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Yang Liang Boo,Helen Siew Yean Ting,Diana Fui Sing Yap,See Guan Toh,Soo Min Lim 대한혈액학회 2019 Blood Research Vol.54 No.3
BackgroundClassical Hodgkin lymphoma (cHL) is a clinicopathologically unique, aggressive lympho-ma arising from germinal center B-cells and is one of the most curable hematological malignancies. This study aimed to determine the clinical course, treatment regimens, re-sponse rates, and survival data of patients diagnosed with cHL in a tertiary center.MethodsA retrospective review was conducted to include patients with a diagnosis of cHL from 2013 to 2017. Data of demographic and clinical characteristics, treatment regimens, and outcomes were collected and analyzed. ResultsWe recruited 94 patients with a median age of 27.0 [interquartile range (IQR), 12] years. Most of the patients were male (61.7%) and 73.4% were ethnic Malay. Nodular sclerosis was the most common histology (77.6%), followed by mixed cellularity (6.4%) and others (16%). The median follow-up time was 28.0 (IQR, 32) months. All patients received che-motherapy but only 13.8% received radiotherapy as consolidation. The doxor-ubicin-bleomycin-vinblastine-dacarbazine regimen was the most common (85.1%), fol-lowed by the escalated bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine- prednisolone-procarbazine regimen (14.9%). Following treatment, 76.1% of patients achieved complete response. The 2-year overall survival (OS) and progression-free sur-vival (PFS) of the entire cohort were 96.5% and 71.1%, respectively. The 2-year OS and PFS for advanced-stage disease were 93.9% and 62.8%, compared to 100% and 82.7% for early-stage disease, respectively (P=0.252 and P=0.052, respectively).ConclusionThis study provides insight into the clinical presentation and treatment outcomes among patients with cHL in Malaysia. A longer study duration is required to identify OS and PFS benefits and treatment-related complications for different chemotherapeutic regimens.
한우육의 육색 안정성과 지방산화에 미치는 환원력의 영향
김용선,김주용,이성기,양부근,양성운 한국동물자원과학회 2001 한국축산학회지 Vol.43 No.3
The effects of reducing ability on meat color stability and lipid oxidation in M. Longissimus and M. Semimembranosus of Hanwoo(Korean native cattle) beef were investigated. Samples were held 8 days at 1℃ and 90% RH, and then meat quality characteristics of Hanwoo beef were evaluated. Also, stability of meat color, myoglobin forms(%), lipid oxidation and reducing ability after a rapid denaturation test(30℃ during 5h) were investigated. CIE a*(redness), b*(yellowness), chroma(C*) values, oxymyoglobin and R630-R580 were significantly(p$lt;0.05) decreased during storage at 1℃ for two beef muscles. Also, reducing ability was significantly(p$lt;0.05) decreased during storage at 1℃and after a rapid denaturation test, then reducing ability had very poor stability. Two beef muscles after a rapid denaturation test had good color stability. Reducing ability negatively correlated with L* value, metmyoglobin(%), TBARS and POV, and positively correlated with a* and chroma values. Consequently, reducing ability of muscle is related to meat color stability and lipid oxidation.