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Injectable In situ Forming Chitosan-Based Hydrogels For Curcumin Delivery
Titima Songkroh,Xiaojun Ma,Hongguo Xie,Weiting Yu,Xiudong Liu,Guangwei Sun,Xiaoxi Xu 한국고분자학회 2015 Macromolecular Research Vol.23 No.1
In this paper, a series of injectable in situ forming chitosan-based hydrogels were prepared by chemicalcrosslinking of chitosan and genipin with the cooperation of ionic bonds between chitosan and sodium salts at roomtemperature. Four hydrogels (A, B, C, and D) were obtained by mixing chitosan, genipin and a sodium salt of trisodiumphosphate (Na3PO4·12H2O), sodium sulfate (Na2SO4), sodium sulfite (Na2SO3), or sodium bicarbonate (NaHCO3)and examined for their characteristics, morphology, and rheological properties. Their cell viability assaysexhibited low toxicity and the localized in situ gel formation was detected after subcutaneous injections in rat. Curcuminwhich possesses many pharmaceutical potentials but has low bioavailability, was chosen as a drug model. Invitro curcumin release profiles exhibit sustained release properties with initial burst release for all hydrogels withabout 3 to 6 times higher cumulative release than other gel controls. The results of this study demonstrate that ourhydrogels have a potential as local curcumin carriers.