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XiaoWei Song,Yong Ji Yang,Ya Feng Shen,Mi Cao,QingNing Yuan,Ying Tang,Changhai Lei 한국통합생물학회 2014 Animal cells and systems Vol.18 No.3
Acute myocardial infarction remains one of the leading causes of death and disability worldwide. Themechanisms underlying myocardial infarction involve a complex of signaling molecules, such as tumornecrosis factor α (TNFα), interleukin-6 (IL6), C-Myc, atria natriuretic peptide (ANP), superoxide dismutase1 (SOD1), and so on. The aim of this study is to understand the time-dependent expressional pattern of theseearly responsible genes following acute myocardial ischemia established by left anterior descending (LAD)coronary artery ligation. After LAD ligation, a collection of genes was detected using real-time polymerasechain reaction (PCR). The expression of inflammation-related genes, such as TNFα and IL6, was immediatelyupregulated at 2 h, reached to the highest point at 12 h, and then decreased to nearly basis level at 24 h afterligation, suggesting inflammation appeared and disappeared rapidly after acute ischemia. C-Myc, an importanttranscription factor, was significantly upregulated at 2 h, and thereafter persisted at high level to 24 h. Thesecretary peptide, ANP, was consistently upregulated from 2 to 24 h, reached to 40-folds at 24 h. The calciumregulatedgene, FK506-binding protein 12.6, was not significantly altered after ischemia. SOD1 was not alteredat the first 4 h, and began to downregulate at 12 and 24 h. These results indicate that several genes weredynamically and transiently regulated after acute myocardial infarction (AMI) in a time-dependent pattern,suggesting that there is an immediate molecular response to acute myocardial ischemia, which might provideus a new insight to understand molecular mechanisms of AMI.
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Epidemiological Characteristics of Norovirus Outbreaks in Shenyang from 2017 to 2021
Qi Ying,Dong Xinxin,Cheng Xiaowei,Xu Han,Wang Jin,Wang Bing,Chen Ye,Sun Baijun,Zhang Linlin,Yao Yan 한국미생물학회 2023 The journal of microbiology Vol.61 No.4
Norovirus is one of the leading causes of acute gastroenteritis outbreaks worldwide. This study aimed to identify the epidemiological characteristics of norovirus outbreaks and to provide evidence for public health entities. Specimens and epidemiological survey data were collected to determine if there were differences in the attack rate of norovirus in terms of the year, season, transmission route, exposure setting, and region and to determine whether there were relationships between the reporting interval, the number of illnesses in a single outbreak and the duration of the outbreak. Norovirus outbreaks were reported throughout the year, with seasonal characteristics (i.e., high rates in spring and winter). Among all regions in Shenyang with the exception of Huanggu and Liaozhong, norovirus outbreaks had been reported, and the primary genotype was GII.2[P16]. Vomiting was the most common symptom. The main places of occurrence were childcare institutions and schools. The person-to-person route was the main transmission route. The median duration of norovirus was 3 days (IQR [interquartile range]: 2–6 days), the median reporting interval was 2 days (IQR: 1–4 days), the median number of illnesses in a single outbreak was 16 (IQR: 10–25); there was a positive correlation between these parameters. Norovirus surveillance and genotyping studies still need to be further strengthened to increase knowledge regarding the pathogens and their variant characteristics, to better characterize the patterns of norovirus outbreaks and to provide information for outbreak prevention. Norovirus outbreaks should be detected, reported and handled early. Public health entities and the government should develop corresponding measures for different seasons, transmission routes, exposure settings, and regions.
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Limiting Attribute Disclosure in Randomization Based Microdata Release
Guo, Ling,Ying, Xiaowei,Wu, Xintao Korean Institute of Information Scientists and Eng 2011 Journal of Computing Science and Engineering Vol.5 No.3
Privacy preserving microdata publication has received wide attention. In this paper, we investigate the randomization approach and focus on attribute disclosure under linking attacks. We give efficient solutions to determine optimal distortion parameters, such that we can maximize utility preservation while still satisfying privacy requirements. We compare our randomization approach with l-diversity and anatomy in terms of utility preservation (under the same privacy requirements) from three aspects (reconstructed distributions, accuracy of answering queries, and preservation of correlations). Our empirical results show that randomization incurs significantly smaller utility loss.
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MiR-212 Attenuates MPP+-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells
Yanfeng Song,Ying Liu,Xiaowei Chen 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.3
Purpose: Parkinson’s disease (PD) is a common age-dependent neurodegenerative disease. MiR-212 has been demonstrated toexert protective effects in several neurological disorders. The present study aimed to investigate the role and underlying molecularmechanism of miR-212 in PD. Materials and Methods: 1-methyl-4-phenylpyridinium (MPP+)-induced SH-SY5Y cells were applied as a PD model in vitro. RTqPCRwas used to measure the expression of miR-212 and Kruppel-like factor 4 (KLF4) mRNA. Western blot analysis was performedto detect the protein levels of KLF4, Notch1 and Jagged1. Cell viability and apoptosis were determined by the Cell CountingKit-8 and flow cytometry, respectively. Quantitative analysis of caspase-3 activity, lactate dehydrogenase (LDH), reactiveoxygen species (ROS), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) was conductedwith corresponding ELISA kits. Dual-luciferase reporter assay was employed to evaluate the relationship between miR-212 and KLF4. Results: MiR-212 was downregulated in MPP+-induced SH-SY5Y cells. Also, miR-212 alleviated MPP+-induced SH-SY5Y cell damage,embodied by increased cell viability, decreased caspase-3 activity, LDH release, ROS production, TNF-α, and IL-1β expression,as well as elevated SOD levels. KLF4 was a direct target of miR-212, and miR-212 repressed KLF4 expression in a post-transcriptionalmanner. Moreover, miR-212-mediated protection effects were abated following KLF4 expression restoration in MPP+-induced SH-SY5Y cells, represented as lowered cell viability and enhanced apoptotic rate. Furthermore, Notch signaling wasinvolved in the regulation of miR-212/KLF4 axis in MPP+-induced SH-SY5Y cells. Conclusion: miR-212 might attenuate MPP+-induced neuronal damage by regulating KLF4/Notch signaling pathway in SH-SY5Ycells, a promising target for PD therapy.
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Limiting Attribute Disclosure in Randomization Based Microdata Release
Ling Guo,Xiaowei Ying,Xintao Wu 한국정보과학회 2011 Journal of Computing Science and Engineering Vol.5 No.3
Privacy preserving microdata publication has received wide attention. In this paper, we investigate the randomization approach and focus on attribute disclosure under linking attacks. We give efficient solutions to determine optimal distortion parameters, such that we can maximize utility preservation while still satisfying privacy requirements. We compare our randomization approach with i-diversity and anatomy in terms of utility preservation (under the same privacy requirements) from three aspects (reconstructed distributions, accuracy of answering queries, and preservation of correlations). Our empirical results show that randomization incurs significantly smaller utility loss.
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