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Guo, Pi,Shen, Shun-Li,Zhang, Qin,Zeng, Fang-Fang,Zhang, Wang-Jian,Hu, Xiao-Min,Zhang, Ding-Mei,Peng, Bao-Gang,Hao, Yuan-Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Objectives: To evaluate the performance of clustering methods used in the prognostic assessment of categorical clinical data for hepatocellular carcinoma (HCC) patients in China, and establish a predictable prognostic nomogram for clinical decisions. Materials and Methods: A total of 332 newly diagnosed HCC patients treated with hepatic resection during 2006-2009 were enrolled. Patients were regularly followed up at outpatient clinics. Clustering methods including the Average linkage, k-modes, fuzzy k-modes, PAM, CLARA, protocluster, and ROCK were compared by Monte Carlo simulation, and the optimal method was applied to investigate the clustering pattern of the indices including platelet count, platelet/lymphocyte ratio (PLR) and serum aspartate aminotransferase activity/platelet count ratio index (APRI). Then the clustering variable, age group, tumor size, number of tumor and vascular invasion were studied in a multivariable Cox regression model. A prognostic nomogram was constructed for clinical decisions. Results: The ROCK was best in both the overlapping and non-overlapping cases performed to assess the prognostic value of platelet-based indices. Patients with categorical platelet-based indices significantly split across two clusters, and those with high values, had a high risk of HCC recurrence (hazard ratio [HR] 1.42, 95% CI 1.09-1.86; p<0.01). Tumor size, number of tumor and blood vessel invasion were also associated with high risk of HCC recurrence (all p< 0.01). The nomogram well predicted HCC patient survival at 3 and 5 years. Conclusions: A cluster of platelet-based indices combined with other clinical covariates could be used for prognosis evaluation in HCC.
Yuping Li,Li-Hua Yao,Guan-Jie Wu,Xiao-Fang Pi,Yan-Chun Gong,Ruo-Shong Ye,Chen-Xi Wang 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.6
Novel small-molecule polysaccharide fractions,named POP II and POP III, were purified from Portulacaoleracea L. with average Mw values of 9.25 and 8.03 kDa,respectively. Monosaccharide analysis revealed that POP IIwas composed of Rha, Ara, Man, Glc, and Gal with molarratios of 1: 1.42: 0.44: 0.88: 1.59. POP III was composedof Rha, Ara, Glc, and Gal with molar ratios of 1: 1.16:0.23: 0.59. The antioxidant activities of the fractions wereevaluated using cell-free and cell-mediated radical generatingsystems. POPII and POP III possessed strong antioxidantactivities in both systems. The 2 novel polysaccharidefractions extracted from P. oleracea L. can be developed asnatural antioxidants for treatment of free radical-relateddiseases.