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Opto-VLSI-based tunable single-mode fiber laser
Xiao, Feng,Alameh, Kamal,Lee, TongTak The Optical Society 2009 Optics express Vol.17 No.21
<P>A new tunable fiber ring laser structure employing an Opto-VLSI processor and an erbium-doped fiber amplifier (EDFA) is reported. The Opto-VLSI processor is able to dynamically select and couple a waveband from the gain spectrum of the EDFA into a fiber ring, leading to a narrow-linewidth high-quality tunable laser output. Experimental results demonstrate a tunable fiber laser of linewidth 0.05 nm and centre wavelength tuned over the C-band with a 0.05 nm step. The measured side mode suppression ratio (SMSR) is greater than 35 dB and the laser output power uniformity is better than 0.25 dB. The laser output is very stable at room temperature.</P>
Xiao, Feng,Yoo, Bongyoung,Lee, Kyu-Hwan,Myung, Nosang V IOP Pub 2007 Nanotechnology Vol.18 No.33
<P>A wide range of (Bi<SUB>1−<I>x</I></SUB>Sb<SUB><I>x</I></SUB>)<SUB>2</SUB>Te<SUB>3</SUB> thin films and nanowires were electrodeposited from acidic tartaric–nitric baths. Initially, (Bi<SUB>1−<I>x</I></SUB>Sb<SUB><I>x</I></SUB>)<SUB>2</SUB>Te<SUB>3</SUB> thin films were electrodeposited on gold substrates to investigate the effect of the deposition potential and electrolyte composition on film composition. After these investigations, (Bi<SUB>1−<I>x</I></SUB>Sb<SUB><I>x</I></SUB>)<SUB>2</SUB>Te<SUB>3</SUB> nanowires were potentiostatically electrodeposited using polycarbonate templates as scaffolds. The deposition conditions strongly influenced the deposit composition, crystal structures, and electrical properties of the nanowires. The preferential crystal orientation of the nanowires shifted from a {110} orientation at −20 mV to a {015} orientation at −100 mV. The temperature dependent <I>I–V</I> characteristics of bundle nanowires indicated that the nanowires were semiconductors with negative temperature coefficient of resistivity. The thermal activation energies were 0.20 eV for Bi<SUB>1.8</SUB>Sb<SUB>0.1</SUB>Te<SUB>3.1</SUB> and 0.49 eV for (Bi<SUB>0.3</SUB>Sb<SUB>0.7</SUB>)<SUB>2</SUB>Te<SUB>3</SUB> nanowires, respectively.</P>
Integrated aero-structural optimization design of pre-bend wind turbine blades
Xiaofeng Guo,Xiaoli Fu,Huichao Shang,Jin Chen 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.11
In the optimization design of a pre-bend wind turbine blade, there is a coupling relationship between blade aerodynamic shape and structural layup. The evaluation index of a wind turbine blade not only shows on conventional ones, such as Annual energy production (AEP), cost, and quality, but also includes the size of the loads on the hub or tower. Hence, the design of pre-bend wind turbine blades is a true multi-objective engineering task. To make the integrative optimization design of the pre-bend blade, new methods for the blade’s pre-bend profile design and structural analysis for the blade sections were presented, under dangerous working conditions, and considering the fundamental control characteristics of the wind turbine, an integrated aerodynamic-structural design technique for pre-bend blades was developed based on the Multi-objective particle swarm optimization algorithm (MOPSO). By using the optimization method, a three-dimensional Pareto-optimal set, which can satisfy different matching requirements from overall design of a wind turbine, was obtained. The most suitable solution was chosen from the Pareto-optimal set and compared with the original 1.5 MW blade. The results show that the optimized blade have better performance in every aspect, which verifies the feasibility of this new method for the design of pre-bend wind turbine blades.
Xiaofeng Jiang,De Chen,Guangyang Xiang,Yezeng Wang,Lei Zhang,Xuewei Yang,Liangqi Cao,Heping Peng,Ping Xue 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.6
MicroRNAs (miRNAs) are regulatory small non-coding RNAs that can regulate gene expression by binding to gene elements, such as the gene promotor 5UTR, mainly in the 3UTR of mRNA. One miRNA targets many mRNAs, which can be regulated by many miRNAs, leading to a complex metabolic network. In our study, we found that the expression level of miR-590-5p is higher in the human hepatocellular carcinoma cell line HepG2 than in the normal hepatocellular cell line L02. Downregulation of miR-590-5p inhibited proliferation and invasion of hepatocellular carcinoma cells (HCCs). We also showed that expression of TGF-beta RII, which has been regarded as a regulator of tumor proliferation, invasion, and migration in hepatocellular carcinoma, is regulated by miRNA-590-5p. In addition, miR-590-5p downregulated the expression of TGF- beta RII by targeting the 3UTR of mRNA. We also found that downregulation of miR-590-5p was associated with an elevation of TGF-beta RII and inhibition of proliferation and invasion in HepG2 cells. Furthermore, overex-pression of miR-590-5p was associated with upregulation of TGF-beta RII and could promote proliferation and invasion in L02 cells. In conclusion, we determined that TGF-beta RII is a novel target of miRNA-590-5p. Thus, the role of TGF-beta RII in regulating proliferation and invasion of human HCCs is controlled by miR-590-5p. In other words, miR-590-5p promotes proliferation and invasion in human HCCs by directly targeting TGF-beta RII.
Xiaofeng Lv,Shihong Cui,Xiaoan Zhang,Chenchen Ren 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.2
Objective: Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. Methods: PubMed, Embase, ClinicalTrials.gov, and Cochrane Library were queried to assess the therapeutic value of NACT versus PDS in EOC. Electronic databases were queried by using the keywords “ovarian cancer/neoplasms”, “primary debulking surgery”, and “neoadjuvant chemotherapy”. Results: The available trials were pooled, and hazard ratios (HRs), relative risk ratios (RRs) and associated 95% confidence intervals (95% CIs) were determined. Sixteen trials involving 57,450 participants with EOC (NACT, 9,475; PDS, 47,975) were evaluated. We found that NACT resulted in markedly decreased overall survival than PDS in patients with EOC (HR=1.30; 95% CI=1.13–1.49; heterogeneity: p<0.001, I2=82.7%). Furthermore, our results demonstrated that the NACT group displayed increased completeness of debulking removal (RR=1.69, 95% CI=1.32–2.17; heterogeneity: p<0.001, I2=81.9%), and reduced risk of postsurgical death (RR=0.18, 95% CI=0.06–0.51; heterogeneity: p=0.698, I2=0%) and major infection (RR=0.29, 95% CI=0.17–0.51; heterogeneity: p=0.777, I2=0%) compared with patients administered PDS. Conclusions: This meta-analysis indicated that NACT results in increased completeness of debulking removal, and reduced risk of postsurgical death and major infection compared with PDS, while PDS is associated with improved survival in comparison with NACT in EOC patients. Trial Registration: PROSPERO Identifier: CRD42019120625