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Xiao‐Juan Li,Guang-Ping DONG,Jian-Min FANG,Hong-Jian LIU,Wan-Lin GUO 한국곤충학회 2018 Entomological Research Vol.48 No.4
The pine sawyer Monochamus alternatus Hope (Coleoptera: Cerambycidae) is a serious pest of several Pinus species, and the ectoparasitoid larvae of Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae) is an important natural enemy of this pest. The transcriptome of M. alternatus larvae was sequenced using the Illumina platform and immunity‐related genes were specifically analyzed. De novo assembly resulted in the identification of 24 241 unigenes, with a mean length of 1122 bp, in unparasitized M. alternatus larvae and 23 807 unigenes, with a mean length of 1140 bp, for parasitized larvae. Removal of redundant unigenes resulted in 26 095 all‐unigenes, of which 16 959 (64.99%) showed clear homology with some of the known genes in the National Center for Biotechnology Information nr database. Parasitization had notable effects on the transcriptome profile of M. alternatus larvae. In all, 2702 genes were differentially expressed in M. alternatus larvae after parasitization, with 1491 (55.18%) upregulated and 1211 (44.82%) downregulated. Moreover, expression levels of immunity‐related genes in M. alternatus larvae were markedly altered in response to parasitization by D. helophoroides. In conclusion, the transcriptome profiling data, especially the discovered of immunity‐related genes, help illustrate the molecular mechanisms of parasitism between D. helophoroides and M. alternatus and provide new insights into developing immunity regulation‐mediated control methods of M. alternatus.
Xiao‐Juan Li,Guang-Ping DONG,Jian-Min FANG,Hong-Jian LIU,Wan-Lin GUO 한국곤충학회 2017 Entomological Research Vol.47 No.3
Monochamus alternatus is a destructive stem‐boring herbivore of Pinus massoniana, and the principal vector of pine wood nematode. To investigate the impacts of boring by M. alternatus larvae on the emission of volatile organic compounds (VOCs) from their host trees, the VOCs from uninfested and M. alternatus larvae infested P. massoniana trees were observed using a gas chromatograph–mass spectrometer. We detected 12, 9, 18 and 14 volatile organic compounds from infested xylem, infested phloem, uninfested xylem and uninfested phloem, respectively. In P. massoniana xylem, the boring of M. alternatus larvae induced cyclosativene, and inhibited 4‐carene, humulene, styrene, α‐phellandrene, β‐myrcene, β‐phellandrene and γ‐terpinene. The relative amounts of camphene, copacamphene, longicyclene, longifolene, tricyclene and α‐longipinene were significantly increased, and the relative amounts of α‐pinene and β‐pinene were significantly decreased by the boring behaviors of M. alternatus larvae. In P. massoniana phloem, the boring of M. alternatus larvae induced 2‐bornanone, copacamphene, longicyclene and α‐longipinene, and inhibited 2‐carene, 4‐carene, styrene, α‐phellandrene, β‐myrcene, β‐phellandrene, β‐pinene, γ‐terpinene and ο‐cymene. The relative amounts of camphene, caryophyllene and longifolene were significantly increased by the boring behaviors of M. alternatus larvae. The results indicate that the boring behaviors of M. alternatus larvae changed both the sorts and contents of the VOCs from P. massoniana trees.
