Evaluation of Human Papilloma Virus Infection in Patients with Esophageal Squamous Cell Carcinoma from the Caspian Sea Area, North of Iran

Yahyapour, Yousef,Shamsi-Shahrabadi, Mahmoud,Mahmoudi, Mahmoud,Siadati, Sepideh,Shahryar, Shefaei Shahryar,Shokri-Shirvani, Javad,Mollaei, Hamid,Monavari, Seyed Hamid Reza Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Introduction: HPV has been found repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, reported detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types, and geographic regions of sample origin have been suggested as potential causes of variation. We have reported that infection of HPV DNA in ESCC tumors depends on anatomical sites of esophagus of the patients from Mazandaran, north of Iran. Materials and Methods: HPV DNA was examined in 46 upper, 69 middle and 62 lower third anatomical sites of esophageal squamous cell carcinoma specimens collected from Mazandaran province in north Iran, near the Caspian Littoral as a region with high incidence of ESCC. HPV L1 DNA was detected using Qualitative Real time PCR and MY09/MY11 primers. Results: 28.3% of upper, 29% of middle and 25.8% of lower third of ESCC samples were positive for HPV DNA. 13.6% for males and 14.1% for females were HPV positive in all samples. Conclusions: HPV infection is about one third of ESCC in this area. Findings in this study increase the possibility that HPV is involved in esophageal carcinogenesis. Further investigation with a larger sample size is necessary.

Stem Cell Tracing Through MR Molecular Imaging

Rasoul Yahyapour,Bagher Farhood,Ghazale Graily,Abolhasan Rezaeyan,Saeed Rezapoor,Hamid Abdollahi,Mohsen Cheki,Peyman Amini,Hengameh Fallah,Masoud Najafi,Elahe Motevaseli 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.3

Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.

Comparing the Seismic Behavior of Various Knee Braced Steel Frames Based on Incremental Dynamic Analysis and Development of Fragility Curves

R. Yahyapour,S.M. Seyedpoor 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

The main aim of this study is to assess the seismic behavior of various knee braced steel frames using nonlinear static and dynamic analyses. For this, structures with four diff erent types of knee braces at heights of 5, 10, 15 and 20 stories are designed through ETABS and then are three-dimensionally modeled via PERFORM 3D. Firstly, various seismic parameters including response modifi cation factor, ductility factor, defl ection amplifi cation factor and overstrength factor of the structures are compared via implementing the pushover analysis. Secondly, target models are subjected to fi ve far-fault and fi ve nearfault records. Fragility curves as well as curves obtained from the incremental dynamic analysis (IDA) are then compared, so as to determine the best type of bracing in terms of seismic performance. Benefi ting results of non-linear static analyses, top knee, x-knee, chevron knee and double knee braced frames have the best seismic performance, respectively. Likewise, using IDA results in the far-fault area, x-knee, top knee, chevron knee and double-knee braced frames demonstrate the best performance, respectively. In addition, in near-fi eld area at the height of 5 stories, the best performance is correspondingly attributed to x-knee, top-knee, chevron knee and double knee braces, respectively. However, at heights of 10, 15 and 20 stories, chevron knee, double knee, top knee and x-knee braced frames show a better performance, respectively.

Difference in the Incidences of the Most Prevalent Urologic Cancers from 2003 to 2009 in Iran

Basiri, Abbas,Shakhssalim, Nasser,Jalaly, Niloofar Yahyapour,Miri, Hamid Heidarian,Partovipour, Elham,Panahi, Mohammad Hossein Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Background: Urological cancers represent a major public problem associated with high mortality and morbidity. The pattern of these cancers varies markedly according to era, region and ethnic groups, but increasing incidence trends overall makes focused epidemiological studies important. The aim of the present study was to assess the incidence of most prevalent urological cancers in Iran from 2003 to 2009. Materials and Methods: The data for this study were obtained from the population-based Cancer Registry Center of the Iran Ministry of Health and Medical Education. Differences of mean age and age distributions of each cancer were compared between 2003 and 2009 in men and women. Results: Bladder cancer was the most common urologic cancer in both genders. The rate difference of age standardized ratio (ASR) of bladder and renal cell carcinoma in women were 1.54 and 2.01 percent per 100,000 population from 2003 to the 2009, respectively. In men, the rate difference of age standardized ratio of prostate, testis, kidney and bladder cancer was also 2.23, 1.2, 1.8 and 1.5 percent per 100,000 population from 2003 to 2009, respectively. The mean ages of patients in all cancers in both genders did not differ significantly through time (p value>0.05) but the distribution of ages of patients with bladder and prostate cancer changed significantly from 2003 to 2009 (p value<0.001). Conclusions: The results of present study suggest the general pattern and incidence of urological cancers in Iran are changing, the observed increase pointing to a need for urological cancer screening programs.

Evaluation of Human Papillomavirus Infections in Prostatic Disease: a Cross-Sectional Study in Iran

Ghasemian, Ehsan,Monavari, Seyed Hamid Reza,Irajian, Gholam Reza,Nodoshan, Mohammad Reza Jalali,Roudsari, Rouhollah Vahabpour,Yahyapour, Yousef Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: The role of inflammation in prostate diseases is suggested by the presence of inflammatory cells within the prostate in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) patients. In addition, bacterial and viral infection may lead to chronic and recurrent inflammation of the prostate. The human papillomaviruses (HPVs) are a family of sexually transmitted viruses which have been implicated in the aetiology of cervical cancer and several other malignancies. This study evaluated the frequency of HPV infection in individuals with prostatic disease in Iran. Materials and Methods: The study included formalin fixed paraffin- embedded tissue samples of 196 primary prostate cases, including 29 PCa and 167 BPH samples. HPV DNA was purified and amplified through MY09/MY11 and GP5+/GP6+ primers with nested PCR. All patients were interviewed using a questionnaire to collect demographic information. Results: Nested PCR showed that HPV DNA was found in 17.2 percent of PCa samples and 4.8 percent of BPH samples (not significant). Conclusions: Our data do not support a significant role of HPV infection in prostatic disease in Iranian patients, but demographic data indicated a probable association between presence of HPV DNA and risk of inflammation in prostate tissue which might lead to prostate carcinoma. Further studies are required to elucidate any roles of HPV infection in prostatic disease.