http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Radotinib induces high cytotoxicity in c-KIT positive acute myeloid leukemia cells
Heo, S.K.,Noh, E.K.,Kim, J.Y.,Jo, J.C.,Choi, Y.,Koh, S.,Baek, J.H.,Min, Y.J.,Kim, H. North-Holland 2017 European journal of pharmacology Vol.804 No.-
<P>Previously, we reported that radotinib, a BCR-ABL1 tyrosine kinase inhibitor, induced cytotoxicity in acute myeloid leukemia (AML) cells. However, the effects of radotinib in the subpopulation of c-KIT-positive AML cells were unclear. We observed that low-concentration radotinib had more potent cytotoxicity in c-KIT-positive cells than c-KIT-negative cells from AML patients. To address this issue, cell lines with high c-KIT expression, HEL92.1.7, and moderate c-KIT expression, H209, were selected. HEL92.1.7 cells were grouped into intermediate and high c-HIT expression populations. The cytotoxicity of radotinib against the HEL92.1.7 cell population with intermediate c-HIT expression was not different from that of the population with high c-KIT expression. When H209 cells were grouped into c-KIT expression-negative and c-HIT expression-positive populations, radotinib induced cytotoxicity in the c-KIT-positive population, but not the c-KIT-negative population. Thus, radotinib induces cytotoxicity in c-KIT-positive cells, regardless of the c-KIT expression intensity. Therefore, radotinib induces significant cytotoxicity in c-KIT-positive AML cells, suggesting that radotinib is a potential target agent for the treatment of c-KIT-positive malignancies including AML.</P>
<i>Rhodococcus aerolatus</i> sp. nov., isolated from subarctic rainwater
Hwang, C. Y.,Lee, I.,Cho, Y.,Lee, Y. M.,Baek, K.,Jung, Y.-J.,Yang, Y. Y.,Lee, T.,Rhee, T. S.,Lee, H. K. International Union of Microbiological Societies 2015 International journal of systematic and evolutiona Vol.65 No.2
<P>A Gram-stain-positive, rod-shaped and non-motile strain, designated PAMC 27367<SUP>T</SUP>, was isolated from rainwater collected on the Bering Sea. Analysis of the 16S rRNA gene sequence of the strain showed an affiliation with the genus <I>Rhodococcus</I>. Phylogenetic analyses revealed that strain PAMC 27367<SUP>T</SUP> formed a robust clade with the type strains of <I>Rhodococcus rhodnii</I>, <I>Rhodococcus aetherivorans</I> and <I>Rhodococcus ruber</I> with 16S rRNA gene sequence similarities of 96.3 %, 95.8 % and 95.5 %, respectively. Cells of the strain grew optimally at 25 °C and at pH 6.5–7.0 in the presence of 0–2 % (w/v) sea salts. The major polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylinositol mannoside and three unknown phospholipids. The major cellular fatty acids (>10 %) were iso-C<SUB>16 : 0</SUB>, C<SUB>17 : 1</SUB>ω8<I>c</I> and 10-methyl C<SUB>17 : 0</SUB>. Cell wall analysis showed that strain PAMC 27367<SUP>T</SUP> contained <I>meso</I>-diaminopimelic acid. The genomic DNA G+C content was 77.1 mol%. Based on the phylogenetic, chemotaxonomic and phenotypic data presented here, we propose a novel species with the name <I>Rhodococcus</I> <I>aerolatus</I> sp. nov., with PAMC 27367<SUP>T</SUP> ( = KCTC 29240<SUP>T</SUP> = JCM 19485<SUP>T</SUP>) as the type strain.</P>
Moon, S. Y.,Moon, C. W.,Chang, H. J.,Kim, T.,Kang, C. Y.,Choi, H. J.,Kim, J. S.,Baek, S. H.,Jang, H. W. Springer Science + Business Media 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.2