Phthalocyanines as medicinal photosensitizers: Developments in the last five years
Li, Xingshu,Zheng, Bing-De,Peng, Xiao-Hui,Li, Song-Zi,Ying, Jia-Wen,Zhao, Yuanyuan,Huang, Jian-Dong,Yoon, Juyoung Elsevier 2019 Coordination Chemistry Reviews Vol.379 No.-
<P><B>Abstract</B></P> <P>Owing to their high extinction coefficients, long absorption wavelengths, and modification tunable photophysical and photochemical properties, phthalocyanines (Pcs) have been widely used as photosensitizers for photodynamic therapy (PDT). Advances made in the past five years on the development of Pcs as medicinal photosensitizers are reviewed and the main design considerations for medicinal applications of these substances are discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Recent progresses made in the development of phthalocyanines for photodynamic therapy are outlined. </LI> <LI> Representative water-soluble phthalocyanines are presented. </LI> <LI> Main targeting strategies are discussed. </LI> <LI> Future challenges are also presented. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Staged Improvement in Awareness of Disease for Elderly Cancer Patients in Southern China
Li, Xing,Dong, Min,Wen, Jing-Yun,Wei, Li,Ma, Xiao-Kun,Xing, Yan-Fang,Deng, Yun,Chen, Zhan-Hong,Chen, Jie,Ruan, Dan-Yun,Lin, Ze-Xiao,Wang, Tian-Tian,Wu, Dong-Hao,Liu, Xu,Hu, Hai-Tao,Lin, Jia-Yu,Li, Zhu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: In mainland China, awareness of disease of elderly cancer patients largely relies on the patients' families. We developed a staged procedure to improve their awareness of disease. Materials and Methods: Participants were 224 elderly cancer patients from 9 leading hospitals across Southern China. A questionnaire was given to the oncologists in charge of each patient to evaluate the interaction between family and patients, patient awareness of their disease and participation in medical decision-making. After first cycles of treatment, increased information of disease was given to patients with cooperation of the family. Then patient awareness of their disease and participation in medical decision-making was documented. Results: Among the 224 cancer elderly patients, 26 (11.6%) made decisions by themselves and 125 (55.8%) delegated their rights of decision-making to their family. Subordinate family members tended to play a passive role in decision-making significantly. Patients participating more in medical decision-making tended to know more about their disease. However, in contrast to the awareness of disease, patient awareness of violation of medical recommendations was reversely associated with their participation in medical decision-making. Improvement in awareness of diagnosis, stages and prognosis was achieved in about 20% elderly cancer patients. About 5% participated more actively in medical decision-making. Conclusions: Chinese elderly cancer patient awareness of disease and participation in medical decision-making is limited and relies on their family status. The staged procedure we developed to improve patient awareness of disease proved effective.
Li Xia Li,Qi Long Ling,Zu Liang Liu,Xiao Dong Xing,Xiao Qin Zhu,Xiao Meng 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.10
A series of polystyrene-supported 1-(propyl-3-sulfonate)-3-methyl-imidazolium hydrosulfate acidic ionic liquid (PS-[SO3H-PMIM][HSO4]) catalysts were prepared and tested for mononitration of simple aromatics compounds with nitric acid. It was found that the reactivity of the catalysts increased with increasing [SO3HPMIM][ HSO4] content. The para-selectivity was not only related to the [SO3H-PMIM][HSO4] content but also the substituent groups in aromatics. A reaction mechanism of nitration over this new catalyst was proposed. The catalytic activity of this catalyst decreased slightly after fifth runs in the synthesis of nitrotoluene.
Li-jun Liang,Chen-xi Hu,Yi-xuan Wen,Xiao-wei Geng,Ting Chen,Guo-qing Gu,Lei Wang,You-you Xia,Yong Liu,Jia-yan Fei,Jie Dong,Feng-hua Zhao,Yiliyar Ahongjiang,Kai-yuan Hui,Xiao-dong Jiang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Methods Lewis lung cancer cells were injected into C57BL/6 mice in the left hindlimb (primary tumor; irradiated) and in the right flank (secondary tumor; nonirradiated). When both tumors grew to the touchable size, mice were randomly divided into eight treatment groups. These groups received normal saline or three distinct doses of apatinib (50 mg/kg, 150 mg/kg, and 200 mg/kg) daily for 7 days, in combination with a single dose of 15 Gy radiotherapy or not to the primary tumor. The further tumor growth/regression of mice were followed and observed. Results For the single 15 Gy modality, tumor growth delay could only be observed at the primary tumor. When combining SABR and apatinib 200 mg/kg, significant retardation of both primary and secondary tumor growth could be observed, indicated an abscopal effect was induced. Mechanism analysis suggested that programmed death-ligand 1 expression increased with SABR was counteract by additional apatinib therapy. Furthermore, when apatinib was combined with SABR, the composition of immune cells could be changed. More importantly, this two-pronged approach evoked tumor antigen–specific immune responses and the mice were resistant to another tumor rechallenge, finally, long-term survival was improved. Conclusion Our results suggested that the tumor microenvironment could be managed with apatinib, which was effective in eliciting an abscopal effect induced by SABR.
