Solvent-free aerobic oxidation of ethylbenzene over Mn-containing silylated MgAl layered double hydroxides

Lei Yang,Binbin Fan,Xingyu Cui,Xiufeng Shi,Ruifeng Li 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

A novel method for the preparation of Mn-containing silylated layered double hydroxides (LDHs) ispresented. The method involves functionalizing the calcined MgAl LDH (LDO) with dimethoxydiphenylsilane(DDS), and then treating it in the aqueous solution of KMnO4 under Ar. The prepared Mncontainingsilylated MgAl LDH catalysts have higher Mn amount and more accessible Mn sites than thecorresponding Mn-containing MgAl LDH catalysts, and exhibited much higher catalytic activity in theoxidation of ethylbenzene with O2 in the absence of organic solvents than the latter. In addition, theprepared Mn-containing silylated MgAl LDH catalyst was highly stable and reusable.

Analysis of Load Characteristic and Contact Patch Characteristic of Support Insert Run-Flat Tire under Zero-Pressure Condition

Zang Liguo,Wang Xingyu,Wu Chongyou,Teng Fei,Shaoqing Yang 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.5

Support insert run-flat tire is a kind of safety tire based on common tire structure. It has the advantages of simple structure, easy disassembly and strong bearing capacity. However, when driving under zero-pressure condition, it can not meet the requirements of heavy load, high mobility and long-distance. Aiming at this problem, the finite element model is established. The load and contact patch characteristics of the model are simulated by ABAQUS. The radial stiffness curve and the contact pressure distribution under zero-pressure are obtained. The results show that the radial stiffness curve presents a certain nonlinearity in the sidewall loading stage. When the insert contacts the tire, it is approximately linear. The contact pressure distribution cloud diagram under zero-pressure condition shows that there is warpage. The tire test bench was set up and the relevant test scheme was formulated. The radial stiffness curve and the footprint of the support insert run-flat tire under zeropressure condition were obtained. The research results show that the simulation and test results are in good agreement. This research is of great significance to the performance analysis of whole support insert run-flat tire under zero- pressure condition.

The complete mitochondrial genome of Nephrotoma scalaris parvinotata (Brunetti 1918) (Diptera: Tipulidae) and insights into the phylogeny of Tipulomorpha

Song Nan,Wu Qiong,Lin Xingyu,Zhang Yang,Zhao Te 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

Craneflies (Tipuloidea or Tipulidae sensu lato) are one of the most diverse groups of true flies (Insecta, Diptera). The Tipuloidea and perhaps the Trichoceridae formed the infraorder Tipulomorpha, which is traditionally considered the most basal group of Diptera. Relationships among Tipulomorpha and the phylogenetic position of this infraorder within the whole Diptera remain to be settled. A mitochondrial genome (mitogenome) phylogeny of Diptera was produced to test the relationships within Tipulomorpha and its phylogenetic position. A complete mitogenome of Nephrotoma scalaris parvinotata (Tipuloidea, Tipulidae) was firstly sequenced with a nextgeneration sequencing approach. Compared with the published mitogenomes of Tipuloidea, the new mitoge nome had a larger genome size (17,862 nt), due to a longer non-coding control region. The gene order was identical to Drosophila yakuba. Phylogenetic reconstructions using different inference methods recovered Tipu lomorpha as monophyletic. And the Tipulomorpha was retrieved in a relatively basal position in Diptera. Within Tipulomorpha, the Tipuloidea and the Trichoceridae were strongly supported as reciprocally monophyletic. Relationships within Tipuloidea were resolved as (Pedicidae + (Limoniidae + (Cylindrotomidae + Tipulidae))). Well supported relationships include: Pedicidae was the sister group of (Limoniidae + (Tipulidae + Cylin drotomidae)); Limoniidae was paraphyletic with respect to (Tipulidae + Cylindrotomidae); Cylindrotomidae was the sister group of Tipulidae. The newly sequenced N. scalaris parvinotata clustered with other two Nephrotoma species at a derived position in Tipuloidea.

Computational Studies on Mesh Stiffness of Paralleled Helical Beveloid Gear Pair

Ruihua Sun,Chaosheng Song,Caichao Zhu,Yawen Wang,Xingyu Yang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.1

Considering the asymmetrical left and right tooth profiles including the transient curve at the tooth root region and the varying thickness along the axial direction due to the cone angle, we build the accurate profile curve model including the transient curve at the tooth root of helical beveloid gear with machining parameters to solve the problem of non-applicability of real digital model. According to the feature of gear shape varying along tooth width direction, we introduced the slicing method and derived its grouping formula. Finally, the efficient and accurate slicing-based mesh stiff ness calculation model of paralleled helical beveloid gears was proposed using potential energy theory. Then, mesh stiff ness was calculated using finite element contact model for comparison and verification. Finally, the impacts of macro geometry parameters including cone angle, normal pressure angle, helix angle, tooth width and addendum coefficient on single and total mesh stiff ness were analyzed. The calculated mesh stiff ness correlates well with the results from FEM with the maximum peak error is 4.8%. Results show that the tooth width shows an obvious incremental impact on average total mesh stiff ness. When the pressure angle, helix angle, cone angle and addendum coefficient increase, the average total mesh stiff ness increases first and then decreases. For the fluctuating value, it increases as the tooth width, helix angle and cone angle increase. However, the pressure angle and addendum coefficient show an opposite impact on the fluctuating value.

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.

Gestational weight gain of multiparas and risk of primary preeclampsia: a retrospective cohort study in Shanghai

Chen Chao,Lei Zhijun,Xiong Yaoxi,Ni Meng,He Biwei,Gao Jing,Zheng Panchan,Xie Xianjing,He Chengrong,Yang Xingyu,Cheng Weiwei 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-

Background In all studies conducted so far, there was no report about the correlation between excessive gestational weight gain (GWG) and the risk of preeclampsia (PE) in multiparas, especially considering that multiparity is a protective factor for both excessive GWG and PE. Thus, the aim of this retrospective cohort study was to determine whether GWG of multiparas is associated with the increased risk of PE. Methods This was a study with 15,541 multiparous women who delivered in a maternity hospital in Shanghai from 2017 to 2021, stratifed by early-pregnancy body mass index (BMI) category. Early-pregnancy body weight, height, week-specifc and total gestational weight gain as well as records of antenatal care were extracted using electronic medical records, and antenatal weight gain measurements were standardized into gestational age-specifc z scores. Results Among these 15,541 multiparous women, 534 (3.44%) developed preeclampsia. The odds of preeclampsia increased by 26% with every 1 z score increase in pregnancy weight gain among normal weight women and by 41% among overweight or obese women. For normal weight women, pregnant women with preeclampsia gained more weight than pregnant women without preeclampsia beginning at 25 weeks of gestation, while accelerated weight gain was more obvious in overweight or obese women after 25 weeks of gestation. Conclusions In conclusion, excessive GWG in normal weight and overweight or obese multiparas was strongly associated with the increased risk of preeclampsia. In parallel, the appropriate management and control of weight gain, especially in the second and third trimesters, may lower the risk of developing preeclampsia.