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- 저자 : Xiaobo Ji (검색결과 5 건)
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Flash-aware Virtual Memory System for Consumer Electronics
Xiaobo Ji,Fan Zeng 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.8
In this paper, an efficient flash-aware virtual memory system called FVMS is proposed for consumer electronics equipped with flash memory as secondary storage media. It introduces: 1) a redesigned read-ahead algorithm to delay the execution of page replacement algorithm, 2) a flash-aware page replacement algorithm considering access frequency, recent access time, and asymmetric I/O operation costs to reduce the number of flash page write operations and prevent serious degradation of page hit ratio, and 3) an efficient garbage collection policy taking into consideration the number of valid pages within each block and the number of erase operations on each block in order to reduce the cleaning cost and improve the degree of wear leveling. Experimental results show that the proposed FVMS outperforms existing virtual memory systems for flash memory in terms of energy consumption and the degree of wear leveling.
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Java Implementation of a Cloud-based SIM Secure Element NFC Payment Protocol
Xiaobo Ji,Fan Zeng,Bangxian Ye 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12
A number of security protocols have been designed for mobile transactions using Near Field Communication technology in the last few years. However, the component architectures of these protocols are rarely implemented in Java for further evaluation. In this paper, we briefly discuss our previously proposed mobile transaction authentication protocol and extend our work by presenting its Java implementation. This implementation provides a detailed analysis based on a number of factors with respect to the security considerations of the protocol, particularly in its design stage. Thus, it provides a broad verification as well as step-by-step evaluation of the protocol specifications from its implementation point of view.
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TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
Ji, Guohua,Liang, Hongbin,Wang, Falin,Wang, Nan,Fu, Songbin,Cui, Xiaobo Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.7
TSPAN12, a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that TSPAN12 could be a novel molecular target for the treatment of OC.
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TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
Guohua Ji,Hongbin Liang,Falin Wang,Nan Wang,Songbin Fu,Xiaobo Cui 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.7
TSPAN12, a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that TSPAN12 could be a novel molecular target for the treatment of OC.
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Jingcui Yu,Songbin Fu,Peng Liu,Xiaobo Cui,Yu Sui,Guohua Ji,Rongwei Guan,Donglin Sun,Wei Ji,Fangli Liu,An Liu,Yuzhen Zhao,Yang Yu,Yan Jin,Jing Bai,Jingshu Geng,Yingwei Xue,Jiping Qi,Ki-Young Lee 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1
Previously, we identified 3 overlapping regions showing loss of heterozygosity (LOH, R_1-R_3 from 11 to 30 cM) on chromosome 17 in 45 primary gastric cancers (GCs). The data indicated the presence of tumor suppressor genes (TSGs) on chromosome 17 involved in GC. Among the putative TSGs in these regions, HIC1 (in SR_1) and TOB1 (in SR_3) remain to be examined in GC. By immunohistochemistry (IHC), methylation-specific PCR (MSP) and western blot, we evaluated the expression and regulation status for HIC1 and TOB1 protein in GC. We narrowed down the deletion intervals on chromosome 17 and defined five smaller LOH subregions, SR_1-SR_5 (0.54 to 3.42 cM), in GC. We found that HIC1 had downregulated expression in 86% (91/106) and was methylated in 87% (26/30) of primary GCs. Of the primary GCs showing downregulation of HIC1 protein, 75% (18/24) had methylated HIC1 gene. TOB1 was either absent or expressed at reduced levels in 75% (73/97) of the GC samples. In addition, a general reduction was found in total and the ratio of unphosphorylated to phosphorylated TOB1 protein levels in the differentiated GC cell lines. Further analysis revealed significant simultaneous downregulation of both HIC1 and TOB1 protein in GC tissue microarray samples (67%, 52/78) and in primary GCs (65%, 11/17). These results indicate that silencing of HIC1 and TOB1 expression is a common occurrence in GC and may contribute to the development and progression of the disease.
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