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Xu, Han-Feng,Chen, Lei,Liu, Xian-Dong,Zhan, Yun-Hong,Zhang, Hui-Hui,Li, Qing,Wu, Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Renal cell carcinoma (RCC) is the most lethal of all urological cancers and tumor angiogenesis is closely related with its growth, invasion, and metastasis. Recent studies have suggested that epidermal growth factor-like domain multiple 7 (EGFL7) is overexpressed by many tumors, such as colorectal cancer and hepatocellular carcinoma; it is also correlated with progression, metastasis, and a poor prognosis. However, the role of EGFL7 in RCC is not clear. In this study, we examined how EGFL7 contributes to the growth of RCC using a co-culture system in vitro and a xenograft model in vivo. Downregulated EGFL7 expression in RCC cells affected the migration and tubule formation of HMEC-1 cells, but not their growth and apoptosis in vitro. The level of focal adhesion kinase (FAK) phosphorylation in HMEC-1 cells decreased significantly when co-cultured with 786-0/iEGFL7 cells compared with 786-0 cells. After adding rhEGFL7, the level of FAK phosphorylation in HMEC-1 cells was significantly elevated compared with phosphate-buffered saline (PBS) control. However, FAK phosphorylation was abrogated by EGFR inhibition. The average size of RCC local tumors in the 786-0/iEGFL7 group was noticeably smaller than those in the 786-0 cell group and their vascular density was also significantly decreased. These data suggest that EGFL7 has an important function in the growth of RCC by facilitating angiogenesis.
A Flexible Network Access Scheme for M2M Communications in Heterogeneous Wireless Networks
( Hui Tian ),( Wei Xie ),( Youyun Xu ),( Kui Xu ),( Peng Han ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.10
In this paper, we deal with the problem of M2M gateways` network selection for different types of M2M traffic in heterogeneous wireless networks. Based on the difference in traffic`s quality of service (QoS) requirements, the M2M traffic produced by various applications is mainly classified as two categories: flexible traffic and rigid traffic. Then, game theory is adopted to solve the problem of network-channel selection with the coexistence of flexible and rigid traffic, named as flexible network access (FNA). We prove the formulated discrete game is a potential game. The existence and feasibility of the Nash equilibrium (NE) of the proposed game are also analyzed. Then, an iterative algorithm based on optimal reaction criterion and a distributed algorithm with limited feedback based on learning automata are presented to obtain the NE of the proposed game. In simulations, the proposed iterative algorithm can achieve a near optimal sum utility of whole network with low complexity compared to the exhaustive search. In addition, the simulation results show that our proposed algorithms outperform existing methods in terms of sum utility and load balance.
Hui-Ru Xu,Ping-Yuan Lee,Ya-Wei Tsai,Ying-Chieh Lee 한양대학교 세라믹연구소 2021 Journal of Ceramic Processing Research Vol.22 No.2
Titanium dioxide thin films with silver dopant (Ag-TiO2) were successfully prepared on glass substrates using the thermaloxidation method. Ag-doped titanium films were prepared using direct current (DC) and radio frequency (RF) magnetron cosputteringsystems. The thermal oxidation temperature and Ag content effects on the phase evolution, microstructure, andphoto catalytic activity of TiO2 film were studied. The crystalline structures and photo catalytic activity of the annealed AgdopedTiO2 films were methodically investigated using transmission electron microscopy (TEM), field emission scanningelectron microscopy (FESEM), X-ray diffraction (XRD), and ultraviolet spectrophotometry. The results exhibited that thethermal oxidation process at 550 oC clearly caused rutile phase formation in the 2.7% Ag-doped TiO2 films directly affectingthe photo catalytic activity. The Ag-doped TiO2 films showed good photo catalytic activity under UV-light radiation, with 59%methylene blue dye degradation rate.
Hui Xu,Yichun Zhang,Bin Rong 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.3
In this study, a combination of experiments and fi nite element analyses was conducted to investigate the eff ect of initial imperfections on the axial compression of the 7A04-T6 aluminum alloy columns. Prior to the loading tests, measurement of the initial geometric imperfections for the columns were performed by optical theodolite and vernier calipert. The failure modes of 10 extruded circular columns were investigated. Meanwhile, the ultimate strengths, defl ections and surface strains in whole process under axial compression were recorded. The fi nite element (FE) models of the tested columns were developed using the non-linear fi nite element analysis (FEA) software ABAQUS, and the imperfections and material nonlinearities were considered in the FE models. The validation of the FE models was performed against the test results; it was observed that the proposed FE models are suffi ciently accurate to predict the ultimate strengths and buckling behaviors of the tested columns.
Xu, Xin-Fang,Gao, Yan,Xu, Shu-Ya,Liu, Huan,Xue, Xue,Zhang, Ying,Zhang, Hui,Liu, Meng-Nan,Xiong, Hui,Lin, Rui-Chao,Li, Xiang-Ri The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Background: Temperature is an essential condition in red ginseng processing. The pharmacological activities of red ginseng under different steam temperatures are significantly different. Methods: In this study, an ultrahigh-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry was developed to distinguish the red ginseng products that were steamed at high and low temperatures. Multivariate statistical analyses such as principal component analysis and supervised orthogonal partial least squared discrimination analysis were used to determine the influential components of the different samples. Results: The results showed that different steamed red ginseng samples can be identified, and the characteristic components were 20-gluco-ginsenoside Rf, ginsenoside Re, ginsenoside Rg1, and malonyl-ginsenoside Rb1 in red ginseng steamed at low temperature. Meanwhile, the characteristic components in red ginseng steamed at high temperature were 20R-ginsenoside Rs3 and ginsenoside Rs4. Polar ginsenosides were abundant in red ginseng steamed at low temperature, whereas higher levels of less polar ginsenosides were detected in red ginseng steamed at high temperature. Conclusion: This study makes the first time that differences between red ginseng steamed under different temperatures and their ginsenosides transformation have been observed systematically at the chemistry level. The results suggested that the identified chemical markers can be used to illustrate the transformation of ginsenosides in red ginseng processing.