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Effects of naringin on fibrosis in a rats model with polycystic ovary syndrome (PCOS)
Zhewen Dong,Huan Lan,Wanying Li,Qi Qi Pang,Jia- Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To observe the effect of naringin intervention and its ameliorating effect on ovarian fibrosis in letrozole induced POCS rats. SD rats were divided into normal, PCOS and naringin group. The body weight(BW) was recorded every 3 days. ELISA kits were used to measure serum levels of FSH, LH, E2, and T in PCOS rats. The levels of CollagenI, CTGF, α-SMA were detected by Western Blotting assay. The BW of PCOS rats were significantly increased than that in control group (P<0.05). Naringin treatment reduced the BW in PCOS rats. Compared with normal group, the serum level of E2 in PCOS group was decreased, and the serum T, LH, FSH, LH/FSH ratio levels were increased. However, administrated with naringin increased the serum E2 levels, and also decreased the serum levels of T, LH, FSH, LH/ FSH levels in PCOS rats. The protein levels of CollagenI, CTGF and α-SMA were increased in varian of PCOS rats than that in normal group. Naringin treatment was able to decrease the protein levels of CollagenI, CTGF and α-SMA in varian of PCOS rats.The results showed that naringin intervention could improve the metabolic imbalance and the occurrence of fibrosis in PCOS rats.
Chaojie Chong,Yaqi Wu,Zhewen Dong,Zixian Wang,Shumei Zhong,Haokun Chen,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was to investigate the ameliorative effect of GFPS on clinical symptoms in letrozole(1 mg/kg)-induced PCOS rats. The female SD rats were classified into 4 groups as follows: the normal group (gavaged with saline), the PCOS group(ingested letrozole daily for 21 days). Normal group and metformin group gavaged with letrozole followed by metformin (265 mg/kg) and GFPS(600 mg/kg), respectively. All rats were weighed every 3 days until the end of the experiment. The ovaries, perirenal, abdomen and periuterine fat were removed and the relative weights (g/bw×100) were calculated. Serum levels of FSH, LH, E2, T, TG, TC, LDL-C were measured by ELISA and calculated the LH/FSH ratio. GFPS reduced follicle number and increases granulosa cell layer thickness and luteal number. GFPS also reduced the increase of body weight, ovarian and visceral fat weight in PCOS rats (P<0.01). In addition, GFPS reduced the serum levels of T, LH/FSH, TC, TG, LDL-C and LH, and elevated the serum levels of E2 and FSH in PCOS rats. In conclusion, GFPS can improve follicular development and restore body weight, ovarian weight, serum hormone levels and lipid profile in PCOS rats.
Yaqi Wu,Chaojie Chong,Zhewen Dong,Zixian Wang,Haokun Chen,Shumei Zhong,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To explore the ameliorative effect of Phellinus linteus polysaccharide(PLP) on letrozole-induced PCOS rats. A total of 32 female SD rats were randomly divided into normal group, PCOS group, metformin group and PLP group, and weighed every three days. The estrous cycle of rats was observed by vaginal smear ten days before sacrifice. The estrous cycle of PCOS rats was disordered, the ovaries showed polycystic changes and the body weight and the relative weight of the ovaries increased (P<0.05). The estrous cycle, polycystic ovary, body weight and relative weight of the ovaries in PLP group and Metformin group recovered significantly (P<0.05). The serum levels of TC, TG, LDL-C, HDL-C, FINS, T, LH, E2 and FSH were detected by ELISA kits. After treatment, the serum levels of TC, TG, LDL-C, FINS, T, LH and LH/FSH in the PLP group and Metformin group were lower than PCOS group (P<0.05). In addition, the serum levels of E2, FSH and HDL-C were increased (P<0.05) in the PLP group and Metformin group. The results showed that Phellinus linteus polysaccharides can ameliorate glucose and lipid metabolism, polycystic ovary and regulate the levels of sex hormones in PCOS rats.
Zhiqiang Liu,Chaojie Chong,Zhewen Dong,Yaqi Wu,Wanying Li,Haokun Chen,Shumei Zhong,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of ACP on letrozole-induced PCOS rats. All rats were divided into normal groups, PCOS group, metformin group and ACP group. The body weight (BW) was recorded every three days, and the final body weight as well as ovarian weight were recorded. Serum levels of TC, TG, HDL-C, LDL-C and E2, T, FSH and LH were measured by ELISA assay, and the LH/FSH ratio was calculated. The results showed that ACP decreased the BW and the ratio of ovarian to BW. Compared with the normal group, the serum levels of T, LH, LH/FSH, TG, TC, LDL-C increased, and the levels of FSH, E2, HDL-C decreased in PCOS group. ACP effectively improves the serum levels of FSH, LH/FSH, TG, TC, LDL-C and other related factors. The results of H&E staining of ovarian tissues showed that the ACP group showed different degrees of improvement in the reduced number of corpus luteum, thinning of granulosa cell layer, follicular capsular dilatation and follicular atresia. ACP not only reduces BW and the ratio of ovarian to BW, but also it can elevate the level of FSH and reduce LH/FSH, TG, TC and HDL-C levels. Furthermore, ACP can protect ovarian tissue to some extent.
Huan Lan,Zhewen Dong,Yaqi Wu,Chaojie Chong,Zhiqiang Liu,Wanying Li,Zixian Wang,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, we investigated the antifibrotic effects of Rha on letrozole-induced PCOS in rats. Rha treatment restored letrozole-induced alterations in the body weight (BW), relative weights of the ovaries, and relative weights of uterine and visceral adipose tissues. Histological observation showed that Rha reduced the number of atretic follicles, cystic follicles, and fibrosis of the ovaries in the PCOS rats. Administration of Rha reduced letrozole-induced metabolic dysfunction by decreasing the serum levels of TG and TC and increasing the levels of HDL-C in the PCOS rats. Rha treatment also modulated the serum levels of sex hormones, which decreased the LH, E2 and T and increased the FSH in PCOS rats. Finally, Rha treatment appeared to increase the activity of PPAR-γ, reduce the activation of the TGF-β1/Smad pathway, and reduce the collagen I, α-SMA and CTGF levels in the ovaries of the PCOS rats. Our results demonstrated that Rha significantly ameliorated metabolic disturbances and ovarian fibrosis in the letrozole-induced PCOS rats. Rha may be an effective compound in preventing ovarian fibrosis in the future.
Huan Lan,Zhewen Dong,Yaqi Wu,Chaojie Chong,Zhiqiang Liu,Wanying Li,Zixian Wang,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study investigated the antifibrotic effects of SA on ovarian fibrosis in letrozole-induced PCOS in rats. SA treatment restored letrozole-induced alterations in the body weight (BW), relative weights of the ovaries, and visceral adipose tissues. Histological observation showed that SA reduced the number of atretic follicles, cystic follicles, and fibrosis of the ovaries in PCOS rats. SA treatment also modulated the serum levels of sex hormones, which decreased the luteinizing hormone (LH), and testosterone (T) and increased the follicle-stimulating hormone (FSH) in PCOS rats. Administration of SA reduced letrozole-induced metabolic dysfunction by decreasing the serum levels of triglyceride (TG) and total cholesterol (TC) and increasing the levels of high-density lipoprotein cholesterol (HDL-C) in PCOS rats. Finally, SA treatment appeared to increase the activity of PPAR-γ, reduce the activation of the TGF-β1/Smad pathway, and reduce the collagen I, α-SMA and CTGF levels in the ovaries of the PCOS rats. Our results demonstrated that SA significantly ameliorated ovarian fibrosis and abolic disturbances in the letrozole-induced PCOS rats.