<P>Here we report comprehensive study of 2DEG at a-LAO/STO interfaces in comparison with 2DEG at crystalline LaAlO3 (c-LAO)/STO interfaces. We observe that the oxygen deficient environment during the deposition of LAO overlayer is essentially required to create 2DEG at LAO/STO interface regardless of growth temperature from 25 degrees C to 700 degrees C, indicating that the oxygen-poor condition in the system is more important than the crystallinity of LAO layer. The critical thickness (2.6 nm) of 2DEG formation at a-LAO/STO heterostructure is thicker than (1.6 nm) that at c-LAO/STO. Upon ex-situ annealing at 300 degrees C under 300 mTorr of oxygen pressure, 2DEG at a-LAO/STO interface is annihilated, while that in c-LAO/STO interface is still maintained. With combing these findings and scanning transmission electron microscope (STEM) analysis, we suggest that oxygen vacancies at the LAO surface is attributed to the origin of 2DEG formation at the LAO/STO and the crystallinity of the LAO overlayer plays a critical role in the annihilation of 2DEG at a-LAO/STO interface rather than in the formation of 2DEG. This work provides a framework to understand the importance of prohibiting the LAO surface from being oxidized for achieving thermally stable 2DEG at a-LAO/STO interface.</P>
승압형 컨버터를 이용한 인버터 TIG 용접기 역률개선에 관한 연구
백동영,김재문,안정준,김연충,원충연,민명식 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-
Average current mode controlled power factor correction technique utilizing converters operating in continuous conduction mode is applied to welding machine to improve welding performance. Due to its simplicity. the boost converter with automatic control is potentially the least expensive active line harmonics reducing current. We implemented the inverter TIG welding machine with boost converter.
Manganese does not alter the severe neurotoxicity of MPTP
Baek, S Y,Kim, Y H,Oh, S O,Lee, C-R,Yoo, C I,Lee, J H,Lee, H,Sim, C S,Park, J,Kim, J-W,Yoon, C S,Kim, Y Scientific & Medical Division,Macmillan Press 2007 Human & experimental toxicology Vol.26 No.3
<P>We utilized a mice model of Parkinsonism: (1) to evaluate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity; and (2) to evaluate whether manganese (Mn) exposure can affect MPTP-induced neurotoxicity. A 2 × 3 experimental design (MPTP ×± Mn) was as follows: SS, MPTP(-) × Mn(-); SLMn, MPTP(-) × low Mn(+); SHMn, MPTP(-) × high Mn(+); MpS, MPTP(+) × Mn(-); MpLMn, MPTP(+) × low Mn(+); MpHMn, MPTP(+) × high Mn(+). We administered MPTP (30 mg/kg per day) to male C57BL/6 mice intraperitoneally, once a day for 5 days. Subsequently, mice were treated with either 2 or 8 mg/kg of MnCl<SUB>2</SUB>.4H<SUB>2</SUB>O intraperitoneally, once a day for 3 weeks.</P><P>Blood and striatal Mn levels were elevated in the Mnexposed groups. The number of tyrosine hydroxylase (TH)-immunoreactive (ir) neurons in the substantia nigra pars compacta were decreased significantly in the MPTP-exposed groups. The densities of TH-ir axon terminals in caudate-putamen (CPU) were significantly decreased in the MPTP-treated groups. However, Mn treatment did not affect MPTP neurotoxicity. The densities of glial fibrillary acidic protein (GFAP)-ir astrocytes in the CPU or globus pallidus were significantly increased in the MPTP-treated groups. Concentrations of dopamine in the striatum were decreased significantly in the MPTP-exposed groups only, but Mn had no effect.</P>
김문석(M. S. Kim),유성초(S. C. Yu),임우영(W. Y. Lim),백종성(J. S. Baek) 한국자기학회 1992 韓國磁氣學會誌 Vol.2 No.3
Magnetic properties of grain aligned high Tc Y₁Ba₂Cu₃O_(7-y) superconductor are inverstigated. Grain-aligned superconductors have magnetic anisotropy in the Cu-O layer like single crystals. The lower critical field H_(c1). measured at the temperature range of 2 K up to 77 K, is found to be decreasing linearly as temperature goes up. Moreover, it decreaes more rapidly when the Cu-O layer is perpendicular to the external magnetic field. The temperature dependence of the magnetic susceptibility shows that the value of magnetic susceptibility, 4n X, is close to -1 at low temperature. The intra grain critical current density Jc, obtained from the Bean's critical state model, is found to be comparable to that of single crystal superconductors.
