SIMULATION AND OPTIMIZATION METHODS OF THE THERMAL CONTROL LOOP OF SPACECRAFT

Xin Gang Liang,Qun Chen,Xiang Hua Xu 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.5

Power consumption keeps increasing with increase in their functions and capabilities of spacecraft, which in turn results in the requirement of thermal control techniques, efficient that dissipation and thermal management. The numerical simulation of the thermal control loop should be performed before and after its design and ground test of the thermal control and management is necessary to measure their reliability. A semi-physical ground test method for the thermal control loop of space station is proposed which can realize dynamic measurement of the thermal control loop. A method of simplifying the numerical simulation of the thermal control loop is developed and a new technique, the heat flow circuit, is induced for the numerical simulation and optimization of the thermal control loop.

Anisotropic Thermal Conductance in Thin Layers of Disordered Packed Spheres

Xin Gang Liang,Jennifer R. Lukes,Chang Lin Tien 대한기계학회 1998 Heat transter conference Vol.7 No.1

The NADPH oxidase AoNoxA in Arthrobotrys oligospora functions as an initial factor in the infection of Caenorhabditis elegans

Xin Li,Ying-Qian Kang,Yan-Lu Luo,Ke Qin Zhang,Cheng-Gang Zou,Lian-Ming Liang 한국미생물학회 2017 The journal of microbiology Vol.55 No.11

Reactive oxygen species (ROS) produced by NADPH oxidases can serve as signaling molecules to regulate a variety of physiological processes in multi-cellular organisms. In the nematophagous fungus Arthrobotrys oligospora, we found that ROS were produced during conidial germination, hyphal extension, and trap formation in the presence of nematodes. Generation of an AoNoxA knockout strain demonstrated the crucial role of NADPH oxidase in the production of ROS in A. oligospora, with trap formation impaired in the AoNoxA mutant, even in the presence of the nematode host. In addition, the expression of virulence factor serine protease P186 was up-regulated in the wild-type strain, but not in the mutant strain, in the presence of Caenorhabditis elegans. These results indicate that ROS derived from AoNoxA are essential for full virulence of A. oligospora in nematodes.

Study on Mechanical Properties of Press-Bending Members Based on Transmission Towers Diagonal Member Reinforcement In-Situ

Zhenke Xin,Huanhuan Wei,Yunhe Liu,Gang Liang 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.4

According to the reinforcement requirements of load-bearing members of existing transmission tower, a new type of in-situ reinforcement scheme for the angle steel T-shaped composite section is proposed. Through the compression test of 10 groups of members, the infl uence of slenderness ratio, the number of fi xtures, the number of bolt rows and other parameters on the failure mode and bearing performance of members was studied. A simulation model was established using ABAQUS software, the load-displacement curve, failure models and other aspects verify the reliability and validity of simulation results. The results show that when the slenderness ratio of member reaches a certain value, the ultimate bearing capacity of member reinforced with the reinforcement angle steel of same specifi cation and strength can be multiplied and increased several times, the slenderness ratio has little eff ect on the force transmission effi ciency of reinforcement angle steel. The number of bolt rows has a small eff ect on the ultimate bearing capacity of member, the increase rate of ultimate bearing capacity, the failure mode and the force transmission effi ciency of reinforcement angle steel, the infl uence of strength of reinforcement angle steel, the specifi cation of reinforcement angle steel on the ultimate bearing capacity, and the increase rate of ultimate bearing capacity of member obviously, the higher strength and specifi cation of reinforcement, the greater the ultimate bearing capacity of reinforced member, and the higher the rate of improvement of ultimate bearing capacity, the smaller the thickness of fi ller plate, that is the smaller the eccentricity, the higher force transmission effi ciency of reinforcement. The research results can provide experimental and theoretical basis for the reinforcement of tower structure and engineering design.

Is Folate Status a Risk Factor for Asthma or Other Allergic Diseases?

Ting Wang,Zong-An Liang,Yu-Lin Ji,Hong-Ping Zhang,Xin Zhang,Gang Wang 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.6

Purpose: It is controversial whether folate status is a risk factor for the development of asthma or other allergic diseases. This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Methods: Electronic databases were searched to identify all studies assessing the association between folate status and asthma or other allergic diseases. Two reviewers independently assessed the eligibility of studies and extracted data. The relative risk (RR) or odds ratio (OR) with 95% confidence intervals (CI) was calculated and pooled. Results: Twenty-six studies (16 cohort, 7 case-control, and 3 cross-sectional studies) were identified. Maternal folic acid supplementation was not associated with the development of asthma, atopic dermatitis (AD), eczema, and sensitization in the offspring, whereas exposure during early pregnancy was related to wheeze occurrence in the offspring (RR=1.06, 95% CI=[1.02-1.09]). The TT genotype of MTHFR C677T polymorphism was at high risk of asthma (OR=1.41, 95% CI=[1.07-1.86]). Conclusions: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development. These results might provide additional information for recommendations regarding forced folate consumption or folic acid supplements during pregnancy based on its well-established benefits for the prevention of congenital malformations. However, currently available evidence is of low quality which is needed to further elucidate.

Relation between Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α Expression in Invasive Ductal Breast Cancer Patients and Correlations with Prognosis

Yan, Jian,Liu, Xiao-Long,Han, Lu-Zhe,Xiao, Gang,Li, Ning-Lei,Deng, Yi-Nan,Yin, Liang-Chun,Ling, Li-Juan,Yu, Xiao-Yuan,Tan, Can-Liang,Huang, Xiao-Ping,Liu, Li-Xin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

The aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-${\alpha}$ in the tumor tissue of patients with invasive ductal carcinoma(IDC); in addition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who were not previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Follow-up data were collected for 3 months to 10 years and analyzed for tumor recurrence, survival time, and prognostic risk factors. We determined Ki-67 expression correlates with the expression of ER, PR, HER-2, EGFR, and TOP-${\alpha}$, as well as lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in IDC. Positive Ki-67 expression was a risk factor for rapid tumor recurrence and may help tumor progression, leading to poor prognosis in IDC. Ki-67 was directly correlated with EGFR, TOP II-${\alpha}$, lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in the hormone receptor subtypes of breast cancer. In triple negative breast cancer, Ki-67 correlated with TOP II-${\alpha}$. Expression of Ki-67 correlated with that of ER, PR, HER-2, EGFR, TOP II-${\alpha}$, and p21. In addition, the biomarker Ki-67 has a role as a prognostic factor and indicates a poor prognosis in IDC.