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( Ying Huang ),( Chenjie Xu ),( Tao Zeng ),( Zhongming Li ),( Yanzhi Xia ),( Gaojian Tao ),( Tong Zhu ),( Lijuan Lu ),( Jing Li ),( Taiyuan Huang ),( Hongbo Huai ),( Benxiang Ning ),( Chao Ma ),( Xinx 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.2
Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.
The preparation of alginate–AgNPs composite fiber with green approach and its antibacterial activity
Xihui Zhao,Qun Li,Xiaomei Ma,Wanying Liu,Jianping Wang,Yanzhi Xia 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.24 No.-
Antibacterial alginate fibers containing silver nanoparticles (AgNPs) have been prepared in this work. Firstly, AgNPs colloid solution was obtained employing alginate as stabilizing agent and glucose as reducing agent. Then, sodium alginate powder was directly added to the above solution and the resultant sodium alginate–AgNPs spinning dope was spun to prepare alginate–AgNPs composite fibers. The fibers were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and thermal gravimetric analysis (TG). Mechanical properties of the fibers were also measured. The antimicrobial properties were investigated by Staphylococcus aureus and Escherichia coli, and the results indicated that the composite fibers showed strong antibacterial activity.
Zhaoyi Li,Liang Sun,Zhongjun Fu,Yuchao Li,Zhaohui Jiang,Bingtao Tang,Quan Ji,Yanzhi Xia,Ming Wang,Haofei Huang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.3
Calcium alginate fiber is a biomaterial with promising application in textile industry. However, the poor dyeingproperty of this fiber restricts its development. In this study, three PVAm (polyvinylamine) dyes were applied to the exhaustdyeing of calcium alginate fiber and their dyeing behavior under different dyeing conditions was studied. The dyeing resultsrevealed that PVAm dyes were firmly adsorbed on calcium alginate fiber by coordination bonding formed between theprimary amino groups in PVAm backbones of dyes and Ca2+ ions in calcium alginate fiber. This special complex dyeingmode was further confirmed by a Langmuir-type adsorption manner of PVAm-1 dye for calcium alginate fiber. By theformation of this stable chelation structure between dyes and fibers, high exhaustion rates (88.9-97.1 %) and excellent colorfastness were obtained. SEM and XRD results also showed that the surface and crystal phase of dyed fibers had very slightchanges compared to those of original calcium alginate fibers. The strength property of the fiber was also maintained wellafter this special complex dyeing process.