Kim, Y. C.,Choi, Y. S.,Alam, J.,Kim, Y. j.,Baek, K. J.,Koh, J.,Song, Y. W.,Chung, D. H.,Choi, Y. Springer Science + Business Media 2016 Immunologic research Vol.64 No.2
<P>Proteinase 3 (PR3) is the principal target of antineutrophil cytoplasmic autoantibodies (ANCA) associated with granulomatosis with polyangiitis. The aim of this study was to investigate whether bacterial PR3-homologous protease can induce autoantibodies to PR3 and ANCA-associated pathology in mice. Among the bacterial proteases that have greater than 30 % identity with PR3, a trypsin-like serine protease of Saccharomonospora viridis, a bacterium that causes hypersensitivity pneumonitis, was chosen. When the mice were immunized with the recombinant protease of S. viridis (SvPR), 75 % of NZBWF1 and 100 % of C57BL/6 mice developed high levels of autoantibodies to mouse PR3 (mPR3). The levels of antibodies to mPR3 had a strong positive correlation with those to SvPR. In addition, more than half of the mPR3-reactive sera (63 %) reacted to purified human PR3 (hPR3), and the levels of antibodies to hPR3 had a positive correlation with those to mPR3. The sera from the immunized mice strongly stained murine neutrophils in a C-ANCA pattern. Although granulomatous inflammation and signs of vasculitis were observed in several mice, they were attributable to the use of complete Freund's adjuvant in the immunization. Collectively, exposure to PR3-homologous bacterial protease could induce ANCA in mice, and this finding may provide a new insight into the triggering mechanisms for the production of PR3-ANCA.</P>
거세 및 도축시기가 한우 등심의 이화학적 특성에 미치는 영향
이경춘,박노형,정준,이성수,오영숙,백경훈,정근기,최창본 한국동물자원과학회 2004 한국축산학회지 Vol.46 No.2
This study was conducted to investigate changes in physico-chemical characteristics of Hanwoo carcass according to different castration and slaughtering ages. Total 75 Hanwoo calves(average 4 months old) were randomly assigned to Control(bulls), Treatment Ⅰ, Ⅱ, Ⅲ, or Ⅳ(castrated on 4, 9, 12, and 16 months of age, respectively) and slaughtered at 7, 9, 12, 16, and 28 months of age. Moisture contents in M. Longissimus dorsi of both Hanwoo bulls and steers were decreased as the slaughtering age increased. Moisture contents in all steer groups were significantly(P<0.05) lower(average 68.63%) than that in bulls(72.18%) at 28 months of age. Crude fat contents tended to increase as the slaughtering age increased. Crude fat contents in Treatment Ⅲ(castrated at 12 months of age) at 28 months of age were 10.24% which was the highest among all steer groups. Crude protein contents in M. Longissimus dorsi of Hanwoo bulls were around 23% regardless of slaughtering age. Water holding capacity(WHC) of both bulls and steers tended to increase as the animals aged. Steers showed rapid increase in WHC after 16 months of age and showed higher(78.39%) WHC than bulls(70.00%) at 28 months of age. Palmitic acid(C18:0) contents in Hanwoo bulls were increased as the slaughtering age increased(20.92→24.22%) whereas stearic acid(C18:0) contents were decreased(18.15→11.32%). Oleic acid(C18:1), a major unsaturated fatty acid, significangly(P<0.05) increased(25.59→37.90%) when slaughtering age of Hanwoo increased. Changes in fatty acid composition in Hanwoo steers were similar to those in bulls except oleic acid contents were higher and stearic acid contents were lower than bulls at 28 months of age.