocompatible nerve conduits that accelerate peripheral nerve regeneration, lengthening and functional recovery remains a challenge. The combined application of nerve microtissues and platelet-rich plasma (PRP) provides abundant Schwann cells (SCs) and various natural growth factors and can compensate for the deficiency of SCs in the nerve bridge, as well as the limitations of applying a single type of growth factor. Multimodal ultrasound evaluation can provide additional information on the stiffness and microvascular flow perfusion of the tissue. This study was designed to investigate the effectiveness of a novel tissue-engineered nerve graft composed of an autogenous vein, nerve microtissues and PRP in reconstructing a 12-mm tibial nerve defect and to explore the value of multimodal ultrasound techniques in evaluating the prognosis of nerve repair. Methods: In vitro, nerve microtissue activity was first investigated, and the effects on SC proliferation, migration, factor secretion, and axonal regeneration of dorsal root ganglia (DRG) were evaluated by coculture with nerve microtissues and PRP. In vivo, seventy-five rabbits were equally and randomly divided into Hollow, PRP, Micro-T (Microtissues), Micro-T + PRP and Autograft groups. By analysing the neurological function, electrophysiological recovery, and the comparative results of multimodal ultrasound and histological evaluation, we investigated the effect of these new nerve grafts in repairing tibial nerve defects. Results: Our results showed that the combined application of nerve microtissues and PRP could significantly promote the proliferation, secretion and migration of SCs and the regeneration of axons in the early stage. The Micro-T + PRP group and Autograft groups exhibited the best nerve repair 12 weeks postoperatively. In addition, the changes in target tissue stiffness and microvascular perfusion on multimodal ultrasound (shear wave elastography; contrast-enhanced ultrasonography; Angio PlaneWave UltrasenSitive, AngioPLUS) were significantly correlated with the histological results, such as collagen area percentage and VEGF expression, respectively. Conclusion: Our novel tissue-engineered nerve graft shows excellent efficacy in repairing 12-mm defects of the tibial nerve in rabbits. Moreover, multimodal ultrasound may provide a clinical reference for prognosis by quantitatively evaluating the stiffness and microvescular flow of nerve grafts and targeted muscles
Gene expression profile of NFκB repressing factor(NKRF) knockdown cells by microarray analysis
Sun Yaqiong,Zheng Dan,Gu Shaohua,Mao Yumin,Xie Yi 한국바이오칩학회 2012 BioChip Journal Vol.6 No.3
Human NFκB repressing factor(NKRF) is a negative regulation transcription factor, which is able to repress transcription by binding to the negative regulatory element(NRE) near the NFκB binding site in certain genes’ promoters. Current researches reveals that NKRF represses the activation of IFN-β, IL-8,hiNOS and HIV-1 by NFκB. We used optical fiber beadchip to analysis the different gene expression patterns of RNAi mediated NKRF knockdown HEK293 cells and found that several genes showed significant change of expression levels. Real-time PCR was performed to verify the changes of expression of candidate genes. We analyzed the function of candidate genes by searching the gene ontology databases and publications and revealed that these genes functioned in cell cycle, cell proliferation, apoptosis, cell migration, DNA repair, transcription, metabolism, response to stimulus and signal transduction. This study provides new perspectives on NKRF’s potential multiple functions.
Analysis of plane frame structure using base force element method
Yijiang Peng,Yaqiong Bai,Qing Guo 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.1
The base force element method (BFEM) is a new finite element method. In this paper, a degenerated 4-mid-node plane element from concave polygonal element of BFEM was proposed. The performance of this quadrilateral element with 4 mid-edge nodes in the BFEM on complementary energy principle is studied. Four examples of linear elastic analysis for plane frame structure are presented. The influence of aspect ratio of the element is analyzed. The feasibility of the 4 mid-edge node element model of BFEM on complementary energy principles researched for plane frame problems. The results using the BFEM are compared with corresponding analytical solutions and those obtained from the standard displacement finite element method. It is revealed that the BFEM has better performance compared to the displacement model in the case of large aspect ratio.
Jinru Luo,Yaqiong Yan,Jishan Zhang,Linzhong Zhuang 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.4
A strongly basal textured AZ31 magnesium alloy were cryorolled at liquid-nitrogen temperature at various strains. The microstructure and texture of the rolled sheets have been investigated using electron backscatter diffraction (EBSD) and X-ray diffraction. The microstructural and textural evolutions of the AZ31 magnesium alloy during cryorolling have been discussed. A lot of twins were observed in the rolled sheets. The influence of strain on the twin types and variant selection during cryorolling for the magnesium alloy has been discussed quantitatively based on the orientation data collected using EBSD. The influence of the twins on the microstructural and textural evolutions for the AZ31 magnesium alloy during cryorolling has also been discussed. The mechanical properties of the cryorolled sheets were tested by uniaxial tensile tests at the ambient temperature with a strain rate 10 -3 s -1 in the tensile direction respectively along the rolling and transverse directions of the rolled sheets. The relationships between the mechanical properties and microstructure of the cryorolled sheets have been discussed in the present work. The active twinning during rolling at that cryogenic temperature has been found to play an important role in influencing the microstructure, texture, as well as the mechanical properties of the AZ31 magnesium alloy.
Long, Xingle,Chen, Yaqiong,Du, Jianguo,Oh, Keunyeob,Han, Insoo Elsevier 2017 Energy Policy Vol.107 No.-
<P><B>Abstract</B></P> <P>This paper analyses the impact of environmental innovation on the economic and environmental performance of Korean-owned firms in China. We establish a theoretical model and propose eight hypotheses, which combine TPB (Theory of Planned Behavior) with theories of global environmental management and environmental innovation. We analyse the determinants of environmental innovation intention. We also analyse the effects of environmental innovation behavior on economic performance and environmental performance in different provinces and of different corporate ownership. We find that environmental innovation behavior has a greater effect on environmental performance than economic performance. Innovation in production processes, in particular, positively affects environmental performance for Korean-owned firms in Jiangsu. We also find that wholly Korean-owned firms (WKOEs) are more receptive to environmental innovation than Sino-Korean joint ventures. It is important to enhance environmental innovation within Korean-owned firms in China. Environmental innovation should concentrate on improving production processes in Jiangsu.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Environmental innovation behavior has a greater effect on environmental performance than economic performance. </LI> <LI> Innovation in production processes positively affects environmental performance for Korean-owned firms in Jiangsu. </LI> <LI> Environmental innovation should concentrate on improving production processes in Jiangsu. </LI> </UL> </P>