Intermedins A and B; New Metabolites from Schisandra propinqua var. intermedia
Li, Hong-Mei,Lei, Chun,Luo, Yong-Ming,Li, Xiao-Nian,Li, Xiao-Lei,Pu, Jian-Xin,Zhou, San-Yun,Li, Rong-Tao,Sun, Han-Dong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
A new dibenzocyclooctadiene lignan, intermedin A (1), and a new natural bisabolane sesquiterpenoid, intermedin B (2), were isolated from the aerial parts of Schisandra propinqua var. intermedia. Their structures were elucidated on the basis of extensive spectroscopical analysis.
Li, Xiao-Dong,Park, Changbom,Sabiu, Cristiano G.,Park, Hyunbae,Weinberg, David H.,Schneider, Donald P.,Kim, Juhan,Hong, Sungwook E. American Astronomical Society 2016 The Astrophysical journal Vol.832 No.2
<P>We apply the methodology developed in Li et al. to BOSS DR12 galaxies and derive cosmological constraints from the redshift dependence of the Alcock-Paczynski (AP) effect. The apparent anisotropy in the distribution of observed galaxies arise from two main sources, the redshift-space distortion (RSD) effect due to the galaxy peculiar velocities, and the geometric distortion when incorrect cosmological models are assumed for transforming redshift to comoving distance, known as the AP effect. Anisotropies produced by the RSD effect are, although large, maintaining a nearly uniform magnitude over a large range of redshift, while the degree of anisotropies from the AP effect varies with redshift by a much larger magnitude. We split the DR12 galaxies into six redshift bins, measure the two-point correlation function in each bin, and assess the redshift evolution of anisotropies. We obtain constraints of Omega(m) = 0.290 +/- 0.053, w = - 1.07 +/- 0.15, which are comparable with the current constraints from other cosmological probes such as SNe Ia, cosmic microwave background, and baryon acoustic oscillation (BAO). Combining these cosmological probes with our method yield tight constraints of Omega(m) = 0.301 +/- 0.006, w = - 1.054 +/- 0.025. Our method is complementary to the other large-scale structure (LSS) probes like BAO and topology. We expect this technique will play an important role in deriving cosmological constraints from LSS surveys.</P>
Xiao-Qiang Li,Gui-Qiang Guo,Hong-Zhi Gao,Nan Song,Dong-Sheng Li 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
Al-Cu-Mg aluminum alloy sheet is widely used for aircraft skin. Multi-stage forming combined with Solution Heat Treatment (SHT) is necessary for some geometrically complex productions in aircraft skin components. However, the effects of pre-strain and natural ageing time on the formability of Al-Cu-Mg aluminum alloy sheet are not fully understood. In this study, the deformation responses of an Al-Cu-Mg aluminum alloy sheet, over a range of pre-strain levels (0% to 6%) and natural ageing time levels (0 h to 2 h) were investigated. A modified Hollomon constitutive model coupling with pre-strain and natural ageing time was proposed to characterize the deformation responses of the Al-Cu-Mg aluminum alloy sheet. The hemispherical dome tests were performed at natural ageing time levels ranging from 0.25 h to 1.5 h. Marciniak and Kuczynski (M-K) theory was used to obtain the forming limit prediction model which takes pre-strain and natural ageing time into account. The theoretical Forming Limit Curves (FLCs) were compared with the experimental results.