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        Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury

        Xintao Huang,Dahai Wan,Yunpeng Lin,Naizhao Xue,Jiehe Hao,Ning Ma,Xile Pei,Ruilong Li,Wenju Zhang 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.5

        Purpose: Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown that infusion of human umbilical cord blood-derived endothelial colony-forming cells improves outcomes in mice subjected to experimentaltraumatic brain injury (TBI). However, the efficiency of cell transplantation is not satisfactory. Oxidative stress plays a significant role in the survival of transplanted cells following ischemic reperfusion injury. This observational clinical study investigatedthe correlation between the number of circulating EPCs and plasma levels of superoxide dismutase (SOD) and malonyldialdehyde(MDA). Materials and Methods: Peripheral blood samples were collected from 20 patients with mild TBI at day-1, day-2, day-3, day-4, and day-7 post TBI. The number of circulating EPCs and the plasma levels of SOD and MDA were measured. Results: The average of circulating EPCs in TBI patients decreased initially, but increased thereafter, compared with healthy controls. Plasma levels of SOD in TBI patients were significantly lower than those in healthy controls at day-4 post-TBI. MDA levels showed no difference between the two groups. Furthermore, when assessed on day-7 post-TBI, the circulating EPC number were correlated with the plasma levels of SOD and MDA. Conclusion: These results suggest that the number of circulating EPCs is weakly to moderately correlated with plasma levels of SOD and MDA at day-7 post-TBI, which may offer a novel antioxidant strategy for EPCs transplantation after TBI.

      • Blind Separation of Tampered Image Based on JPEG Double Quantization Effect

        Duan Xintao,Peng Tao,Huang Jingjing,Li feifei,Wang Jingjuan 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.11

        The double quantization effect of JPEG provides important clue for detecting image tampering. Whenever an original JPEG image has undergone a localized tampering and saved in JPEG again, the DCT coefficients of the areas without tampering will be compressed for twice while the tampered areas only suffered once. The Alternating Current (AC) coefficient distribution accord with a Laplace probability density distribution described with parameter. This paper proposed a new double compression probability model of JPEG image to describe the change of DCT coefficients’ statistical properties after the double compression. According to Bayes’ theorem, using the posterior probability, the model can also show the eigenvalues of the double and single compressed block. We assign a dynamic adaptive threshold for the eigenvalues with the Particle Swarm Optimization Algorithm. Then the tampered region is detected and separated automatically by using the threshold. The experimental results show that the method can detect and separate the tamped area effectively and it outperforms other algorithms in terms of the detection result especially when the second compression factor is smaller than the first one. Compared with other traditional methods, the proposed approach could effectively separate the tampered regions from the tampered image without respect to the location, size and number of tampered images.

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