http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effects of Gate-Pulse Shape on the Accuracy of Charge-Pumping Measurement
Lai,P. T.,Xu,J. P.,Xu,C. K. Poek,ChEng,Y. C. 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1
Charge-pumping (CP) measurement is performed on MOSFETs with their gates tied to sawtooth pulses. Influence of both rise time (t_r) and fall time (t_f) on CP current is investigated. Results show that the dominant mechanism affecting the measurement accuracy is the energy range of interface-trap distribution D_(it)(E) swept by the gate signal for low frequencies and carrier emissions for high frequencies. Hence, it is suggested that low frequency is more favorable than high frequency, especially for sawtooth pulses with long t_r and short t_f, due to little carrier emission and negligible geometric effects. Thus, the optimum frequency and corresponding t_r/t_f of the sawtooth pulses are determined to be about 100 kHz and 9/1 ㎲ which can be used to accurately estimate the density of interface states in MOSFETs.
( Lai Wei ),( Mingxiang Zhang ),( Min Xu ),( Wan-Long Chuang ),( Wei Lu ),( Wen Xie ),( Zhansheng Jia ),( Guozhong Gong ),( Yueqi Li ),( Si Hyun Bae ),( Yong-Feng Yang ),( Qing Xie ),( Shumei Lin ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The efficacy/safety of daclatasvir (pan-genotypic NS5A inhibitor) plus asunaprevir (NS3 protease inhibitor) in interferon (± ribavirin)- ineligible/intolerant patients with chronic HCV genotype-1b infection from mainland China, Korea and Taiwan was investigated in a phase 3, open-label study. Methods: Patients received daclatasvir 60 mg (tablet) once daily plus asunaprevir 100 mg (soft capsule) twice daily for 24 weeks. The primary endpoint was sustained virologic response at post-treatment Week 24 (SVR24). Results: This study treated 159 patients from mainland China (80%), Korea (11%) and Taiwan (9%), including patients with cirrhosis (33%), IL28B non-CC genotypes (40%), and aged ≥70 years (4%). SVR24 was achieved by 91% of patients (100% concordance with SVR12) and was similarly high in all subgroups, e.g. cirrhotic patients (90%), and in patients from mainland China (91%), Korea (94%) and Taiwan (87%). SVR24 was higher in patients without baseline NS5A (L31M/Y93H) resistance-associated variants (RAVs) (n=137/139 [99%]), regardless of the presence (98%) or absence (99%) of cirrhosis, and lower in patients with baseline NS5A RAVs (n=8/19 [42%]). All serious adverse events (AEs) (n=5/159 [3.1%]), grade 4 laboratory abnormalities (n=3/159 [1.9%]) and deaths (n=1/159 [0.6%]) that occurred on-treatment were unrelated to the study drugs; two patients discontinued due to AEs. Treatment was generally well tolerated regardless of cirrhosis status. Conclusions: Daclatasvir plus asunaprevir achieved a high SVR24 rate of 91%, rising to 99% in patients without baseline NS5A RAVs, and was generally well tolerated in cirrhotic and non-cirrhotic interferon (± ribavirin)-ineligible/intolerant patients with HCV genotype-1b infection from mainland China, Korea and Taiwan.
Lai, Jing,Yang, Fang,Zhang, Wenwen,Wang, Yanru,Xu, Jing,Song, Wei,Huang, Guichun,Gu, Jun,Guan, Xiaoxiang Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.8
The p73 gene contains an extrinsic P1 promoter and an intrinsic P2 promoter, controlling the transcription of the pro-apoptotic TAp73 isoform and the anti-apoptotic ${\Delta}Np73$ isoform, respectively. The DNA methylation status of both promoters act equally in the epigenetic transcriptional regulation of their relevant isoforms. The aim of this study was to analyze the different effects of these p73 isoforms in 5-aza-2'-deoxycytidine (5-aza-dC)-induced apoptosis in breast cancer cells. We investigated the effects of the DNA demethylation agent, 5-aza-dC, on the T-47D breast cancer cell line, and evaluated the methylation status of the p73 promoters and expression of TAp73 and ${\Delta}Np73$. Furthermore, we assessed the expression of p53 and p73 isoforms in 5-aza-dC-treated T-47D cells and p53 knockout cells. 5-aza-dC induced significant anti-tumor effects in T-47D cells, including inhibition of cell viability, G1 phase arrest and apoptosis. This was associated with p73 promoter demethylation and a concomitant increase in TAp73 mRNA and protein expression. In contrast, the methylation status of promoter P2 was not associated with ${\Delta}Np73$ mRNA or protein levels. Furthermore, demethylation of P2 failed to inhibit the expression of ${\Delta}Np73$ with 5-aza-dC in the p53 knockdown cell model. Our study suggests that demethylation of the P1 and P2 promoters has opposite effects on the expression of p73 isoforms, namely up-regulation of TAp73 and down-regulation of ${\Delta}Np73$. We also demonstrate that p53 likely contributes to 5-aza-dC-induced ${\Delta}Np73$ transcriptional inactivation in breast cancer cells.
ON FP-FILTERS AND FPD-FILTERS OF LATTICE IMPLICATION ALGEBRA
Lai, Jiajun,Xu, Yang,Chang, Zhiyan Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.3-4
In this paper, we consider the fuzzification of prime filters in Lattice Implication Algebras (briefly, LIAs), and introduce the concepts of fuzzy prime filters (briefly, FP-filters), and we also studied the properties of FP-filters. Finally, we investigate the properties of fuzzy prime dual filters (briefly, FPD-filters) in LIA, and the relations of them are investigated.
Pimecrolimus increases the melanogenesis and migration of melanocytes in vitro
Xu, Ping,Chen, Jie,Tan, Cheng,Lai, Ren-Sheng,Min, Zhong-Sheng The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, $10^2$nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, $10^2$ and $10^3nM$ significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to $10^2$nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at $10^2nM$. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.
A NOVEL TECHNIQUE OF N2O-TREATMENT ON NH3-NITRIDED OXIDE FOR FABRICATING GATE OXIDE IN NMOSFET`S
Xu,ZEng,Lai,P. T.,Ng,W. T. 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
a new technique of N₂O treatment on NH₃-nitrided oxide is used to prepare thin gate oxide. Experiments on MOS capacitors and nMOSFET's shows that N₂O treatment is superior to conventional reoxidation step in suppressing electron trapping and interface trap creation under high-field stress.
On FP-filters and FPD-filters of lattice implication algebra
Jiajun Lai,Yang Xu,Zhiyan Chang 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.3-4
In this paper, we consider the fuzzification of prime filters in Lattice Implication Algebras (briefly, LIAs), and introduce the concepts of fuzzy prime filters (briefly, FP-filters), and we also studied the properties of FP-filters. Finally, we investigate the properties of fuzzy prime dual filters (briefly, FPD-filters) in LIA, and the relations of them are investigated.